JWH-018

Ligand id: 9706

Name: JWH-018

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 22
Molecular weight 341.18
XLogP 7.14
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Synonyms
AM-678 | JWH 018 | JWH018
Comments
JWH-018 is a synthetic cannabinoid generated in the 1990s with limited selectivity between CB1 and CB2 receptors (original synthesis reported in: https://www.sciencedirect.com/science/article/pii/S0960894X01801554). In vivo, it displays the 'classical tetrad' activity of CB1 agonists, with analgesic, hypothermic, hypolocomotive and cataleptic properties [2]. In the UK, it was the structural basis for definition of a series of compounds classified as Controlled Drugs under the Misuse of Drugs Act 1971 (Amendment) Order 2016 (see: https://www.legislation.gov.uk/ukdsi/2016/9780111148716). It is the non-fluorinated analogue of AM2201.
Database Links
BindingDB Ligand 50353747
ChEMBL Ligand CHEMBL561013
GtoPdb PubChem SID 348353665
PubChem CID 10382701
Search Google for chemical match using the InChIKey JDNLPKCAXICMBW-UHFFFAOYSA-N
Search Google for chemicals with the same backbone JDNLPKCAXICMBW
Search UniChem for chemical match using the InChIKey JDNLPKCAXICMBW-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone JDNLPKCAXICMBW

Product suppliers

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Tocris
JWH 018
Cat. No. 1342