ChEMBL ligand: CHEMBL7550 (L-158809)
Angiotensin II type 1a (AT-1a) receptor in Bovine [ChEMBL: CHEMBL3374] [UniProtKB: P25104] Angiotensin II type 1a (AT-1a) receptor in Rabbit [ChEMBL: CHEMBL3948] [UniProtKB: P34976] There should be some charts here, you may need to enable JavaScript!
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Human [ChEMBL: CHEMBL4607] [GtoPdb: 35] [UniProtKB: P50052] AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1A angiotensin II receptor in Rat [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089, P25095] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1B angiotensin II receptor in Rat [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Angiotensin II type 1a (AT-1a) receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3374] [UniProtKB: P25104]
ChEMBL	Compound was tested for in vitro for AII receptor antagonistic activity in bovine adrenal cortex.	F	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1709-1714
Angiotensin II type 1a (AT-1a) receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3948] [UniProtKB: P34976]
ChEMBL	Inhibition of Angiotensin II receptor type 1 in rabbit aorta binding assay	B	9.1	pIC50	0.8	nM	IC50	Bioorg Med Chem Lett (1994) 4: 189-194
ChEMBL	In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.	F	9.27	pIC50	0.54	nM	IC50	J Med Chem (1993) 36: 4239-4249 [PMID:8277506]
ChEMBL	Displacement of [1251][Sar1,IIe8]AII from rabbit aorta Angiotensin II receptor, type 1	B	9.27	pIC50	0.54	nM	IC50	J Med Chem (1993) 36: 3738-3742 [PMID:8246245]
ChEMBL	In vitro antagonist activity against angiotensin II receptor type 1 in rabbit aorta using [125I]-Sar, Ile AII.	F	9.27	pIC50	0.54	nM	IC50	J Med Chem (1993) 36: 4230-4238 [PMID:8277505]
ChEMBL	In vitro binding affinity towards Angiotensin II type 1-AT1 receptor determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rabbit aorta membrane.	B	9.3	pIC50	0.5	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1693-1696
ChEMBL	Binding affinity evaluated by its ability to displace the specific binding ligand 125I-SAR1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (1994) 4: 207-212
ChEMBL	Inhibitory activity was evaluated against Angiotensin II receptor, type 1 in rabbit aorta	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (1996) 39: 625-656 [PMID:8576904]
ChEMBL	Inhibition of Angiotensin II receptor, type 1	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (1993) 36: 2051-2058 [PMID:8340909]
ChEMBL	Binding affinity to angiotensin AT1 receptor in rabbit aortic rings	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
ChEMBL	In vitro binding affinity for angiotensin II AT1 receptor in rabbit aorta	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (1994) 37: 4068-4072 [PMID:7990105]
ChEMBL	Displacement of the specific binding ligand [125I]Sar1,Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membrane.	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (1994) 4: 41-44
ChEMBL	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from Angiotensin II receptor, type 1 in rabbit aorta membranes	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (1994) 4: 17-22
ChEMBL	Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (1993) 36: 591-609 [PMID:8496939]
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4607] [GtoPdb: 35] [UniProtKB: P50052]
ChEMBL	Binding affinity to angiotensin AT2 receptor	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
AT2 receptor/Angiotensin II type 2 (AT-2) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL257] [GtoPdb: 35] [UniProtKB: P35351]
ChEMBL	In vitro binding affinity for angiotensin II AT2 receptor in rat midbrain	B	4.3	pIC50	50000	nM	IC50	J Med Chem (1994) 37: 4068-4072 [PMID:7990105]
ChEMBL	In vitro binding affinity towards Angiotensin II receptor, type 2 determined as its ability to displace 125I-Sarl,Ile8-AII from the receptor expressed in rat midbrain membrane.	B	4.7	pIC50	>20000	nM	IC50	Bioorg Med Chem Lett (1993) 3: 1693-1696
ChEMBL	In vitro antagonist activity against angiotensin II receptor type 2 in rat midbrain using [125I]-Sar,Ile AII.	F	5	pIC50	>10000	nM	IC50	J Med Chem (1993) 36: 4230-4238 [PMID:8277505]
ChEMBL	In vitro antagonist activity against angiotensin II type 2 (AT2) receptor in rat midbrain using [125I]- Sar, Ile AII.	F	5	pIC50	>10000	nM	IC50	J Med Chem (1993) 36: 4239-4249 [PMID:8277506]
ChEMBL	In vitro binding affinity determined by its ability to displace the specific binding ligand [125I]-Sar1, Ile8-AII from AT2 receptor in rat midbrain membranes	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (1994) 4: 17-22
ChEMBL	Displacement of [1251][Sar1,IIe8]AII from rat midbrain angiotensin II (AT2) receptor	B	5	pIC50	>10000	nM	IC50	J Med Chem (1993) 36: 3738-3742 [PMID:8246245]
ChEMBL	Inhibition of rat midbrain angiotensin II type 2 receptor	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem Lett (1994) 4: 189-194
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Partial agonist activity at human PPARgamma-LBD/Gal4 DNA binding domain by transactivation assay	B	4.7	pEC50	>20000	nM	EC50	J Med Chem (2011) 54: 4219-4233 [PMID:21557540]
AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095]
GtoPdb	-	-	9.18	pKd	0.66	nM	Kd	Mol Pharmacol (1992) 42: 1077-82 [PMID:1480133]
ChEMBL	Binding affinity against angiotensin II receptor from rat liver	B	9.35	pKi	0.45	nM	Ki	J Med Chem (1993) 36: 2676-2688 [PMID:8410980]
ChEMBL	Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2008) 51: 2137-2146 [PMID:18318468]
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL	Displacement of [125I]Tyr4-Sar1,Ile8-Angiotensin II from human Angiotensin 1 receptor after 60 mins by scintillation counting	B	8.57	pIC50	2.7	nM	IC50	J Med Chem (2011) 54: 4219-4233 [PMID:21557540]
ChEMBL	Antagonist activity at angiotensin 1 receptor	F	9.52	pIC50	0.3	nM	IC50	J Med Chem (2011) 54: 2529-2591 [PMID:21413808]
AT1 receptor in Rat [GtoPdb: 34] [UniProtKB: P29089, P25095]
GtoPdb	-	-	9.18	pKd	0.66	nM	Kd	Mol Pharmacol (1992) 42: 1077-82 [PMID:1480133]
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
GtoPdb	-	-	9.18	pKd	0.66	nM	Kd	Mol Pharmacol (1992) 42: 1077-82 [PMID:1480133]
ChEMBL	Binding affinity for rat angiotensin II receptor, type 1	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (2004) 47: 2574-2586 [PMID:15115399]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]