compound 1 [PMID: 18507370] [Ligand Id: 8673] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL487942
  • Endothelin-converting enzyme 2 in Human [ChEMBL: CHEMBL5890] [UniProtKB: P0DPD6]
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  • Endothelin-converting enzyme 2 in Human [GtoPdb: 1616] [UniProtKB: O60344]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Endothelin-converting enzyme 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5890] [UniProtKB: P0DPD6]
ChEMBL Reduction of recombinant ECE2 activity measured by McaBk2 fluorescent substrate hydrolysis B 5.33 pIC50 4630 nM IC50 J. Med. Chem. (2008) 51: 3378-3387 [PMID:18507370]
Endothelin-converting enzyme 2 in Human [GtoPdb: 1616] [UniProtKB: O60344]
GtoPdb - - 5.19 pIC50 6420 nM IC50 J. Med. Chem. (2008) 51: 3378-87 [PMID:18507370]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]