Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	811	3q27.1	ECE2	endothelin converting enzyme 2
Mouse	1	763	16 B1	Ece2	endothelin converting enzyme 2
Rat	-	754	11q23	Ece2	endothelin-converting enzyme 2

Database Links
Specialist databases
MEROPS	M13.003 (Hs)
Other databases
Alphafold	P0DPD6 (Hs), B2RQR8 (Mm)
BRENDA	3.4.24.71
CATH/Gene3D	3.40.390.10
ChEMBL Target	CHEMBL5890 (Hs)
Ensembl Gene	ENSG00000145194 (Hs), ENSMUSG00000022842 (Mm), ENSRNOG00000001715 (Rn)
Entrez Gene	9718 (Hs), 107522 (Mm), 408243 (Rn)
Human Protein Atlas	ENSG00000145194 (Hs)
KEGG Enzyme	3.4.24.71
KEGG Gene	hsa:9718 (Hs), mmu:107522 (Mm), rno:408243 (Rn)
OMIM	610145 (Hs)
Pharos	P0DPD6 (Hs)
RefSeq Nucleotide	NM_001037324 (Hs), NM_014693 (Hs), NM_001100121 (Hs), NM_001100120 (Hs), NM_032331 (Hs), NM_177941 (Mm), NM_177940 (Mm), NM_025462 (Mm), NM_001002815 (Rn)
RefSeq Protein	NP_001032401 (Hs), NP_115707 (Hs), NP_055508 (Hs), NP_001093591 (Hs), NP_001093590 (Hs), NP_808810 (Mm), NP_808809 (Mm), NP_079738 (Mm), NP_001002815 (Rn)
UniProtKB	P0DPD6 (Hs), B2RQR8 (Mm)
Wikipedia	ECE2 (Hs)

Enzyme Reaction
EC Number: 3.4.24.71

Endogenous substrates (Human)

endothelin-1 (EDN1, P05305), endothelin-2 (EDN2, P20800), endothelin-3 (EDN3, P14138)

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference S136492 Hs Inhibition 5.3 pIC50 1 ⤷ pIC50 5.3 (IC50 4.63x10-6 M) [1] compound 1 [PMID: 18507370] Hs Inhibition 5.2 pIC50 1 ⤷ pIC50 5.2 (IC50 6.42x10-6 M) [1]