midostaurin [Ligand Id: 5702] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL608533 (CGP 41251, CGP-41251, Midostaurin, Midostaurina, Midostaurine, NSC-656576, NVP-PKC412, Pkc-412, PKC 412, PKC-412, Rydapt) |
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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There should be some charts here, you may need to enable JavaScript!
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 26S protease regulatory subunit 6B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831205] [UniProtKB: P43686] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| 3-phosphoinositide dependent protein kinase 1/3-phosphoinositide dependent protein kinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2534] [GtoPdb: 1519] [UniProtKB: O15530] | ||||||||
| ChEMBL | Binding constant for full-length PDPK1 | B | 6.72 | pKd | 190 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PDPK1 kinase domain | B | 6.72 | pKd | 190 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PDPK1 | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| Actin-related protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6090] [UniProtKB: P61160] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Actin-related protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105857] [UniProtKB: P61158] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| activin A receptor type 1/Activin receptor type-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5903] [GtoPdb: 1785] [UniProtKB: Q04771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ACVR1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 1B/Activin receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5310] [GtoPdb: 1787] [UniProtKB: P36896] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ACVR1B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 2A/Activin receptor type-2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5616] [GtoPdb: 1791] [UniProtKB: P27037] | ||||||||
| ChEMBL | Binding constant for ACVR2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ACVR2A | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR2A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ACVR2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ACVR2B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVR2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AP2 associated kinase 1/Adaptor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3830] [GtoPdb: 1921] [UniProtKB: Q2M2I8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.38 | pKd | 413 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AAK1 kinase domain | B | 7.32 | pKd | 48 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AAK1 | B | 7.32 | pKd | 48 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AAK1 kinase domain | B | 7.32 | pKd | 48 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity of AAK1 (unknown origin) assessed as dissociation constant | B | 7.32 | pKd | 48 | nM | Kd | Eur J Med Chem (2023) 248: 115102-115102 [PMID:36640459] |
| ChEMBL | Inhibition of AAK1 (unknown origin) | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2022) 65: 893-921 [PMID:33539089] |
| Adenosine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3589] [GtoPdb: 1231] [UniProtKB: P55263] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Adenylate kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4938] [UniProtKB: P54819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 2/ADP/ATP translocase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3709670] [GtoPdb: 1063] [UniProtKB: P05141] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Mitochondrial adenine nucleotide translocator 3/ADP/ATP translocase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105854] [GtoPdb: 1064] [UniProtKB: P12236] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
| ChEMBL | Binding constant for ALK kinase domain | B | 6.57 | pKd | 270 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ALK | B | 6.57 | pKd | 270 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ALK kinase domain | B | 6.57 | pKd | 270 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated catalytic subunit alpha 1/AMP-activated protein kinase, alpha-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4045] [GtoPdb: 1541] [UniProtKB: Q13131] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.89 | pKd | 12843 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AMPK-alpha1 | B | 6.74 | pKd | 180 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AMPK-alpha1 kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated catalytic subunit alpha 2/AMP-activated protein kinase, alpha-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2116] [GtoPdb: 1542] [UniProtKB: P54646] | ||||||||
| ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 6.34 | pKd | 460 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AMPK-alpha2 | B | 6.34 | pKd | 460 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AMPK-alpha2 kinase domain | B | 6.34 | pKd | 460 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase AMP-activated non-catalytic subunit gamma 1/AMP-activated protein kinase, gamma-1 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2393] [GtoPdb: 1545] [UniProtKB: P54619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.93 | pKd | 1168 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase AMP-activated non-catalytic subunit gamma 2/AMP-activated protein kinase, gamma-2 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2453] [GtoPdb: 1546] [UniProtKB: Q9UGJ0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.04 | pKd | 9128 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ankyrin repeat and kinase domain containing 1/Ankyrin repeat and protein kinase domain-containing protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5547] [GtoPdb: 1932] [UniProtKB: Q8NFD2] | ||||||||
| ChEMBL | Binding constant for ANKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ANKK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ANKK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Aspartyl/asparaginyl beta-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4680030] [UniProtKB: Q12797] | ||||||||
| ChEMBL | Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with high 200 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis | B | 4.91 | pIC50 | 12400 | nM | IC50 | Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066] |
| ChEMBL | Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis | B | 5.03 | pIC50 | 9430 | nM | IC50 | Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066] |
| ChEMBL | Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using 1 uM hFX-CP as substrate mixture with 3 uM 2OG, 100 uM L-ascorbic acid and high 20 uM FAS incubated for 35 mins by MS analysis | B | 5.14 | pIC50 | 7280 | nM | IC50 | Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066] |
| ChEMBL | Inhibition of N-His6-tagged human AspH (315-755) expressed in Escherichia coli BL21 (DE3) using high 10 uM hFX-CP as substrate mixture with 10 uM 2OG, 100 uM L-ascorbic acid and 2 uM FAS incubated for 35 mins by MS analysis | B | 5.22 | pIC50 | 6020 | nM | IC50 | Bioorg Med Chem (2020) 28: 115675-115675 [PMID:33069066] |
| ABCG2/ATP-binding cassette sub-family G member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5393] [GtoPdb: 792] [UniProtKB: Q9UNQ0] | ||||||||
| ChEMBL | Inhibition of ABCG2 efflux pump in multi-drug resistance human HL-60 cells assessed as reversal of daunorubicin sensitivity | B | 5.35 | pIC50 | 4436 | nM | IC50 | Eur J Med Chem (2022) 239: 114542-114542 [PMID:35751979] |
| ATP-dependent RNA helicase DDX1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2010634] [UniProtKB: Q92499] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ATP-dependent RNA helicase DDX3X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5553] [UniProtKB: O00571] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BMP2 inducible kinase/BMP-2-inducible protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4522] [GtoPdb: 1941] [UniProtKB: Q9NSY1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.28 | pKd | 528 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BIKE kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BIKE | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BIKE kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type IA/Bone morphogenetic protein receptor type-1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5275] [GtoPdb: 1786] [UniProtKB: P36894] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BMPR1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BMPR1A | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR1A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type IB/Bone morphogenetic protein receptor type-1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5476] [GtoPdb: 1789] [UniProtKB: O00238] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to BMPR1B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR1B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| bone morphogenetic protein receptor type 2/Bone morphogenetic protein receptor type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5467] [GtoPdb: 1794] [UniProtKB: Q13873] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BMPR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BMPR2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMPR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Brain glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3856] [UniProtKB: P11216] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BCR activator of RhoGEF and GTPase/Breakpoint cluster region protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5146] [GtoPdb: 2755] [UniProtKB: P11274] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| BR serine/threonine kinase 1/BR serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5650] [GtoPdb: 1946] [UniProtKB: Q8TDC3] | ||||||||
| ChEMBL | Binding constant for BRSK1 kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BRSK1 | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRSK1 kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BR serine/threonine kinase 2/BR serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4574] [GtoPdb: 1947] [UniProtKB: Q8IWQ3] | ||||||||
| ChEMBL | Binding constant for full-length BRSK2 | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BRSK2 | B | 6.19 | pKd | 650 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRSK2 kinase domain | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Calcium-dependent protein kinase 1 in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908387] [UniProtKB: P62344] | ||||||||
| ChEMBL | Binding constant for PFCDPK1(P.falciparum) kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase I/CaM kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2493] [GtoPdb: 1952] [UniProtKB: Q14012] | ||||||||
| ChEMBL | Binding constant for full-length CAMK1 | B | 5.7 | pKd | 2000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK1 | B | 5.7 | pKd | 2000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK1 kinase domain | B | 5.7 | pKd | 2000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase ID/CaM kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5073] [GtoPdb: 1953] [UniProtKB: Q8IU85] | ||||||||
| ChEMBL | Binding constant for CAMK1D kinase domain | B | 6.17 | pKd | 670 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK1D | B | 6.17 | pKd | 670 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK1D kinase domain | B | 6.17 | pKd | 670 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase IG/CaM kinase I gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5258] [GtoPdb: 1954] [UniProtKB: Q96NX5] | ||||||||
| ChEMBL | Binding constant for CAMK1G kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for CAMK1G kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II alpha subunit/CaM kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4147] [GtoPdb: 1555] [UniProtKB: Q9UQM7] | ||||||||
| ChEMBL | Binding constant for CAMK2A kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK2A | B | 7.7 | pKd | 20 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2A kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II beta subunit/CaM kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4121] [GtoPdb: 1556] [UniProtKB: Q13554] | ||||||||
| ChEMBL | Binding constant for CAMK2B kinase domain | B | 6.68 | pKd | 210 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK2B | B | 6.68 | pKd | 210 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2B kinase domain | B | 6.68 | pKd | 210 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II delta subunit/CaM kinase II delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2801] [GtoPdb: 1558] [UniProtKB: Q13557] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.23 | pKd | 588 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK2D kinase domain | B | 7.44 | pKd | 36 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK2D | B | 7.44 | pKd | 36 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2D kinase domain | B | 7.44 | pKd | 36 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin-dependent protein kinase II gamma subunit/CaM kinase II gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3829] [GtoPdb: 1557] [UniProtKB: Q13555] | ||||||||
| ChEMBL | Binding affinity to CAMK1G | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.42 | pKd | 380 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK2G kinase domain | B | 6.85 | pKd | 140 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK2G | B | 6.85 | pKd | 140 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK2G kinase domain | B | 6.85 | pKd | 140 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase IV/CaM kinase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2494] [GtoPdb: 1955] [UniProtKB: Q16566] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase kinase 1/CaM-kinase kinase alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5256] [GtoPdb: 1956] [UniProtKB: Q8N5S9] | ||||||||
| ChEMBL | Binding constant for CAMKK1 kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMKK1 | B | 6.89 | pKd | 130 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMKK1 kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| calcium/calmodulin dependent protein kinase kinase 2/CaM-kinase kinase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5284] [GtoPdb: 1957] [UniProtKB: Q96RR4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.44 | pKd | 3616 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CAMKK2 kinase domain | B | 7.14 | pKd | 73 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CAMKK2 | B | 7.14 | pKd | 73 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CAMKK2 kinase domain | B | 7.14 | pKd | 73 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4101] [GtoPdb: 1476] [UniProtKB: P17612] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PKAC-alpha kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, catalytic, beta subunit/cAMP-dependent protein kinase beta-1 catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2918] [GtoPdb: 1477] [UniProtKB: P22694] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length PKAC-beta | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PKAC-beta | B | 6.62 | pKd | 240 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKAC-beta kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase, cAMP-dependent, catalytic, gamma subunit/cAMP-dependent protein kinase, gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2743] [GtoPdb: 1478] [UniProtKB: P22612] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase, cAMP-dependent, regulatory, type II, alpha subunit/cAMP-dependent protein kinase type II-alpha regulatory subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2221] [GtoPdb: 1474] [UniProtKB: P13861] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CSNK1A1L | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1A1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1D | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK1D | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1D kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1E | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK1E | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1E kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| casein kinase 1 gamma 1/Casein kinase I gamma 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2426] [GtoPdb: 1999] [UniProtKB: Q9HCP0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK1G1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 gamma 2/Casein kinase I gamma 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2543] [GtoPdb: 2000] [UniProtKB: P78368] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1G2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK1G2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] | ||||||||
| ChEMBL | Binding constant for CSNK2A1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for full-length CSNK2A1 | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK2A1 | B | 6.6 | pKd | 250 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK2A2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK2A2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK2A2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 alpha 1 like/Casein kinase I isoform alpha-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5520] [GtoPdb: 1996] [UniProtKB: Q8N752] | ||||||||
| ChEMBL | Binding constant for full-length CSNK1A1L | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for CSNK1A1L kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| casein kinase 1 gamma 3/Casein kinase I isoform gamma-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5084] [GtoPdb: 2001] [UniProtKB: Q9Y6M4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSNK1G3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSNK1G3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSNK1G3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Cell division control protein 2 homolog in Plasmodium falciparum 3D7 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908388] [UniProtKB: P61075] | ||||||||
| ChEMBL | Binding constant for PFPK5(P.falciparum) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 19/Cell division cycle 2-like protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6002] [GtoPdb: 1972] [UniProtKB: Q9BWU1] | ||||||||
| ChEMBL | Binding constant for CDK11 kinase domain | B | 5.14 | pKd | 7200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK11 | B | 5.14 | pKd | 7200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK11 kinase domain | B | 5.14 | pKd | 7200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 8/Cell division protein kinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5719] [GtoPdb: 1980] [UniProtKB: P49336] | ||||||||
| ChEMBL | Binding constant for CDK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK8 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Protein kinase G (PKG) 1/cGMP-dependent protein kinase 1 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4273] [GtoPdb: 1492] [UniProtKB: Q13976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKG1 kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKG1 | B | 6.6 | pKd | 250 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKG1 kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Protein kinase G (PKG) 2/cGMP-dependent protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2896] [GtoPdb: 1493] [UniProtKB: Q13237] | ||||||||
| ChEMBL | Binding constant for PRKG2 kinase domain | B | 7.13 | pKd | 74 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKG2 | B | 7.13 | pKd | 74 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKG2 kinase domain | B | 7.13 | pKd | 74 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| coenzyme Q8A/Chaperone activity of bc1 complex-like, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5550] [GtoPdb: 1927] [UniProtKB: Q8NI60] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ADCK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ADCK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| citron rho-interacting serine/threonine kinase/Citron Rho-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5579] [GtoPdb: 1509] [UniProtKB: O14578] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CIT | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CIT kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length JNK1 | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JNK1 | B | 5.36 | pKd | 4400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK1 kinase domain | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 9/c-Jun N-terminal kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4179] [GtoPdb: 1497] [UniProtKB: P45984] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length JNK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JNK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK2 kinase domain | B | 5.3 | pKd | 5000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 10/c-Jun N-terminal kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2637] [GtoPdb: 1498] [UniProtKB: P53779] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for JNK3 kinase domain | B | 5.44 | pKd | 3600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JNK3 | B | 5.44 | pKd | 3600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JNK3 kinase domain | B | 5.44 | pKd | 3600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 1/Cyclin-dependent kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL308] [GtoPdb: 1961] [UniProtKB: P06493] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 12/Cyclin-dependent kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559692] [GtoPdb: 1965] [UniProtKB: Q9NYV4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 13/Cyclin-dependent kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795192] [GtoPdb: 1966] [UniProtKB: Q14004] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CDC2L5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 3/Cyclin-dependent kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4442] [GtoPdb: 1975] [UniProtKB: Q00526] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 4/Cyclin-dependent kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL331] [GtoPdb: 1976] [UniProtKB: P11802] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CDK4-cyclinD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for CDK4-cyclinD3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4036] [GtoPdb: 1977] [UniProtKB: Q00535] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK5 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] | ||||||||
| ChEMBL | Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin dependent kinase 7/Cyclin-dependent kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3055] [GtoPdb: 1979] [UniProtKB: P50613] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK7 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK7 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 9/Cyclin-dependent kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3116] [GtoPdb: 1981] [UniProtKB: P50750] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CDK9 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDK9 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase like 1/Cyclin-dependent kinase-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5789] [GtoPdb: 1982] [UniProtKB: Q00532] | ||||||||
| ChEMBL | Binding constant for CDKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase like 2/Cyclin-dependent kinase-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5728] [GtoPdb: 1983] [UniProtKB: Q92772] | ||||||||
| ChEMBL | Binding affinity to CDKL2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin-dependent kinase like 3/Cyclin-dependent kinase-like 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163117] [GtoPdb: 1984] [UniProtKB: Q8IVW4] | ||||||||
| ChEMBL | Binding affinity to CDKL3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin-dependent kinase like 5/Cyclin-dependent kinase-like 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163112] [GtoPdb: 1986] [UniProtKB: O76039] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to CDKL5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDKL5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Cytochrome c1, heme protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105975] [UniProtKB: P08574] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dCTP pyrophosphatase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769292] [UniProtKB: Q9H773] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| death associated protein kinase 1/Death-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2558] [GtoPdb: 2002] [UniProtKB: P53355] | ||||||||
| ChEMBL | Binding constant for DAPK1 kinase domain | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DAPK1 | B | 5.33 | pKd | 4700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK1 kinase domain | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| death associated protein kinase 2/Death-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3123] [GtoPdb: 2003] [UniProtKB: Q9UIK4] | ||||||||
| ChEMBL | Binding constant for full-length DAPK2 | B | 6.05 | pKd | 890 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DAPK2 | B | 6.05 | pKd | 890 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK2 kinase domain | B | 6.05 | pKd | 890 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293] | ||||||||
| ChEMBL | Binding constant for full-length DLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for DAPK3 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DAPK3 | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DAPK3 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Delta(24)-sterol reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2331059] [UniProtKB: Q15392] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Deoxycytidine kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2447] [UniProtKB: P27707] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| discoidin domain receptor tyrosine kinase 2/Discoidin domain-containing receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5122] [GtoPdb: 1844] [UniProtKB: Q16832] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for DDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DDR2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| DnaJ homolog subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189122] [UniProtKB: P31689] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA replication licensing factor MCM4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105745] [UniProtKB: P33991] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1806] [GtoPdb: 2637] [UniProtKB: P11388] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| DNA topoisomerase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3396] [UniProtKB: Q02880] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| dual serine/threonine and tyrosine protein kinase/Dual serine/threonine and tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908386] [GtoPdb: 2008] [UniProtKB: Q6XUX3] | ||||||||
| ChEMBL | Binding constant for RIPK5 kinase domain | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 1/Dual specificity mitogen-activated protein kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3587] [GtoPdb: 2062] [UniProtKB: Q02750] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MEK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 2/Dual specificity mitogen-activated protein kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2964] [GtoPdb: 2063] [UniProtKB: P36507] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MEK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 3/Dual specificity mitogen-activated protein kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2109] [GtoPdb: 2064] [UniProtKB: P46734] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MEK3 | B | 5.28 | pKd | 5300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MEK3 | B | 5.28 | pKd | 5300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK3 kinase domain | B | 5.28 | pKd | 5300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 4/Dual specificity mitogen-activated protein kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2897] [GtoPdb: 2065] [UniProtKB: P45985] | ||||||||
| ChEMBL | Binding constant for MEK4 kinase domain | B | 5.32 | pKd | 4800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MEK4 | B | 5.32 | pKd | 4800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK4 kinase domain | B | 5.32 | pKd | 4800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 5/Dual specificity mitogen-activated protein kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4948] [GtoPdb: 2066] [UniProtKB: Q13163] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 6/Dual specificity mitogen-activated protein kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2171] [GtoPdb: 2067] [UniProtKB: P52564] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MEK6 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MEK6 kinase domain | B | 5.19 | pKd | 6500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase 7/Dual specificity mitogen-activated protein kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3530] [GtoPdb: 2068] [UniProtKB: O14733] | ||||||||
| ChEMBL | Binding constant for MKK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC like kinase 1/Dual specificity protein kinase CLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4224] [GtoPdb: 1990] [UniProtKB: P49759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CLK1 | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CLK1 | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK1 kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5.86 | pIC50 | 1367 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CLK2 kinase domain | B | 6.07 | pKd | 860 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CLK2 | B | 6.07 | pKd | 860 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK2 kinase domain | B | 6.07 | pKd | 860 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5.53 | pIC50 | 2979 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761] | ||||||||
| ChEMBL | Binding constant for full-length CLK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CLK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK3 kinase domain | B | 5.44 | pKd | 3600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| CDC like kinase 4/Dual specificity protein kinase CLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4203] [GtoPdb: 1993] [UniProtKB: Q9HAZ1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CLK4 kinase domain | B | 6.39 | pKd | 410 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CLK4 | B | 6.39 | pKd | 410 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CLK4 kinase domain | B | 6.39 | pKd | 410 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5.81 | pIC50 | 1555 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
| ChEMBL | Binding constant for TTK kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TTK | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TTK kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| testis associated actin remodelling kinase 1/Dual specificity testis-specific protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5604] [GtoPdb: 2239] [UniProtKB: Q15569] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TESK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TESK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TESK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to DYRK1A | B | 7 | pKd | 100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK1A kinase domain | B | 7 | pKd | 100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 6.05 | pIC50 | 886.5 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463] | ||||||||
| ChEMBL | Binding constant for full-length DYRK1B | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DYRK1B | B | 6.48 | pKd | 330 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK1B kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5.69 | pIC50 | 2035 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| dual specificity tyrosine phosphorylation regulated kinase 2/Dual-specificity tyrosine-phosphorylation regulated kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4376] [GtoPdb: 2011] [UniProtKB: Q92630] | ||||||||
| ChEMBL | Binding affinity to DYRK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DYRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| dual specificity tyrosine phosphorylation regulated kinase 3/Dual-specificity tyrosine-phosphorylation regulated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4575] [GtoPdb: 2012] [UniProtKB: O43781] | ||||||||
| ChEMBL | Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| dual specificity tyrosine phosphorylation regulated kinase 4/Dual specificity tyrosine-phosphorylation-regulated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075115] [GtoPdb: 2013] [UniProtKB: Q9NR20] | ||||||||
| ChEMBL | Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| Dynamin-like 120 kDa protein, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105705] [UniProtKB: O60313] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Electron transfer flavoprotein subunit beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105744] [UniProtKB: P38117] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Elongation factor Tu, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105970] [UniProtKB: P49411] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| EPH receptor A1/Ephrin type-A receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5810] [GtoPdb: 1821] [UniProtKB: P21709] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A2/Ephrin type-A receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2068] [GtoPdb: 1822] [UniProtKB: P29317] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A3/Ephrin type-A receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4954] [GtoPdb: 1823] [UniProtKB: P29320] | ||||||||
| ChEMBL | Binding constant for EPHA3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A4/Ephrin type-A receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3988] [GtoPdb: 1824] [UniProtKB: P54764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A5/Ephrin type-A receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3987] [GtoPdb: 1825] [UniProtKB: P54756] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A6/Ephrin type-A receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4526] [GtoPdb: 1826] [UniProtKB: Q9UF33] | ||||||||
| ChEMBL | Binding constant for EPHA6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA6 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A7/Ephrin type-A receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4602] [GtoPdb: 1827] [UniProtKB: Q15375] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHA7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA7 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor A8/Ephrin type-A receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4134] [GtoPdb: 1828] [UniProtKB: P29322] | ||||||||
| ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHA8 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHA8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B1/Ephrin type-B receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5072] [GtoPdb: 1830] [UniProtKB: P54762] | ||||||||
| ChEMBL | Binding constant for EPHB1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHB1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHB2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B3/Ephrin type-B receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4901] [GtoPdb: 1832] [UniProtKB: P54753] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHB3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B4/Ephrin type-B receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5147] [GtoPdb: 1833] [UniProtKB: P54760] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EPHB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EPHB4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| EPH receptor B6/Ephrin type-B receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5836] [GtoPdb: 1834] [UniProtKB: O15197] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to EPHB6 | B | 5.51 | pKd | 3100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EPHB6 kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 5.15 | pKd | 7000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(E746-A750del) kinase domain | B | 5.15 | pKd | 7000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5.28 | pKd | 5300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(G719S) kinase domain | B | 5.28 | pKd | 5300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EGFR G719S mutant | B | 5.28 | pKd | 5300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to EGFR L861Q mutant | B | 5.55 | pKd | 2800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 5.55 | pKd | 2800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L861Q) kinase domain | B | 5.55 | pKd | 2800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L747-T751del,Sins) kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(S752-I759del) kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-S752del, P753S) kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR G719C mutant | B | 5.82 | pKd | 1500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(G719C) kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to EGFR | B | 5.89 | pKd | 1300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR L858R mutant | B | 6.12 | pKd | 760 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 6.12 | pKd | 760 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L858R) kinase domain | B | 6.12 | pKd | 760 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 6.21 | pKd | 620 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for EGFR(L747-E749del, A750P) kinase domain | B | 6.21 | pKd | 620 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to EGFR L858R,T790M mutant | B | 7.59 | pKd | 26 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for EGFR(T790M) kinase domain | B | 8.01 | pKd | 9.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for EGFR(L858R,T790M) kinase domain | B | 8.06 | pKd | 8.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of EGFR (unknown origin) | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2022) 243: 114742-114742 [PMID:36155354] |
| discoidin domain receptor tyrosine kinase 1/Epithelial discoidin domain-containing receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5319] [GtoPdb: 1843] [UniProtKB: Q08345] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for DDR1 kinase domain | B | 5.14 | pKd | 7200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DDR1 | B | 5.14 | pKd | 7200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DDR1 kinase domain | B | 5.14 | pKd | 7200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| eukaryotic translation initiation factor 2 alpha kinase 1/Eukaryotic translation initiation factor 2-alpha kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6029] [GtoPdb: 2015] [UniProtKB: Q9BQI3] | ||||||||
| ChEMBL | Binding constant for EIF2AK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.69 | pKd | 2047 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| eukaryotic translation initiation factor 2 alpha kinase 4/Eukaryotic translation initiation factor 2-alpha kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5358] [GtoPdb: 2018] [UniProtKB: Q9P2K8] | ||||||||
| ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 7.41 | pKd | 39 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to GCN2 Kin.Dom.2, S808G mutant | B | 7.41 | pKd | 39 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GCN2(Kin.Dom.2,S808G) kinase domain | B | 7.41 | pKd | 39 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Eukaryotic translation initiation factor 5B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105852] [UniProtKB: O60841] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Exosome RNA helicase MTR4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105889] [UniProtKB: P42285] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ferrochelatase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879831] [UniProtKB: P22830] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| fibroblast growth factor receptor 1/Fibroblast growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3650] [GtoPdb: 1808] [UniProtKB: P11362] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FGFR1 kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGFR1 | B | 5.8 | pKd | 1600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR1 kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 2/Fibroblast growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4142] [GtoPdb: 1809] [UniProtKB: P21802] | ||||||||
| ChEMBL | Binding constant for FGFR2 kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGFR2 | B | 5.62 | pKd | 2400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR2 kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 3/Fibroblast growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2742] [GtoPdb: 1810] [UniProtKB: P22607] | ||||||||
| ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGFR3 G697C mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR3(G697C) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for FGFR3 kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGFR3 | B | 5.77 | pKd | 1700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR3 kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fibroblast growth factor receptor 4/Fibroblast growth factor receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3973] [GtoPdb: 1811] [UniProtKB: P22455] | ||||||||
| ChEMBL | Binding constant for FGFR4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGFR4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGFR4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein tyrosine kinase 2/Focal adhesion kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2695] [GtoPdb: 2180] [UniProtKB: Q05397] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PTK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FAK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| General transcription and DNA repair factor IIH helicase subunit XPD in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105743] [UniProtKB: P18074] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Glycine--tRNA ligase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105815] [UniProtKB: P41250] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| glycogen synthase kinase 3 alpha/Glycogen synthase kinase-3 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2850] [GtoPdb: 2029] [UniProtKB: P49840] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length GSK3A | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to GSK3A | B | 5.6 | pKd | 2500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GSK3A kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length GSK3B | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to GSK3B | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GSK3B kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis | B | 5.33 | pIC50 | 4636 | nM | IC50 | J Med Chem (2023) 66: 4106-4130 [PMID:36876904] |
| beta adrenergic receptor kinase 1/G-protein coupled receptor kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4079] [GtoPdb: 1466] [UniProtKB: P25098] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| G protein-coupled receptor kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5861] [GtoPdb: 1468] [UniProtKB: P32298] | ||||||||
| ChEMBL | Binding affinity to GRK4 | B | 6.96 | pKd | 110 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK4 kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075133] [GtoPdb: 1471] [UniProtKB: Q8WTQ7] | ||||||||
| ChEMBL | Binding affinity to GRK7 | B | 7.32 | pKd | 48 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK7 kinase domain | B | 7.32 | pKd | 48 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| GTP-binding nuclear protein Ran in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1741190] [UniProtKB: P62826] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Guanine nucleotide-binding protein G(i) subunit alpha-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105887] [UniProtKB: P04899] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Haem oxygenase 2/Heme oxygenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2546] [GtoPdb: 1442] [UniProtKB: P30519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| MET proto-oncogene, receptor tyrosine kinase/Hepatocyte growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3717] [GtoPdb: 1815] [UniProtKB: P08581] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MET M1250T mutant | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MET(M1250T) kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for MET kinase domain | B | 6.16 | pKd | 690 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MET | B | 6.16 | pKd | 690 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MET kinase domain | B | 6.16 | pKd | 690 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MET(Y1235D) kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MET Y1235D mutant | B | 6.25 | pKd | 560 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| homeodomain interacting protein kinase 1/Homeodomain-interacting protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5427] [GtoPdb: 2033] [UniProtKB: Q86Z02] | ||||||||
| ChEMBL | Binding affinity to HIPK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 2/Homeodomain-interacting protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4576] [GtoPdb: 2034] [UniProtKB: Q9H2X6] | ||||||||
| ChEMBL | Binding affinity to HIPK2 | B | 5.51 | pKd | 3100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK2 kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422] | ||||||||
| ChEMBL | Binding affinity to HIPK3 | B | 5.64 | pKd | 2300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK3 kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| homeodomain interacting protein kinase 4/Homeodomain-interacting protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075167] [GtoPdb: 2036] [UniProtKB: Q8NE63] | ||||||||
| ChEMBL | Binding affinity to HIPK4 | B | 6.02 | pKd | 950 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HIPK4 kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| hormonally up-regulated Neu-associated kinase/Hormonally up-regulated neu tumor-associated kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795165] [GtoPdb: 2037] [UniProtKB: P57058] | ||||||||
| ChEMBL | Binding affinity to HUNK | B | 6.62 | pKd | 240 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HUNK kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| component of inhibitor of nuclear factor kappa B kinase complex/Inhibitor of nuclear factor kappa B kinase alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3476] [GtoPdb: 1989] [UniProtKB: O15111] | ||||||||
| ChEMBL | Binding affinity to IKK-alpha | B | 5.42 | pKd | 3800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-alpha kinase domain | B | 5.42 | pKd | 3800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
| ChEMBL | Binding affinity to IKK-beta | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-beta kinase domain | B | 5.2 | pKd | 6300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| inhibitor of nuclear factor kappa B kinase subunit epsilon/Inhibitor of nuclear factor kappa B kinase epsilon subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3529] [GtoPdb: 2040] [UniProtKB: Q14164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.35 | pKd | 443 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length IKK-epsilon | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to IKK-epsilon | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IKK-epsilon kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IGF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to IGF1R | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IGF1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for INSR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to INSR | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for INSR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Insulin receptor-related receptor/Insulin receptor-related protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5483] [GtoPdb: 1802] [UniProtKB: P14616] | ||||||||
| ChEMBL | Binding constant for INSRR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to INSRR | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for INSRR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| eukaryotic translation initiation factor 2 alpha kinase 2/Interferon-induced, double-stranded RNA-activated protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5785] [GtoPdb: 2016] [UniProtKB: P19525] | ||||||||
| ChEMBL | Binding constant for PRKR kinase domain | B | 5.16 | pKd | 6900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKR | B | 5.16 | pKd | 6900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKR kinase domain | B | 5.16 | pKd | 6900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 1/Interleukin-1 receptor-associated kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3357] [GtoPdb: 2042] [UniProtKB: P51617] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to IRAK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IRAK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 3/Interleukin-1 receptor-associated kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5081] [GtoPdb: 2044] [UniProtKB: Q9Y616] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.42 | pKd | 3759 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IRAK3 kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to IRAK3 | B | 6.74 | pKd | 180 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for IRAK3 kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| interleukin 1 receptor associated kinase 4/Interleukin-1 receptor-associated kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3778] [GtoPdb: 2045] [UniProtKB: Q9NWZ3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for IRAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| leucine rich repeat kinase 2/Leucine-rich repeat serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075104] [GtoPdb: 2059] [UniProtKB: Q5S007] | ||||||||
| ChEMBL | Binding constant for LRRK2 kinase domain | B | 6.24 | pKd | 570 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for LRRK2(G2019S) kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| leukocyte receptor tyrosine kinase/Leukocyte tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5627] [GtoPdb: 1838] [UniProtKB: P29376] | ||||||||
| ChEMBL | Binding constant for LTK kinase domain | B | 5.52 | pKd | 3000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LTK | B | 5.52 | pKd | 3000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LTK kinase domain | B | 5.52 | pKd | 3000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LIM domain kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3836] [GtoPdb: 2054] [UniProtKB: P53667] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LIMK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LIMK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LIMK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LIM domain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5932] [GtoPdb: 2055] [UniProtKB: P53671] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LIMK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LIMK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LIMK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Liver glycogen phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2568] [UniProtKB: P06737] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| colony stimulating factor 1 receptor/Macrophage colony stimulating factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1844] [GtoPdb: 1806] [UniProtKB: P07333] | ||||||||
| ChEMBL | Binding constant for CSF1R kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSF1R | B | 6.48 | pKd | 330 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSF1R kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay | B | 2.15 | pIC50 | 2.15 | - | logIC50 | Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689] |
| ChEMBL | Inhibition of human FMS expressed in growth factor dependent mouse FDC-P1 cells assessed as inhibition of FMS-mediated cell proliferation in presence human CSF1 after 48 hrs by resazurin dye reduction assay | B | 6.85 | pIC50 | 142 | nM | IC50 | Bioorg Med Chem (2010) 18: 1789-1797 [PMID:20156689] |
| macrophage stimulating 1 receptor/Macrophage-stimulating protein receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2689] [GtoPdb: 1816] [UniProtKB: Q04912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MST1R | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST1R kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK activated protein kinase 2/MAP kinase-activated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2208] [GtoPdb: 2094] [UniProtKB: P49137] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAPKAPK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAPKAPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK activated protein kinase 5/MAP kinase-activated protein kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3094] [GtoPdb: 2096] [UniProtKB: Q8IW41] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAPKAPK5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAPKAPK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length ERK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length ERK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK interacting serine/threonine kinase 1/MAP kinase-interacting serine/threonine-protein kinase MNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4718] [GtoPdb: 2104] [UniProtKB: Q9BUB5] | ||||||||
| ChEMBL | Binding constant for full-length MKNK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MKNK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MKNK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length p38-alpha | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to p38-alpha | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-alpha kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length p38-beta | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to p38-beta | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-beta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| ChEMBL | Binding affinity to p38-delta | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-delta kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Binding constant for full-length p38-gamma | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to p38-gamma | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for p38-gamma kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MAPK interacting serine/threonine kinase 2/MAP kinase signal-integrating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4204] [GtoPdb: 2105] [UniProtKB: Q9HBH9] | ||||||||
| ChEMBL | Binding constant for MKNK2 kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MKNK2 | B | 6.02 | pKd | 950 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MKNK2 kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 2/MAP/microtubule affinity-regulating kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3831] [GtoPdb: 2098] [UniProtKB: Q7KZI7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.12 | pKd | 759 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MARK2 kinase domain | B | 7 | pKd | 100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MARK2 | B | 7 | pKd | 100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK2 kinase domain | B | 7 | pKd | 100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 4/MAP/microtubule affinity-regulating kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5754] [GtoPdb: 2100] [UniProtKB: Q96L34] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MARK4 kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MARK4 | B | 6.43 | pKd | 370 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK4 kinase domain | B | 6.43 | pKd | 370 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| maternal embryonic leucine zipper kinase/Maternal embryonic leucine zipper kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4578] [GtoPdb: 2102] [UniProtKB: Q14680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MELK | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MELK | B | 6.55 | pKd | 280 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MELK kinase domain | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Microtubule associated serine/threonine kinase 1/Microtubule-associated serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163128] [GtoPdb: 1510] [UniProtKB: Q9Y2H9] | ||||||||
| ChEMBL | Binding affinity to MAST1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAST1 kinase domain | B | 6.72 | pKd | 190 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Midasin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105779] [UniProtKB: Q9NU22] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| misshapen like kinase 1/Misshapen-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5518] [GtoPdb: 2103] [UniProtKB: Q8N4C8] | ||||||||
| ChEMBL | Binding affinity to MINK | B | 6.77 | pKd | 170 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MINK kinase domain | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 15/Mitogen-activated protein kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5198] [GtoPdb: 2090] [UniProtKB: Q8TD08] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ERK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK8 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK8 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 4/Mitogen-activated protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5759] [GtoPdb: 2091] [UniProtKB: P31152] | ||||||||
| ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] | ||||||||
| ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase 7/Mitogen-activated protein kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5332] [GtoPdb: 2093] [UniProtKB: Q13164] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ERK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERK5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 10/Mitogen-activated protein kinase kinase kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2873] [GtoPdb: 2070] [UniProtKB: Q02779] | ||||||||
| ChEMBL | Binding affinity to MLK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK2 kinase domain | B | 6.1 | pKd | 790 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MLK2 kinase domain | B | 6.1 | pKd | 790 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 11/Mitogen-activated protein kinase kinase kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2708] [GtoPdb: 2071] [UniProtKB: Q16584] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.1 | pKd | 799 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MLK3 | B | 6.1 | pKd | 790 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK3 kinase domain | B | 7.77 | pKd | 17 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MLK3 kinase domain | B | 7.77 | pKd | 17 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human MLK3 | B | 7.77 | pKd | 17 | nM | Kd | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
| mitogen-activated protein kinase kinase kinase 12/Mitogen-activated protein kinase kinase kinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908389] [GtoPdb: 2072] [UniProtKB: Q12852] | ||||||||
| ChEMBL | Binding constant for DLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 13/Mitogen-activated protein kinase kinase kinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163124] [GtoPdb: 2073] [UniProtKB: O43283] | ||||||||
| ChEMBL | Binding affinity to LZK | B | 5.55 | pKd | 2800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LZK kinase domain | B | 5.55 | pKd | 2800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 15/Mitogen-activated protein kinase kinase kinase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163127] [GtoPdb: 2075] [UniProtKB: Q6ZN16] | ||||||||
| ChEMBL | Binding affinity to MAP3K15 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K15 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5914] [GtoPdb: 2077] [UniProtKB: Q9Y2U5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K2 | B | 6.85 | pKd | 140 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K2 kinase domain | B | 6.85 | pKd | 140 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5970] [GtoPdb: 2078] [UniProtKB: Q99759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP3K3 | B | 6.68 | pKd | 210 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K3 kinase domain | B | 6.68 | pKd | 210 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4853] [GtoPdb: 2079] [UniProtKB: Q9Y6R4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAP3K4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP3K4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5285] [GtoPdb: 2080] [UniProtKB: Q99683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP3K5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ASK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ASK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 6/Mitogen-activated protein kinase kinase kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163123] [GtoPdb: 2081] [UniProtKB: O95382] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ASK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ASK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 7/Mitogen-activated protein kinase kinase kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5776] [GtoPdb: 2082] [UniProtKB: O43318] | ||||||||
| ChEMBL | Binding affinity to TAK1 | B | 6.89 | pKd | 130 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAK1 kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 9/Mitogen-activated protein kinase kinase kinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2872] [GtoPdb: 2084] [UniProtKB: P80192] | ||||||||
| ChEMBL | Binding constant for MLK1 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MLK1 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MLK1 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5749] [GtoPdb: 2085] [UniProtKB: Q92918] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K1 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to HPK1 | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HPK1 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 2/Mitogen-activated protein kinase kinase kinase kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5330] [GtoPdb: 2086] [UniProtKB: Q12851] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MAP4K2 | B | 5.6 | pKd | 2500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K2 kinase domain | B | 5.6 | pKd | 2500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 3/Mitogen-activated protein kinase kinase kinase kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5432] [GtoPdb: 2087] [UniProtKB: Q8IVH8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K3 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAP4K3 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K3 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K4 kinase domain | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAP4K4 | B | 6.19 | pKd | 650 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K4 kinase domain | B | 6.19 | pKd | 650 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase kinase 5/Mitogen-activated protein kinase kinase kinase kinase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4852] [GtoPdb: 2089] [UniProtKB: Q9Y4K4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MAP4K5 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MAP4K5 | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAP4K5 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ZAK sterile alpha motif and leucine zipper containing kinase AZK/Mixed lineage kinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3886] [GtoPdb: 2289] [UniProtKB: Q9NYL2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ZAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ZAK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ZAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Multifunctional protein ADE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5922] [UniProtKB: P22234] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| muscle associated receptor tyrosine kinase/Muscle, skeletal receptor tyrosine protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5684] [GtoPdb: 1847] [UniProtKB: O15146] | ||||||||
| ChEMBL | Binding constant for MUSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MUSK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MUSK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Myosin-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105888] [UniProtKB: Q7Z406] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| myosin IIIA/Myosin IIIA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5546] [GtoPdb: 2112] [UniProtKB: Q8NEV4] | ||||||||
| ChEMBL | Binding constant for MYO3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MYO3A | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYO3A kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin IIIB/Myosin-IIIB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5654] [GtoPdb: 2113] [UniProtKB: Q8WXR4] | ||||||||
| ChEMBL | Binding constant for MYO3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MYO3B | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYO3B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase 3/Myosin light chain kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4627] [GtoPdb: 2110] [UniProtKB: Q32MK0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MLCK kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2777] [GtoPdb: 1553] [UniProtKB: Q9H1R3] | ||||||||
| ChEMBL | Binding constant for MYLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MYLK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| myosin light chain kinase family member 4/Myosin light chain kinase family member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5426] [GtoPdb: 2111] [UniProtKB: Q86YV6] | ||||||||
| ChEMBL | Binding constant for SgK085 kinase domain | B | 6.19 | pKd | 640 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SgK085 | B | 6.19 | pKd | 640 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK4 kinase domain | B | 6.19 | pKd | 640 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Myosin light chain kinase, smooth muscle in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3062] [UniProtKB: P11799] | ||||||||
| ChEMBL | Binding constant for MLCK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| myosin light chain kinase/Myosin light chain kinase, smooth muscle in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2428] [GtoPdb: 1552] [UniProtKB: Q15746] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to MLCK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MYLK kinase domain | B | 5.7 | pKd | 2000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MYLK kinase domain | B | 5.7 | pKd | 2000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MYLK | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| DM1 protein kinase/Myotonin-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5320] [GtoPdb: 1505] [UniProtKB: Q09013] | ||||||||
| ChEMBL | Binding constant for DMPK kinase domain | B | 5.42 | pKd | 3800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DMPK | B | 5.42 | pKd | 3800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DMPK kinase domain | B | 5.42 | pKd | 3800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105781] [UniProtKB: Q9P0J0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| neurotrophic receptor tyrosine kinase 1/Nerve growth factor receptor Trk-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2815] [GtoPdb: 1817] [UniProtKB: P04629] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TRKA kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TRKA | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKA kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| neurotrophic receptor tyrosine kinase 2/Neurotrophic tyrosine kinase receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4898] [GtoPdb: 1818] [UniProtKB: Q16620] | ||||||||
| ChEMBL | Binding constant for TRKB kinase domain | B | 6.51 | pKd | 310 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TRKB | B | 6.51 | pKd | 310 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKB kinase domain | B | 6.51 | pKd | 310 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase non receptor 1/Non-receptor tyrosine-protein kinase TNK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5334] [GtoPdb: 2245] [UniProtKB: Q13470] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.06 | pKd | 863 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length TNK1 | B | 7.08 | pKd | 83 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TNK1 | B | 7.08 | pKd | 83 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNK1 kinase domain | B | 7.08 | pKd | 83 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| neurotrophic receptor tyrosine kinase 3/NT-3 growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5608] [GtoPdb: 1819] [UniProtKB: Q16288] | ||||||||
| ChEMBL | Binding constant for TRKC kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TRKC | B | 5.77 | pKd | 1700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TRKC kinase domain | B | 5.77 | pKd | 1700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NUAK family kinase 1/NUAK family SNF1-like kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5784] [GtoPdb: 2129] [UniProtKB: O60285] | ||||||||
| ChEMBL | Binding constant for ARK5 kinase domain | B | 7.39 | pKd | 41 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ARK5 | B | 7.39 | pKd | 41 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ARK5 kinase domain | B | 7.39 | pKd | 41 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NUAK family, SNF1-like kinase, 2/NUAK family SNF1-like kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5698] [GtoPdb: 2130] [UniProtKB: Q9H093] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SNARK kinase domain | B | 7.2 | pKd | 63 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SNARK | B | 7.2 | pKd | 63 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SNARK kinase domain | B | 7.2 | pKd | 63 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Obg-like ATPase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105704] [UniProtKB: Q9NTK5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| PAS domain containing serine/threonine kinase/PAS domain-containing serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6054] [GtoPdb: 2139] [UniProtKB: Q96RG2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| calcium/calmodulin dependent serine protein kinase/Peripheral plasma membrane protein CASK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908381] [GtoPdb: 1959] [UniProtKB: O14936] | ||||||||
| ChEMBL | Binding constant for CASK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Peroxisomal acyl-coenzyme A oxidase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105817] [UniProtKB: O15254] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Inhibition of ABCB1 in multi-drug resistance human HL-60 cells assessed as increase in daunorubicin accumulation | B | 7.17 | pIC50 | 68 | nM | IC50 | Eur J Med Chem (2022) 239: 114542-114542 [PMID:35751979] |
| Phenylalanine--tRNA ligase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105969] [UniProtKB: Q9NSD9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Phosphatidylethanolamine-binding protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105856] [UniProtKB: P30086] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing beta polypeptide in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5554] [GtoPdb: 2151] [UniProtKB: O00750] | ||||||||
| ChEMBL | Binding constant for PIK3C2B kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3C2B | B | 5.85 | pKd | 1400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma/Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163120] [GtoPdb: 2288] [UniProtKB: O75747] | ||||||||
| ChEMBL | Binding affinity to PIK3C2G | B | 6.24 | pKd | 570 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3C2G kinase domain | B | 6.24 | pKd | 570 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4-phosphate 5-kinase type 1 alpha/Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5969] [GtoPdb: 2164] [UniProtKB: Q99755] | ||||||||
| ChEMBL | Binding constant for full-length PIP5K1A | B | 6.51 | pKd | 310 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIP5K1A | B | 6.51 | pKd | 310 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIP5K1A kinase domain | B | 6.51 | pKd | 310 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4-phosphate 5-kinase type 1 gamma/Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908383] [GtoPdb: 2165] [UniProtKB: O60331] | ||||||||
| ChEMBL | Binding constant for PIP5K1C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 beta/Phosphatidylinositol-5-phosphate 4-kinase type-2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5667] [GtoPdb: 2162] [UniProtKB: P78356] | ||||||||
| ChEMBL | Binding constant for full-length PIP5K2B | B | 6.57 | pKd | 270 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIP5K2B | B | 6.57 | pKd | 270 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIP5K2B kinase domain | B | 6.57 | pKd | 270 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-5-phosphate 4-kinase type 2 gamma/Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1770034] [GtoPdb: 2163] [UniProtKB: Q8TBX8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PIP5K2C kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Phosphofructokinase platelet type in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2972] [UniProtKB: Q01813] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| phosphorylase kinase catalytic subunit gamma 1/Phosphorylase kinase gamma subunit 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4004] [GtoPdb: 2145] [UniProtKB: Q16816] | ||||||||
| ChEMBL | Binding constant for full-length PHKG1 | B | 6.05 | pKd | 900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PHKG1 kinase domain | B | 6.05 | pKd | 900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PHKG1 | B | 6.72 | pKd | 190 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| phosphorylase kinase catalytic subunit gamma 2/Phosphorylase kinase gamma subunit 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2349] [GtoPdb: 2147] [UniProtKB: P15735] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PHKG2 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PHKG2 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PHKG2 | B | 6.05 | pKd | 900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] | ||||||||
| ChEMBL | Binding constant for PIK3CA(Q546K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PIK3CA(M1043I) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIK3CA | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA C420R mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E542K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E545A mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA E545K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA H1047Y mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA M1043I mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to PIK3CA Q546K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(C420R) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E542K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E545A) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(E545K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(H1047Y) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for PIK3CA(I800L) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PIK3CA H1047L mutant | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CA(H1047L) kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] | ||||||||
| ChEMBL | Binding affinity to PIK3CB | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] | ||||||||
| ChEMBL | Binding affinity to PIK3CD | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CD kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] | ||||||||
| ChEMBL | Binding affinity to PIK3CG | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK3CG kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| phosphatidylinositol 4-kinase beta/PI4-kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3268] [GtoPdb: 2149] [UniProtKB: Q9UBF8] | ||||||||
| ChEMBL | Binding affinity to PIK4CB | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIK4CB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 11B/PITSLRE serine/threonine-protein kinase CDC2L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5808] [GtoPdb: 1964] [UniProtKB: P21127] | ||||||||
| ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDC2L1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDC2L1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 11A/PITSLRE serine/threonine-protein kinase CDC2L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5416] [GtoPdb: 1963] [UniProtKB: Q9UQ88] | ||||||||
| ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CDC2L2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CDC2L2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2007] [GtoPdb: 1803] [UniProtKB: P16234] | ||||||||
| ChEMBL | Binding constant for PDGFRA kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PDGFRA kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PDGFRA | B | 6.74 | pKd | 180 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PDGFRB | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PDGFRB kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PDGFRB kinase domain | B | 6.96 | pKd | 110 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Probable ATP-dependent RNA helicase DDX6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105783] [UniProtKB: P26196] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Protein delta homolog 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5671] [UniProtKB: P80370] | ||||||||
| ChEMBL | Binding affinity to DLK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| protein kinase C alpha/Protein kinase C alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL299] [GtoPdb: 1482] [UniProtKB: P17252] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to PKAC-alpha | B | 6.14 | pKd | 720 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| protein kinase C beta/Protein kinase C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3045] [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| protein kinase C delta/Protein kinase C delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2996] [GtoPdb: 1485] [UniProtKB: Q05655] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCD kinase domain | B | 6.49 | pKd | 320 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKCD | B | 6.49 | pKd | 320 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCD kinase domain | B | 6.49 | pKd | 320 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C epsilon/Protein kinase C epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3582] [GtoPdb: 1486] [UniProtKB: Q02156] | ||||||||
| ChEMBL | Binding constant for PRKCE kinase domain | B | 6.27 | pKd | 540 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKCE | B | 6.27 | pKd | 540 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCE kinase domain | B | 6.27 | pKd | 540 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C eta/Protein kinase C eta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3616] [GtoPdb: 1487] [UniProtKB: P24723] | ||||||||
| ChEMBL | Binding constant for PRKCH kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKCH | B | 6.54 | pKd | 290 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCH kinase domain | B | 6.54 | pKd | 290 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C iota/Protein kinase C iota in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2598] [GtoPdb: 1490] [UniProtKB: P41743] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCI kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Binding constant for PRKD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKD1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D3/Protein kinase C nu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2595] [GtoPdb: 2174] [UniProtKB: O94806] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKD3 kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKD3 | B | 5.49 | pKd | 3200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD3 kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase C theta/Protein kinase C theta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3920] [GtoPdb: 1488] [UniProtKB: Q04759] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKCQ kinase domain | B | 6.04 | pKd | 920 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKCQ | B | 6.04 | pKd | 920 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKCQ kinase domain | B | 6.04 | pKd | 920 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase N1/Protein kinase N1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3384] [GtoPdb: 1520] [UniProtKB: Q16512] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.72 | pKd | 189 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKN1 kinase domain | B | 8.03 | pKd | 9.3 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PKN1 | B | 8.03 | pKd | 9.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKN1 kinase domain | B | 8.03 | pKd | 9.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase N2/Protein kinase N2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3032] [GtoPdb: 1521] [UniProtKB: Q16513] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKN2 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PKN2 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKN2 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein tyrosine kinase 2 beta/Protein tyrosine kinase 2 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5469] [GtoPdb: 2181] [UniProtKB: Q14289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length PTK2B | B | 6.18 | pKd | 660 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PYK2 | B | 6.18 | pKd | 660 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PYK2 kinase domain | B | 6.18 | pKd | 660 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| MER proto-oncogene, tyrosine kinase/Proto-oncogene tyrosine-protein kinase MER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5331] [GtoPdb: 1837] [UniProtKB: Q12866] | ||||||||
| ChEMBL | Binding constant for MERTK kinase domain | B | 5.54 | pKd | 2900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MERTK | B | 5.54 | pKd | 2900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MERTK kinase domain | B | 5.54 | pKd | 2900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| c-ros oncogene 1, receptor tyrosine kinase/Proto-oncogene tyrosine-protein kinase ROS in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5568] [GtoPdb: 1840] [UniProtKB: P08922] | ||||||||
| ChEMBL | Binding constant for ROS1 kinase domain | B | 6.37 | pKd | 430 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ROS1 | B | 6.37 | pKd | 430 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROS1 kinase domain | B | 6.37 | pKd | 430 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Putative heat shock protein HSP 90-beta 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105858] [UniProtKB: Q58FF8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| sugen kinase 110/Putative uncharacterized serine/threonine-protein kinase SgK110 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5116] [GtoPdb: 2290] [UniProtKB: P0C264] | ||||||||
| ChEMBL | Binding affinity to SgK110 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SgK110 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pyridoxal kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075181] [UniProtKB: O00764] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Quinone reductase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3959] [UniProtKB: P16083] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Rab-like protein 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105853] [UniProtKB: Q5HYI8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ras-related protein Rab-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105971] [UniProtKB: P61026] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Ras-related protein Rab-6A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105703] [UniProtKB: P20340] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| receptor interacting serine/threonine kinase 1/Receptor-interacting serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5464] [GtoPdb: 2189] [UniProtKB: Q13546] | ||||||||
| ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RIPK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| receptor interacting serine/threonine kinase 3/Receptor-interacting serine/threonine-protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795199] [GtoPdb: 2191] [UniProtKB: Q9Y572] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| receptor interacting serine/threonine kinase 4/Receptor-interacting serine/threonine-protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6083] [GtoPdb: 2192] [UniProtKB: P57078] | ||||||||
| ChEMBL | Binding affinity to RIPK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| erb-b2 receptor tyrosine kinase 2/Receptor protein-tyrosine kinase erbB-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1824] [GtoPdb: 2019] [UniProtKB: P04626] | ||||||||
| ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ERBB2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
| ChEMBL | Binding affinity to ERBB4 | B | 5.51 | pKd | 3100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB4 kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| erb-b2 receptor tyrosine kinase 3/Receptor tyrosine-protein kinase erbB-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5838] [GtoPdb: 1798] [UniProtKB: P21860] | ||||||||
| ChEMBL | Binding affinity to ERBB3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERBB3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Rho associated coiled-coil containing protein kinase 1/Rho-associated protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3231] [GtoPdb: 1503] [UniProtKB: Q13464] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ROCK1 | B | 5.11 | pKd | 7800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROCK1 kinase domain | B | 5.11 | pKd | 7800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ROCK2 | B | 5.64 | pKd | 2300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ROCK2 kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| G protein-coupled receptor kinase 1/Rhodopsin kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5607] [GtoPdb: 1465] [UniProtKB: Q15835] | ||||||||
| ChEMBL | Binding affinity to GRK1 | B | 7.07 | pKd | 85 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GRK1 kinase domain | B | 7.07 | pKd | 85 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase B1/Ribosomal protein S6 kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4501] [GtoPdb: 1525] [UniProtKB: P23443] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to SBK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for S6K1 kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A1/Ribosomal protein S6 kinase alpha 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2553] [GtoPdb: 1527] [UniProtKB: Q15418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA1(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK1(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA3(Kin.Dom.1-N-terminal) | B | 6.13 | pKd | 740 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA1(Kin.Dom.1 - N-terminal) kinase domain | B | 6.16 | pKd | 690 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK1(Kin.Dom.1-N-terminal) kinase domain | B | 6.16 | pKd | 690 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA4(Kin.Dom.1-N-terminal) | B | 6.59 | pKd | 260 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ribosomal protein S6 kinase A2/Ribosomal protein S6 kinase alpha 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3906] [GtoPdb: 1529] [UniProtKB: Q15349] | ||||||||
| ChEMBL | Binding constant for RPS6KA2(Kin.Dom.2 - C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RPS6KA5(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RSK3(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA5(Kin.Dom.1-N-terminal) | B | 6.62 | pKd | 240 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ribosomal protein S6 kinase A3/Ribosomal protein S6 kinase alpha 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2345] [GtoPdb: 1528] [UniProtKB: P51812] | ||||||||
| ChEMBL | Binding affinity to RPS6KA4(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.46 | pKd | 3497 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA3(Kin.Dom.1 - N-terminal) kinase domain | B | 6.13 | pKd | 740 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK2(Kin.Dom.1-N-terminal) kinase domain | B | 6.13 | pKd | 740 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ribosomal protein S6 kinase A4/Ribosomal protein S6 kinase alpha 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3125] [GtoPdb: 1524] [UniProtKB: O75676] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RPS6KA1(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA1(Kin.Dom.1-N-terminal) | B | 6.16 | pKd | 690 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1-N-terminal) kinase domain | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RPS6KA4(Kin.Dom.1 - C-terminal) kinase domain | B | 6.59 | pKd | 260 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A5/Ribosomal protein S6 kinase alpha 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4237] [GtoPdb: 1523] [UniProtKB: O75582] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RPS6KA2(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA2(Kin.Dom.1-N-terminal) | B | 6.14 | pKd | 730 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1-N-terminal) kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RPS6KA5(Kin.Dom.1 - C-terminal) kinase domain | B | 6.62 | pKd | 240 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ribosomal protein S6 kinase A6/Ribosomal protein S6 kinase alpha 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4924] [GtoPdb: 1530] [UniProtKB: Q9UK32] | ||||||||
| ChEMBL | Binding affinity to RPS6KA6(Kin.Dom.2-C-terminal) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RPS6KA6(Kin.Dom.2 - N-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK4(Kin.Dom.2-C-terminal) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RPS6KA6(Kin.Dom.1 - C-terminal) kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RSK4(Kin.Dom.1-N-terminal) kinase domain | B | 5.82 | pKd | 1500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RPS6KA6(Kin.Dom.1-N-terminal) | B | 5.82 | pKd | 1500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.38 | pKd | 419 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| RNA cytidine acetyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105935] [UniProtKB: Q9H0A0] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| S-adenosylmethionine synthase isoform type-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3313835] [UniProtKB: P31153] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Septin-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105891] [UniProtKB: Q9UHD8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| serine/threonine kinase 10/Serine/threonine-protein kinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3981] [GtoPdb: 2211] [UniProtKB: O94804] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LOK kinase domain | B | 6.23 | pKd | 590 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LOK | B | 6.23 | pKd | 590 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LOK kinase domain | B | 6.23 | pKd | 590 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 11/Serine/threonine-protein kinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5606] [GtoPdb: 2212] [UniProtKB: Q15831] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length LKB1 | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LKB1 | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LKB1 kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 16/Serine/threonine-protein kinase 16 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3938] [GtoPdb: 2213] [UniProtKB: O75716] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for STK16 kinase domain | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to STK16 | B | 6.55 | pKd | 280 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK16 kinase domain | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 17a/Serine/threonine-protein kinase 17A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4525] [GtoPdb: 2214] [UniProtKB: Q9UEE5] | ||||||||
| ChEMBL | Binding constant for DRAK1 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DRAK1 | B | 5.72 | pKd | 1900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DRAK1 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 17b/Serine/threonine-protein kinase 17B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3980] [GtoPdb: 2215] [UniProtKB: O94768] | ||||||||
| ChEMBL | Binding constant for full-length DRAK2 | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DRAK2 | B | 5.33 | pKd | 4700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DRAK2 kinase domain | B | 5.33 | pKd | 4700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| STE20 like kinase/Serine/threonine-protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4202] [GtoPdb: 2200] [UniProtKB: Q9H2G2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SLK kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SLK | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SLK kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 24/Serine/threonine-protein kinase 24 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5082] [GtoPdb: 2217] [UniProtKB: Q9Y6E0] | ||||||||
| ChEMBL | Binding constant for MST3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MST3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 25/Serine/threonine-protein kinase 25 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5552] [GtoPdb: 2218] [UniProtKB: O00506] | ||||||||
| ChEMBL | Binding constant for YSK1 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to YSK1 | B | 5.74 | pKd | 1800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YSK1 kinase domain | B | 5.74 | pKd | 1800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32A/Serine/threonine-protein kinase 32A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6150] [GtoPdb: 1537] [UniProtKB: Q8WU08] | ||||||||
| ChEMBL | Binding constant for YANK1 kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32B/Serine/threonine-protein kinase 32B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5912] [GtoPdb: 1538] [UniProtKB: Q9NY57] | ||||||||
| ChEMBL | Binding constant for full-length YANK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to YANK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YANK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 32C/Serine/threonine-protein kinase 32C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5405] [GtoPdb: 1539] [UniProtKB: Q86UX6] | ||||||||
| ChEMBL | Binding constant for YANK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to YANK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YANK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 33/Serine/threonine-protein kinase 33 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6005] [GtoPdb: 2221] [UniProtKB: Q9BYT3] | ||||||||
| ChEMBL | Binding constant for full-length STK33 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to STK33 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK33 kinase domain | B | 6.72 | pKd | 190 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 35/Serine/threonine-protein kinase 35 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5651] [GtoPdb: 2222] [UniProtKB: Q8TDR2] | ||||||||
| ChEMBL | Binding affinity to STK35 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK35 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 36/Serine/threonine-protein kinase 36 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4312] [GtoPdb: 2223] [UniProtKB: Q9NRP7] | ||||||||
| ChEMBL | Binding constant for STK36 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to STK36 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK36 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine kinase 38/Serine/threonine-protein kinase 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075155] [GtoPdb: 1517] [UniProtKB: Q15208] | ||||||||
| ChEMBL | Binding affinity to NDR1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NDR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine kinase 38 like/Serine/threonine-protein kinase 38-like in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4851] [GtoPdb: 1518] [UniProtKB: Q9Y2H1] | ||||||||
| ChEMBL | Binding constant for NDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NDR2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NDR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT1 kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AKT1 | B | 6.02 | pKd | 950 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT1 kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT2 kinase domain | B | 6.11 | pKd | 780 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AKT2 | B | 6.11 | pKd | 780 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT2 kinase domain | B | 6.11 | pKd | 780 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AKT3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AKT3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AKT3 kinase domain | B | 5.36 | pKd | 4400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| A-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase A-Raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169596] [GtoPdb: 1933] [UniProtKB: P10398] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.32 | pKd | 477 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AURKA kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AURKA | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKA kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Further kinetic evaluation of compounds supplied by Sanofi against AuroraA within a BIAcore3000 instrument | B | 7.71 | pKd | 19.29 | nM | Kd | K4DD drug target binding kinetics data |
| ChEMBL | Inhibition of recombinant GST-tagged Aurora-A kinase domain (S123 to S401) (unknown origin) expressed in insect Sf9 cells using tetra(LRRASLG) peptide as substrate after 90 mins by Kinase-Glo assay | B | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2015) 100: 151-161 [PMID:26081023] |
| aurora kinase B/Serine/threonine-protein kinase Aurora-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2185] [GtoPdb: 1937] [UniProtKB: Q96GD4] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.62 | pKd | 2409 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for AURKB kinase domain | B | 7.21 | pKd | 62 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AURKB | B | 7.21 | pKd | 62 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKB kinase domain | B | 7.21 | pKd | 62 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| aurora kinase C/Serine/threonine-protein kinase Aurora-C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3935] [GtoPdb: 1938] [UniProtKB: Q9UQB9] | ||||||||
| ChEMBL | Binding constant for full-length AURKC | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AURKC | B | 6.77 | pKd | 170 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AURKC kinase domain | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BRAF | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for BRAF kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for BRAF(V600E) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to BRAF V600E mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| checkpoint kinase 1/Serine/threonine-protein kinase Chk1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630] [GtoPdb: 1987] [UniProtKB: O14757] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for CHEK1 kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CHEK1 | B | 5.89 | pKd | 1300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CHEK1 kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| ChEMBL | Binding affinity to CHEK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CHEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.96 | pKd | 1090 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MARK3 | B | 7.68 | pKd | 21 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MARK3 | B | 7.68 | pKd | 21 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK3 kinase domain | B | 7.68 | pKd | 21 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase D2/Serine/threonine-protein kinase D2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4900] [GtoPdb: 2173] [UniProtKB: Q9BZL6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PRKD2 kinase domain | B | 5.2 | pKd | 6300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKD2 | B | 5.2 | pKd | 6300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKD2 kinase domain | B | 5.2 | pKd | 6300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 1/Serine/threonine-protein kinase DCLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5683] [GtoPdb: 2005] [UniProtKB: O15075] | ||||||||
| ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DCAMKL1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 2/Serine/threonine-protein kinase DCLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5519] [GtoPdb: 2006] [UniProtKB: Q8N568] | ||||||||
| ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DCAMKL2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| doublecortin like kinase 3/Serine/threonine-protein kinase DCLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6123] [GtoPdb: 2007] [UniProtKB: Q9C098] | ||||||||
| ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DCAMKL3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DCAMKL3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| endoplasmic reticulum to nucleus signaling 1/Serine/threonine-protein kinase/endoribonuclease IRE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163101] [GtoPdb: 2020] [UniProtKB: O75460] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ERN1 | B | 5.64 | pKd | 2300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ERN1 kinase domain | B | 5.64 | pKd | 2300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| endoplasmic reticulum to nucleus signaling 2/Serine/threonine-protein kinase/endoribonuclease IRE2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105932] [GtoPdb: 2021] [UniProtKB: Q76MJ5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| cyclin G associated kinase/Serine/threonine-protein kinase GAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4355] [GtoPdb: 2027] [UniProtKB: O14976] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for GAK kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to GAK | B | 6.42 | pKd | 380 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for GAK kinase domain | B | 6.42 | pKd | 380 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ciliogenesis associated kinase 1/Serine/threonine-protein kinase ICK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163126] [GtoPdb: 2038] [UniProtKB: Q9UPZ9] | ||||||||
| ChEMBL | Binding affinity to ICK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ICK kinase domain | B | 5.23 | pKd | 5900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| integrin linked kinase/Serine/threonine-protein kinase ILK-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5247] [GtoPdb: 2041] [UniProtKB: Q13418] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LATS1 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LATS1 | B | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LATS1 kinase domain | B | 5.96 | pKd | 1100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| GtoPdb | - | - | 5.96 | pKd | 1100 | nM | Kd | Blood (2009) 114: 2984-92 [PMID:19654408] |
| large tumor suppressor kinase 2/Serine/threonine-protein kinase LATS2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5907] [GtoPdb: 1516] [UniProtKB: Q9NRM7] | ||||||||
| ChEMBL | Binding constant for LATS2 kinase domain | B | 5.66 | pKd | 2200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LATS2 | B | 5.66 | pKd | 2200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LATS2 kinase domain | B | 5.66 | pKd | 2200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| GtoPdb | - | - | 5.66 | pKd | 2200 | nM | Kd | Blood (2009) 114: 2984-92 [PMID:19654408] |
| male germ cell associated kinase/Serine/threonine-protein kinase MAK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163106] [GtoPdb: 2061] [UniProtKB: P20794] | ||||||||
| ChEMBL | Binding affinity to MAK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MAK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| microtubule affinity regulating kinase 1/Serine/threonine-protein kinase MARK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5940] [GtoPdb: 2097] [UniProtKB: Q9P0L2] | ||||||||
| ChEMBL | Binding constant for MARK1 kinase domain | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MARK1 | B | 6.77 | pKd | 170 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MARK1 kinase domain | B | 6.77 | pKd | 170 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MRCKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MRCKA | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MRCKA kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase beta/Serine/threonine-protein kinase MRCK beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5052] [GtoPdb: 1508] [UniProtKB: Q9Y5S2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MRCKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MRCKB | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MRCKB kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| CDC42 binding protein kinase gamma/Serine/threonine-protein kinase MRCK gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5615] [GtoPdb: 1506] [UniProtKB: Q6DT37] | ||||||||
| ChEMBL | Binding constant for DMPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to DMPK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for DMPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine kinase 4/Serine/threonine-protein kinase MST1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4598] [GtoPdb: 2225] [UniProtKB: Q13043] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MST1 | B | 7.4 | pKd | 40 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MST1 kinase domain | B | 7.4 | pKd | 40 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MST1 | B | 7.77 | pKd | 17 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| serine/threonine kinase 3/Serine/threonine-protein kinase MST2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4708] [GtoPdb: 2219] [UniProtKB: Q13188] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for MST2 kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for MST2 kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to MST2 | B | 7.4 | pKd | 40 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| serine/threonine-protein kinase MST4/Serine/threonine-protein kinase MST4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5941] [GtoPdb: 2287] [UniProtKB: Q9P289] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length MST4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to MST4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for MST4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mechanistic target of rapamycin kinase/Serine/threonine-protein kinase mTOR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2842] [GtoPdb: 2109] [UniProtKB: P42345] | ||||||||
| ChEMBL | Binding constant for MTOR kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 1/Serine/threonine-protein kinase Nek1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5855] [GtoPdb: 2114] [UniProtKB: Q96PY6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 11/Serine/threonine-protein kinase Nek11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5638] [GtoPdb: 2116] [UniProtKB: Q8NG66] | ||||||||
| ChEMBL | Binding constant for NEK11 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 2/Serine/threonine-protein kinase NEK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3835] [GtoPdb: 2117] [UniProtKB: P51955] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 3/Serine/threonine-protein kinase Nek3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5679] [GtoPdb: 2118] [UniProtKB: P51956] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 4/Serine/threonine-protein kinase Nek4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5819] [GtoPdb: 2119] [UniProtKB: P51957] | ||||||||
| ChEMBL | Binding constant for NEK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 5/Serine/threonine-protein kinase Nek5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5044] [GtoPdb: 2120] [UniProtKB: Q6P3R8] | ||||||||
| ChEMBL | Binding constant for NEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK5 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 6/Serine/threonine-protein kinase NEK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4309] [GtoPdb: 2121] [UniProtKB: Q9HC98] | ||||||||
| ChEMBL | Binding constant for NEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK6 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 7/Serine/threonine-protein kinase NEK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4849] [GtoPdb: 2122] [UniProtKB: Q8TDX7] | ||||||||
| ChEMBL | Binding constant for full-length NEK7 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK7 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| NIMA related kinase 9/Serine/threonine-protein kinase NEK9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5257] [GtoPdb: 2124] [UniProtKB: Q8TD19] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for NEK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NEK9 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NEK9 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serine/threonine-protein kinase NIM1/Serine/threonine-protein kinase NIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3542] [GtoPdb: 2291] [UniProtKB: Q8IY84] | ||||||||
| ChEMBL | Binding affinity to NIM1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NIM1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| nemo like kinase/Serine/threonine protein kinase NLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5364] [GtoPdb: 2125] [UniProtKB: Q9UBE8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length NLK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to NLK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for NLK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| oxidative stress responsive kinase 1/Serine/threonine-protein kinase OSR1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163104] [GtoPdb: 2132] [UniProtKB: O95747] | ||||||||
| ChEMBL | Binding affinity to OSR1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for OSR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 1/Serine/threonine-protein kinase PAK 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4600] [GtoPdb: 2133] [UniProtKB: Q13153] | ||||||||
| ChEMBL | Binding constant for PAK1 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PAK1 kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PAK1 | B | 5.7 | pKd | 2000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| p21 (RAC1) activated kinase 2/Serine/threonine-protein kinase PAK 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4487] [GtoPdb: 2134] [UniProtKB: Q13177] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PAK2 kinase domain | B | 5.48 | pKd | 3300 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PAK2 kinase domain | B | 5.48 | pKd | 3300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to PAK2 | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| p21 (RAC1) activated kinase 3/Serine/threonine-protein kinase PAK 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2999] [GtoPdb: 2135] [UniProtKB: O75914] | ||||||||
| ChEMBL | Binding affinity to PAK3 | B | 5.48 | pKd | 3300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for full-length PAK3 | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for PAK3 kinase domain | B | 6.74 | pKd | 180 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 4/Serine/threonine-protein kinase PAK 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4482] [GtoPdb: 2136] [UniProtKB: O96013] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PAK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 6/Serine/threonine-protein kinase PAK6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4311] [GtoPdb: 2137] [UniProtKB: Q9NQU5] | ||||||||
| ChEMBL | Binding constant for PAK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PAK6 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| p21 (RAC1) activated kinase 5/Serine/threonine-protein kinase PAK7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4524] [GtoPdb: 2138] [UniProtKB: Q9P286] | ||||||||
| ChEMBL | Binding constant for PAK7/PAK5 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PAK7 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PAK7 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 16/Serine/threonine-protein kinase PCTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4597] [GtoPdb: 1969] [UniProtKB: Q00536] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PCTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PCTK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 17/Serine/threonine-protein kinase PCTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5790] [GtoPdb: 1970] [UniProtKB: Q00537] | ||||||||
| ChEMBL | Binding constant for full-length PCTK2 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PCTK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 18/Serine/threonine-protein kinase PCTAIRE-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5316] [GtoPdb: 1971] [UniProtKB: Q07002] | ||||||||
| ChEMBL | Binding constant for full-length PCTK3 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PCTK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PCTK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 14/Serine/threonine-protein kinase PFTAIRE-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6162] [GtoPdb: 1967] [UniProtKB: O94921] | ||||||||
| ChEMBL | Binding constant for full-length PFTK1 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PFTK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PFTK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| cyclin dependent kinase 15/Serine/threonine-protein kinase PFTAIRE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5856] [GtoPdb: 1968] [UniProtKB: Q96Q40] | ||||||||
| ChEMBL | Binding affinity to PFTAIRE2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PFTAIRE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PIM1 kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIM1 | B | 6.25 | pKd | 560 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM1 kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
| ChEMBL | Binding constant for PIM2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIM2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM2 kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
| ChEMBL | Binding constant for PIM3 kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PIM3 | B | 6.25 | pKd | 560 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PIM3 kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Serine/threonine-protein kinase pknB in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908385] [UniProtKB: P9WI81] | ||||||||
| ChEMBL | Binding constant for PKNB(M.tuberculosis) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 1/Serine/threonine-protein kinase PLK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3024] [GtoPdb: 2168] [UniProtKB: P53350] | ||||||||
| ChEMBL | Binding constant for PLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PLK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 2/Serine/threonine-protein kinase PLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5938] [GtoPdb: 2169] [UniProtKB: Q9NYY3] | ||||||||
| ChEMBL | Binding affinity to PLK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 3/Serine/threonine-protein kinase PLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4897] [GtoPdb: 2170] [UniProtKB: Q9H4B4] | ||||||||
| ChEMBL | Binding constant for PLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PLK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| polo like kinase 4/Serine/threonine-protein kinase PLK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3788] [GtoPdb: 2171] [UniProtKB: O00444] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.67 | pKd | 213 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PLK4 kinase domain | B | 7.18 | pKd | 66 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PLK4 | B | 7.18 | pKd | 66 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PLK4 kinase domain | B | 7.18 | pKd | 66 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein kinase X-linked/Serine/threonine-protein kinase PRKX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5818] [GtoPdb: 2175] [UniProtKB: P51817] | ||||||||
| ChEMBL | Binding constant for full-length PRKX | B | 6.02 | pKd | 960 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PRKX | B | 6.02 | pKd | 960 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRKX kinase domain | B | 6.02 | pKd | 960 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| pre-mRNA processing factor kinase PRP4K/Serine/threonine-protein kinase PRP4 homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908382] [GtoPdb: 2177] [UniProtKB: Q13523] | ||||||||
| ChEMBL | Binding affinity to PRP4 | B | 7.26 | pKd | 55 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PRP4 kinase domain | B | 7.26 | pKd | 55 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Raf-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase RAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1906] [GtoPdb: 2184] [UniProtKB: P04049] | ||||||||
| ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RAF1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RAF1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| activin A receptor type IL/Serine/threonine-protein kinase receptor R3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5311] [GtoPdb: 1784] [UniProtKB: P37023] | ||||||||
| ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ACVRL1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ACVRL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 1/Serine/threonine-protein kinase RIO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5975] [GtoPdb: 2186] [UniProtKB: Q9BRS2] | ||||||||
| ChEMBL | Binding constant for full-length RIOK1 | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RIOK1 | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK1 kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 2/Serine/threonine-protein kinase RIO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6000] [GtoPdb: 2187] [UniProtKB: Q9BVS4] | ||||||||
| ChEMBL | Binding affinity to RIOK2 | B | 7.01 | pKd | 97 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK2 kinase domain | B | 7.01 | pKd | 97 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| RIO kinase 3/Serine/threonine-protein kinase RIO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5659] [GtoPdb: 2188] [UniProtKB: O14730] | ||||||||
| ChEMBL | Binding constant for full-length RIOK3 | B | 6.38 | pKd | 420 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RIOK3 | B | 6.38 | pKd | 420 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIOK3 kinase domain | B | 6.38 | pKd | 420 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RIOK3 (unknown origin) | B | 6.38 | pKd | 420 | nM | Kd | US-20200216545-A1. Compositions and methods for treating beta-globinopathies (2020) |
| ChEMBL | Binding affinity to RIOK3 (unknown origin) | B | 6.4 | pKd | 398.11 | nM | Kd | US-20200216545-A1. Compositions and methods for treating beta-globinopathies (2020) |
| receptor interacting serine/threonine kinase 2/Serine/threonine-protein kinase RIPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5014] [GtoPdb: 2190] [UniProtKB: O43353] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for RIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RIPK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RIPK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SH3 domain binding kinase 1/Serine/threonine-protein kinase SBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163129] [GtoPdb: 2193] [UniProtKB: Q52WX2] | ||||||||
| ChEMBL | Binding constant for SBK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| serum/glucocorticoid regulated kinase family member 3/Serine/threonine-protein kinase Sgk3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6186] [GtoPdb: 1536] [UniProtKB: Q96BR1] | ||||||||
| ChEMBL | Binding constant for SGK3 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| salt inducible kinase 1/Serine/threonine-protein kinase SIK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6082] [GtoPdb: 2197] [UniProtKB: P57059] | ||||||||
| ChEMBL | Binding constant for SNF1LK kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SIK | B | 6.8 | pKd | 160 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SIK kinase domain | B | 6.8 | pKd | 160 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| salt inducible kinase 2/Serine/threonine-protein kinase SIK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5699] [GtoPdb: 2198] [UniProtKB: Q9H0K1] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.94 | pKd | 1149 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length SNF1LK2 | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SIK2 | B | 6.25 | pKd | 560 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SIK2 kinase domain | B | 6.25 | pKd | 560 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SIK family kinase 3/Serine/threonine-protein kinase SIK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6149] [GtoPdb: 2199] [UniProtKB: Q9Y2K2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to QSK | B | 7.01 | pKd | 98 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for QSK kinase domain | B | 7.01 | pKd | 98 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 1/Serine/threonine-protein kinase SRPK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4375] [GtoPdb: 2208] [UniProtKB: Q96SB4] | ||||||||
| ChEMBL | Binding constant for full-length SRPK1 | B | 7.38 | pKd | 42 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SRPK1 | B | 7.38 | pKd | 42 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK1 kinase domain | B | 7.38 | pKd | 42 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 2/Serine/threonine-protein kinase SRPK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5668] [GtoPdb: 2209] [UniProtKB: P78362] | ||||||||
| ChEMBL | Binding constant for full-length SRPK2 | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SRPK2 | B | 6.48 | pKd | 330 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK2 kinase domain | B | 6.48 | pKd | 330 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRSF protein kinase 3/Serine/threonine-protein kinase SRPK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5415] [GtoPdb: 2210] [UniProtKB: Q9UPE1] | ||||||||
| ChEMBL | Binding affinity to SRPK3 | B | 7.1 | pKd | 80 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRPK3 kinase domain | B | 7.1 | pKd | 80 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 1/Serine/threonine-protein kinase TAO1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5261] [GtoPdb: 2233] [UniProtKB: Q7L7X3] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TAO1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to TAOK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAOK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 2/Serine/threonine-protein kinase TAO2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075195] [GtoPdb: 2234] [UniProtKB: Q9UL54] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TAOK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TAO kinase 3/Serine/threonine-protein kinase TAO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5701] [GtoPdb: 2235] [UniProtKB: Q9H2K8] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TAOK3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TAOK3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.73 | pKd | 188 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TBK1 | B | 8.03 | pKd | 9.3 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TBK1 kinase domain | B | 8.03 | pKd | 9.3 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TNNI3 interacting kinase/Serine/threonine-protein kinase TNNI3K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5260] [GtoPdb: 2247] [UniProtKB: Q59H18] | ||||||||
| ChEMBL | Binding constant for full-length TNNI3K | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TNNI3K | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNNI3K kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tousled like kinase 1/Serine/threonine-protein kinase tousled-like 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5388] [GtoPdb: 2242] [UniProtKB: Q9UKI8] | ||||||||
| ChEMBL | Binding constant for TLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TLK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TLK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tousled like kinase 2/Serine/threonine-protein kinase tousled-like 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5404] [GtoPdb: 2243] [UniProtKB: Q86UE8] | ||||||||
| ChEMBL | Binding constant for TLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TLK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TLK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like autophagy activating kinase 1/Serine/threonine-protein kinase ULK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6006] [GtoPdb: 2271] [UniProtKB: O75385] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ULK1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like autophagy activating kinase 2/Serine/threonine-protein kinase ULK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5435] [GtoPdb: 2272] [UniProtKB: Q8IYT8] | ||||||||
| ChEMBL | Binding affinity to ULK2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| unc-51 like kinase 3/Serine/threonine-protein kinase ULK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5047] [GtoPdb: 2273] [UniProtKB: Q6PHR2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to ULK3 | B | 5.89 | pKd | 1300 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ULK3 kinase domain | B | 5.89 | pKd | 1300 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| VRK serine/threonine kinase 2/Serine/threonine-protein kinase VRK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649059] [GtoPdb: 2276] [UniProtKB: Q86Y07] | ||||||||
| ChEMBL | Binding constant for VRK2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| WEE1 G2 checkpoint kinase/Serine/threonine-protein kinase WEE1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5491] [GtoPdb: 2278] [UniProtKB: P30291] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for WEE1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to WEE1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for WEE1 kinase domain | B | 5.34 | pKd | 4600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SNF related kinase/SNF-related serine/threonine-protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908384] [GtoPdb: 2202] [UniProtKB: Q9NRH2] | ||||||||
| ChEMBL | Binding constant for SNRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| mitogen-activated protein kinase kinase kinase 19/SPS1/STE20-related protein kinase YSK4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6191] [GtoPdb: 2076] [UniProtKB: Q56UN5] | ||||||||
| ChEMBL | Binding affinity to YSK4 | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YSK4 kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| STE20 related adaptor alpha/STE20-related kinase adapter protein alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795198] [GtoPdb: 2227] [UniProtKB: Q7RTN6] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| serine/threonine kinase 39/STE20/SPS1-related proline-alanine-rich protein kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163108] [GtoPdb: 2224] [UniProtKB: Q9UEW8] | ||||||||
| ChEMBL | Binding affinity to STK39 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for STK39 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(V559D,V654A) kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to KIT V559D,V654A mutant | B | 5.8 | pKd | 1600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human KIT incubated for 1 hr by kinase binding assay | B | 6.66 | pKd | 220 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
| ChEMBL | Binding affinity to KIT | B | 6.66 | pKd | 220 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT kinase domain | B | 6.66 | pKd | 220 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 6.7 | pKd | 200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT V559D mutant | B | 6.7 | pKd | 200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(V559D) kinase domain | B | 6.7 | pKd | 200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 6.82 | pKd | 150 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT V559D,T670I mutant | B | 6.82 | pKd | 150 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(V559D,T670I) kinase domain | B | 6.82 | pKd | 150 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for KIT(A829P) kinase domain | B | 7.37 | pKd | 43 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to KIT L576P mutant | B | 7.39 | pKd | 41 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(L576P) kinase domain | B | 7.39 | pKd | 41 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(D816H) kinase domain | B | 7.8 | pKd | 16 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 8.11 | pKd | 7.7 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human KIT D816V mutant incubated for 1 hr by kinase binding assay | B | 8.11 | pKd | 7.7 | nM | Kd | Eur J Med Chem (2011) 46: 2043-2057 [PMID:21429632] |
| ChEMBL | Binding affinity to KIT D816V mutant | B | 8.11 | pKd | 7.7 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for KIT(D816V) kinase domain | B | 8.11 | pKd | 7.7 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr) 4:1 as substrate measured after 150 mins in presence of ATP by ADP-glo reagent based luminescence assay | B | 6.96 | pIC50 | 109 | nM | IC50 | J Med Chem (2019) 62: 11135-11150 [PMID:31721578] |
| Structural maintenance of chromosomes protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105747] [UniProtKB: Q14683] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Structural maintenance of chromosomes protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105890] [UniProtKB: O95347] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105973] [UniProtKB: Q9P2R7] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] | ||||||||
| ChEMBL | Binding affinity to TNK2 | B | 6.92 | pKd | 120 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| testis specific serine kinase 1B/Testis-specific serine/threonine-protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6003] [GtoPdb: 2257] [UniProtKB: Q9BXA7] | ||||||||
| ChEMBL | Binding constant for full-length TSSK1 | B | 5.32 | pKd | 4800 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TSSK1B | B | 5.32 | pKd | 4800 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TSSK1B kinase domain | B | 5.32 | pKd | 4800 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TGFBR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TGFBR1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TGFBR1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| transforming growth factor beta receptor 2/TGF-beta receptor type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4267] [GtoPdb: 1795] [UniProtKB: P37173] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TGFBR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TGFBR2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TGFBR2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TP53 regulating kinase/TP53-regulating kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1938223] [GtoPdb: 2248] [UniProtKB: Q96S44] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| TRAF2 and NCK interacting kinase/TRAF2- and NCK-interacting kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4527] [GtoPdb: 2244] [UniProtKB: Q9UKE5] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TNIK kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TNIK | B | 5.8 | pKd | 1600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TNIK kinase domain | B | 5.8 | pKd | 1600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TRPM6/Transient receptor potential cation channel subfamily M member 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1628470] [GtoPdb: 498] [UniProtKB: Q9BX84] | ||||||||
| ChEMBL | Binding constant for TRPM6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tubulin alpha 1a/Tubulin alpha-1 chain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4139] [GtoPdb: 2638] [UniProtKB: P68370] | ||||||||
| ChEMBL | Binding constant for ERBB4 kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| protein kinase, membrane associated tyrosine/threonine 1/Tyrosine- and threonine-specific cdc2-inhibitory kinase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3984] [GtoPdb: 2167] [UniProtKB: Q99640] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to PKMYT1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for PKMYT1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase non receptor 2/Tyrosine kinase non-receptor protein 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4599] [GtoPdb: 2246] [UniProtKB: Q07912] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.52 | pKd | 303 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TNK2 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for TNK2 kinase domain | B | 6.92 | pKd | 120 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ABL1(E255K) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(H396P) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(M351T) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(Q252H) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(Y253F) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ABL1 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 E255K mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 F317I mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 F317L mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 H396P mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 M351T mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 Q252H mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to ABL1 Y253F mutant | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1(E255K)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(M351T)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Q252H)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Q252H)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(Y253F)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(F317I)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(F317I)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(F317L)-non phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(F317L)-phosphorylated kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(H396P)-phosphorylated kinase domain | B | 5.25 | pKd | 5600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(T315I)-non phosphorylated kinase domain | B | 5.31 | pKd | 4900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to ABL1 T315I mutant | B | 5.49 | pKd | 3200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL1(T315I) kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for ABL1(H396P)-non phosphorylated kinase domain | B | 5.51 | pKd | 3100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for ABL1(T315I)-phosphorylated kinase domain | B | 6.1 | pKd | 790 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ABL proto-oncogene 2, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4014] [GtoPdb: 1924] [UniProtKB: P42684] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for ABL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ABL2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ABL2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BLK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase BLK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2250] [GtoPdb: 1940] [UniProtKB: P51451] | ||||||||
| ChEMBL | Binding constant for BLK kinase domain | B | 6.3 | pKd | 500 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BLK | B | 6.3 | pKd | 500 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BLK kinase domain | B | 6.3 | pKd | 500 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| BMX non-receptor tyrosine kinase/Tyrosine-protein kinase BMX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3834] [GtoPdb: 1942] [UniProtKB: P51813] | ||||||||
| ChEMBL | Binding constant for full-length BMX | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BMX | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BMX kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| protein tyrosine kinase 6/Tyrosine-protein kinase BRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4601] [GtoPdb: 2182] [UniProtKB: Q13882] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for PTK6 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BRK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BRK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length BTK | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to BTK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for BTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| C-terminal Src kinase/Tyrosine-protein kinase CSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2634] [GtoPdb: 1994] [UniProtKB: P41240] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for full-length CSK | B | 5.06 | pKd | 8700 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to CSK | B | 5.06 | pKd | 8700 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CSK kinase domain | B | 5.06 | pKd | 8700 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| megakaryocyte-associated tyrosine kinase/Tyrosine-protein kinase CTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4175] [GtoPdb: 2101] [UniProtKB: P42679] | ||||||||
| ChEMBL | Binding affinity to CTK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for CTK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FER tyrosine kinase/Tyrosine-protein kinase FER in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3982] [GtoPdb: 2022] [UniProtKB: P16591] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.53 | pKd | 2985 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FER kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FER | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FER kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FES proto-oncogene, tyrosine kinase/Tyrosine-protein kinase FES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5455] [GtoPdb: 2023] [UniProtKB: P07332] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FES | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FES kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FGR proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FGR in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4454] [GtoPdb: 2024] [UniProtKB: P09769] | ||||||||
| ChEMBL | Binding constant for FGR kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FGR | B | 6.14 | pKd | 730 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FGR kinase domain | B | 6.14 | pKd | 730 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fyn related Src family tyrosine kinase/Tyrosine-protein kinase FRK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4223] [GtoPdb: 2025] [UniProtKB: P42685] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FRK kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FRK | B | 5.62 | pKd | 2400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FRK kinase domain | B | 5.62 | pKd | 2400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| FYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase FYN in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1841] [GtoPdb: 2026] [UniProtKB: P06241] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FYN kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FYN | B | 5.68 | pKd | 2100 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FYN kinase domain | B | 5.68 | pKd | 2100 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| HCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase HCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3234] [GtoPdb: 2032] [UniProtKB: P08631] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for HCK kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to HCK | B | 6.14 | pKd | 720 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for HCK kinase domain | B | 6.14 | pKd | 720 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| IL2 inducible T cell kinase/Tyrosine-protein kinase ITK/TSK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2959] [GtoPdb: 2046] [UniProtKB: Q08881] | ||||||||
| ChEMBL | Binding constant for ITK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ITK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ITK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Janus kinase 1/Tyrosine-protein kinase JAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2835] [GtoPdb: 2047] [UniProtKB: P23458] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for JAK1(Kin.Dom.1/JH2 - pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JAK1 JH2 domain | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK1(JH2domain-pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to JH1 catalytic domain JAK1 | B | 6.17 | pKd | 670 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK1(JH1domain-catalytic) kinase domain | B | 6.17 | pKd | 670 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Janus kinase 2/Tyrosine-protein kinase JAK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2971] [GtoPdb: 2048] [UniProtKB: O60674] | ||||||||
| ChEMBL | Binding constant for JAK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 7.03 | pKd | 94 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JH1 catalytic domain JAK2 | B | 7.03 | pKd | 94 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK2(JH1domain-catalytic) kinase domain | B | 7.03 | pKd | 94 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Janus kinase 3/Tyrosine-protein kinase JAK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2148] [GtoPdb: 2049] [UniProtKB: P52333] | ||||||||
| ChEMBL | Binding constant for JAK3(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to JH1 catalytic domain of JAK3 | B | 7.92 | pKd | 12 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for JAK3(JH1domain-catalytic) kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LCK kinase domain | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LCK | B | 6.55 | pKd | 280 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LCK kinase domain | B | 6.55 | pKd | 280 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for LYN kinase domain | B | 5.38 | pKd | 4200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to LYN | B | 5.38 | pKd | 4200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for LYN kinase domain | B | 5.38 | pKd | 4200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.47 | pKd | 341 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 D835Y mutant | B | 7.82 | pKd | 15 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(D835Y) kinase domain | B | 7.82 | pKd | 15 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3(R834Q) kinase domain | B | 7.92 | pKd | 12 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3 kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assay | B | 7.96 | pKd | 11 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to FLT3 | B | 7.96 | pKd | 11 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3 kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for FLT3(ITD) kinase domain | B | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to human FLT3 | B | 7.96 | pKd | 11 | nM | Kd | J Med Chem (2013) 56: 8032-8048 [PMID:24044867] |
| ChEMBL | Binding affinity to N-terminal GST-tagged human FLT3 (563 to 993 residues) cytoplasmic domain expressed in baculovirus infected sf9 cells using poly (Glu, Tyr) 4:1 as substrate in presence of [gamma-33P]-ATP by TopCount method | B | 7.96 | pKd | 11 | nM | Kd | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| ChEMBL | Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression system | B | 7.96 | pKd | 11 | nM | Kd | J Med Chem (2019) 62: 2428-2446 [PMID:30742435] |
| ChEMBL | Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expression | B | 7.96 | pKd | 11 | nM | Kd | J Med Chem (2019) 62: 2428-2446 [PMID:30742435] |
| GtoPdb | - | - | 7.96 | pKd | 11 | nM | Kd | Nat Biotechnol (2011) 29: 1046-51 [PMID:22037378] |
| ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 8.17 | pKd | 6.8 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression system | B | 8.17 | pKd | 6.8 | nM | Kd | J Med Chem (2019) 62: 2428-2446 [PMID:30742435] |
| ChEMBL | Binding constant for FLT3(D835H) kinase domain | B | 8.17 | pKd | 6.8 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 D835H mutant | B | 8.17 | pKd | 6.8 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 8.22 | pKd | 6 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for FLT3(N841I) kinase domain | B | 8.22 | pKd | 6 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to FLT3 N841I mutant | B | 8.22 | pKd | 6 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to FLT3 K663Q mutant | B | 8.7 | pKd | 2 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT3(K663Q) kinase domain | B | 8.7 | pKd | 2 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant GST-tagged human FLT3 expressed in baculovirus expression system by tyrosine kinase assay | B | 6.28 | pIC50 | 528 | nM | IC50 | Bioorg Med Chem (2022) 56: 116596-116596 [PMID:35033885] |
| GtoPdb | - | - | 6.28 | pIC50 | 528 | nM | IC50 | Cancer Cell (2002) 1: 433-43 [PMID:12124173] |
| ChEMBL | Inhibition of FLT3 (unknown origin) | B | 6.3 | pIC50 | 501 | nM | IC50 | Eur J Med Chem (2020) 195: 112205-112205 [PMID:32272419] |
| ChEMBL | Inhibition of FLT3 (unknown origin) | B | 6.88 | pIC50 | 132 | nM | IC50 | Eur J Med Chem (2022) 243: 114742-114742 [PMID:36155354] |
| ChEMBL | Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Her2 peptide as substrate measured after 4 hrs in presence of ATP by Kinase-Glo Plus reagent-based luminescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2019) 62: 11135-11150 [PMID:31721578] |
| ChEMBL | Inhibition of wild type GST-tagged FLT3 kinase domain (Y567 to S993) (unknown origin) expressed in baculovirus infected insect Sf9 cells using Her2 peptide as substrate after 4 hrs by Kinase-Glo assay | B | 7.43 | pIC50 | 37 | nM | IC50 | Eur J Med Chem (2015) 100: 151-161 [PMID:26081023] |
| ChEMBL | Inhibition of FLT3 ITD mutant (unknown origin) | B | 7.52 | pIC50 | 30 | nM | IC50 | Eur J Med Chem (2019) 184: 111710-111710 [PMID:31614258] |
| ChEMBL | Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay | B | 7.82 | pIC50 | 15 | nM | IC50 | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Inhibition of FLT3 ITD mutant autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assay | B | 7.89 | pIC50 | 13 | nM | IC50 | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Inhibition of FLT3 D835Y mutant (unknown origin) | B | 9 | pIC50 | 1 | nM | IC50 | J Med Chem (2020) 63: 12403-12428 [PMID:32659083] |
| ret proto-oncogene/Tyrosine-protein kinase receptor RET in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2041] [GtoPdb: 2185] [UniProtKB: P07949] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.7 | pKd | 19822 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to RET | B | 6.46 | pKd | 350 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RET kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding constant for RET kinase domain | B | 6.46 | pKd | 350 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RET(M918T) kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for RET(M918T) kinase domain | B | 6.89 | pKd | 130 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to RET M918T mutant | B | 6.89 | pKd | 130 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding affinity to RET(V804L) | B | 7.57 | pKd | 27 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RET(V804L) kinase domain | B | 7.57 | pKd | 27 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding affinity to RET V804M mutant | B | 7.7 | pKd | 20 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for RET(V804M) kinase domain | B | 7.7 | pKd | 20 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase with immunoglobulin like and EGF like domains 1/Tyrosine-protein kinase receptor Tie-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5274] [GtoPdb: 1841] [UniProtKB: P35590] | ||||||||
| ChEMBL | Binding constant for TIE1 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TIE1 | B | 5.85 | pKd | 1400 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TIE1 kinase domain | B | 5.85 | pKd | 1400 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TYRO3 protein tyrosine kinase/Tyrosine-protein kinase receptor TYRO3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5314] [GtoPdb: 1836] [UniProtKB: Q06418] | ||||||||
| ChEMBL | Binding constant for TYRO3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TYRO3 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYRO3 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of SKY (unknown origin) | B | 7.06 | pKd | 88 | nM | Kd | Eur J Med Chem (2019) 178: 468-483 [PMID:31207462] |
| AXL receptor tyrosine kinase/Tyrosine-protein kinase receptor UFO in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4895] [GtoPdb: 1835] [UniProtKB: P30530] | ||||||||
| ChEMBL | Binding constant for AXL kinase domain | B | 6.21 | pKd | 620 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to AXL | B | 6.21 | pKd | 620 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for AXL kinase domain | B | 6.21 | pKd | 620 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SRC kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SRC | B | 5.92 | pKd | 1200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRC kinase domain | B | 5.92 | pKd | 1200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites/Tyrosine-protein kinase Srms in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5703] [GtoPdb: 2207] [UniProtKB: Q9H3Y6] | ||||||||
| ChEMBL | Binding constant for SRMS kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SRMS | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SRMS kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 5.03 | pKd | 9226 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for SYK kinase domain | B | 7.06 | pKd | 88 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to SYK | B | 7.06 | pKd | 88 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for SYK kinase domain | B | 7.06 | pKd | 88 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tec protein tyrosine kinase/Tyrosine-protein kinase TEC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4246] [GtoPdb: 2238] [UniProtKB: P42680] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for TEC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TEC | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TEC kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TEK receptor tyrosine kinase/Tyrosine-protein kinase TIE-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4128] [GtoPdb: 1842] [UniProtKB: Q02763] | ||||||||
| ChEMBL | Binding constant for TIE2 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TIE2 | B | 5.72 | pKd | 1900 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TIE2 kinase domain | B | 5.72 | pKd | 1900 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| TXK tyrosine kinase/Tyrosine-protein kinase TXK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4367] [GtoPdb: 2268] [UniProtKB: P42681] | ||||||||
| ChEMBL | Binding constant for TXK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TXK | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TXK kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| tyrosine kinase 2/Tyrosine-protein kinase TYK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3553] [GtoPdb: 2269] [UniProtKB: P29597] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding affinity to TYK2(JH2domain-pseudokinase) | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYK2(JH2domain-pseudokinase) kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Binding constant for TYK2(Kin.Dom.2/JH1 - catalytic) kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to TYK2(JH1domain-catalytic) | B | 6.6 | pKd | 250 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for TYK2(JH1domain-catalytic) kinase domain | B | 6.6 | pKd | 250 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| YES proto-oncogene 1, Src family tyrosine kinase/Tyrosine-protein kinase YES in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073] [GtoPdb: 2284] [UniProtKB: P07947] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| ChEMBL | Binding constant for YES kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to YES | B | 6.02 | pKd | 950 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for YES kinase domain | B | 6.02 | pKd | 950 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| zeta chain of T cell receptor associated protein kinase 70/Tyrosine-protein kinase ZAP-70 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2803] [GtoPdb: 2285] [UniProtKB: P43403] | ||||||||
| ChEMBL | Binding constant for ZAP70 kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ZAP70 | B | 5.59 | pKd | 2600 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ZAP70 kinase domain | B | 5.59 | pKd | 2600 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Tyrosyl-tRNA synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3179] [UniProtKB: P54577] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| U5 small nuclear ribonucleoprotein 200 kDa helicase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105972] [UniProtKB: O75643] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| aarF domain containing kinase 1/Uncharacterized aarF domain-containing protein kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105885] [GtoPdb: 1925] [UniProtKB: Q86TW2] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| coenzyme Q8B/Uncharacterized aarF domain-containing protein kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5753] [GtoPdb: 1928] [UniProtKB: Q96D53] | ||||||||
| ChEMBL | Binding constant for full-length ADCK4 | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to ADCK4 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for ADCK4 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Uncharacterized protein FLJ45252 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105933] [UniProtKB: Q6ZSR9] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 6.53 | pKd | 293 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948] | ||||||||
| ChEMBL | Binding constant for FLT1 kinase domain | B | 6.35 | pKd | 450 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FLT1 | B | 6.35 | pKd | 450 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT1 kinase domain | B | 6.35 | pKd | 450 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] | ||||||||
| ChEMBL | Binding constant for VEGFR2 kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to VEGFR2 | B | 5.49 | pKd | 3200 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for VEGFR2 kinase domain | B | 5.49 | pKd | 3200 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| ChEMBL | Inhibition of recombinant GST-tagged VEGFR2 kinase domain (V789 to V1356) (unknown origin) expressed in insect Sf9 cells using polyGlu4:Tyr peptide as substrate after 120 mins by Kinase-Glo assay | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2015) 100: 151-161 [PMID:26081023] |
| fms related receptor tyrosine kinase 4/Vascular endothelial growth factor receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1955] [GtoPdb: 1814] [UniProtKB: P35916] | ||||||||
| ChEMBL | Binding constant for FLT4 kinase domain | B | 6.17 | pKd | 670 | nM | Kd | Nat Biotechnol (2008) 26: 127-132 [PMID:18183025] |
| ChEMBL | Binding affinity to FLT4 | B | 6.17 | pKd | 670 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for FLT4 kinase domain | B | 6.17 | pKd | 670 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
| Very long-chain specific acyl-CoA dehydrogenase, mitochondrial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105892] [UniProtKB: P49748] | ||||||||
| ChEMBL | Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry. | B | 4.52 | pKd | >30000 | nM | Kd | Science (2017) 358: null-null [PMID:29191878] |
| WEE2 oocyte meiosis inhibiting kinase/Wee1-like protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5095] [GtoPdb: 2279] [UniProtKB: P0C1S8] | ||||||||
| ChEMBL | Binding affinity to WEE2 | B | 5 | pKd | >10000 | nM | Kd | Blood (2009) 114: 2984-2992 [PMID:19654408] |
| ChEMBL | Binding constant for WEE2 kinase domain | B | 5 | pKd | >10000 | nM | Kd | Nat Biotechnol (2011) 29: 1046-1051 [PMID:22037378] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
