adrenomedullin   Click here for help

GtoPdb Ligand ID: 683

Abbreviated name: AM
Immunopharmacology Ligand
Comment: Adrenomedullin is 52 amino acid peptide which is mainly expressed in endothelial and smooth muscle cells. It acts as a vasodilatory peptide and it is known to regulate endothelial barrier function and vascular tone. Evidence from animal models indicates that it is a key player in the development of sepsis-associated hemodynamic and microcirculatory disorders.
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
ADM adrenomedullin Human prepro-adrenomedullin AM
Database Links Click here for help
Specialist databases
GPCRdb Ligand adrenomedullin
Other databases
CAS Registry No. 148498-78-6 (Hs)
Ensembl Gene ENSG00000148926 (Hs)
Entrez Gene 133 (Hs)
GtoPdb PubChem SID 135651602
Human Protein Atlas ENSG00000148926 (Hs)
UniProtKB P35318 (Hs)
Wikipedia Adrenomedullin