adrenomedullin   Click here for help

GtoPdb Ligand ID: 683

Abbreviated name: AM
Immunopharmacology Ligand
Comment: Adrenomedullin is 52 amino acid peptide which is mainly expressed in endothelial and smooth muscle cells. It acts as a vasodilatory peptide and it is known to regulate endothelial barrier function and vascular tone. Evidence from animal models indicates that it is a key player in the development of sepsis-associated hemodynamic and microcirculatory disorders.
Species: Human
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1. Aiyar N, Disa J, Pullen M, Nambi P. (2001)
Receptor activity modifying proteins interaction with human and porcine calcitonin receptor-like receptor (CRLR) in HEK-293 cells.
Mol Cell Biochem, 224 (1-2): 123-33. [PMID:11693189]
2. Fraser NJ, Wise A, Brown J, McLatchie LM, Main MJ, Foord SM. (1999)
The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor.
Mol Pharmacol, 55: 1054-1059. [PMID:10347248]
3. Geven C, Pickkers P. (2018)
The mechanism of action of the adrenomedullin-binding antibody adrecizumab.
Crit Care, 22 (1): 159. [PMID:29895302]
4. Geven C, van Lier D, Blet A, Peelen R, Ten Elzen B, Mebazaa A, Kox M, Pickkers P. (2018)
Safety, tolerability and pharmacokinetics/pharmacodynamics of the adrenomedullin antibody adrecizumab in a first-in-human study and during experimental human endotoxaemia in healthy subjects.
Br J Clin Pharmacol, 84 (9): 2129-2141. [PMID:29856470]
5. Hay DL, Christopoulos G, Christopoulos A, Poyner DR, Sexton PM. (2005)
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes.
Mol Pharmacol, 67 (5): 1655-65. [PMID:15692146]
6. Kuwasako K, Kitamura K, Nagoshi Y, Eto T. (2003)
Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins.
Biochem Biophys Res Commun, 301 (2): 460-4. [PMID:12565884]
7. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. (1998)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor.
Nature, 393 (6683): 333-9. [PMID:9620797]
8. Struck J, Hein F, Karasch S, Bergmann A. (2013)
Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model.
Intensive Care Med Exp, 1 (1): 22. [PMID:26266791]