Synonyms: CHIR 99021 | CHIR99021 | CT-99021 | CT99021 | laduviglusib (proposed INN)
Compound class:
Synthetic organic
Comment: CHIR-99021 is an ATP-competitive inhibitor of glycogen synthase kinase-3α and β (GSK-3α/β), equipotent at both isozymes [7]. The chemical structure of CHIR-99021 matches that submitted to the WHO for the INN laduviglusib. GSK-3β has been implicated in multiple human disorders, by influencing a number of significant cellular pathways (including insulin signalling and glycogen synthesis, neurotrophic factor signalling, Wnt signalling, neurotransmitter signalling and microtubule dynamics) [1]. CHIR-99021 acts as a functional Wnt pathway activator [2,9].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile |
Synonyms ![]() |
CHIR 99021 | CHIR99021 | CT-99021 | CT99021 | laduviglusib (proposed INN) |
Database Links ![]() |
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CAS Registry No. | 252917-06-9 |
ChEMBL Ligand | CHEMBL412142 |
GtoPdb PubChem SID | 249565694 |
PubChem CID | 9956119 |
RCSB PDB Ligand | 65C |
Search Google for chemical match using the InChIKey | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | AQGNHMOJWBZFQQ |
Search UniChem for chemical match using the InChIKey | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
Search UniChem for chemicals with the same backbone | AQGNHMOJWBZFQQ |
SynPHARM | 81001 (in complex with glycogen synthase kinase 3 beta) |
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CHIR 99021
Cat. No. 4423 |