TRH   Click here for help

GtoPdb Ligand ID: 2139

Synonyms: thyroliberin
Approved drug
TRH is an approved drug (FDA (1976))
Comment: This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH.
Species: Human, Mouse, Rat
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2D Structure
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Canonical SMILES O=C1CCC(N1)C(=O)NC(C(=O)N1CCCC1C(=O)N)Cc1nc[nH]c1
Isomeric SMILES O=C1CC[C@H](N1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1nc[nH]c1
InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Approved drug? Yes (FDA (1976))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
3335 protirelin
Synonyms Click here for help
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TRH thyrotropin releasing hormone Human thyrotropin-releasing hormone (Prothyroliberin) thyrotropin-releasing hormone
Trh thyrotropin releasing hormone Mouse thyrotropin-releasing hormone (Prothyroliberin) -
Trh thyrotropin releasing hormone Rat thyrotropin-releasing hormone (Prothyroliberin) prothyroliberin, THR, thyrotropin-releasing hormone, Thyrotropin releasing hormone, TRH01, Tryrotropin releasing hormone
Database Links Click here for help
Specialist databases
GPCRdb Ligand TRH
Other databases
CAS Registry No. 24305-27-9 (source: Scifinder)
ChEMBL Ligand CHEMBL1472
DrugCentral Ligand 2316
Ensembl Gene ENSRNOG00000011824 (Rn), ENSMUSG00000005892 (Mm), ENSG00000170893 (Hs)
GtoPdb PubChem SID 135651896
Human Protein Atlas ENSG00000170893 (Hs)
PubChem CID 638678
Search Google for chemical match using the InChIKey XNSAINXGIQZQOO-SRVKXCTJSA-N
Search Google for chemicals with the same backbone XNSAINXGIQZQOO
Search PubMed clinical trials protirelin
Search PubMed titles protirelin
Search PubMed titles/abstracts protirelin
UniChem Compound Search for chemical match using the InChIKey XNSAINXGIQZQOO-SRVKXCTJSA-N
UniChem Connectivity Search for chemical match using the InChIKey XNSAINXGIQZQOO-SRVKXCTJSA-N
UniProtKB Q62361 (Mm), P01150 (Rn), P20396 (Hs)
Wikipedia Thyrotropin-releasing_hormone