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TRH is an approved drug (FDA (1976))
Compound class: Endogenous peptide in human, mouse or rat
Comment: This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH.
Species: Human, Mouse, Rat
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: trh
1. Gershengorn MC, Osman R. (1996)
Molecular and cellular biology of thyrotropin-releasing hormone receptors.
Physiol Rev, 76 (1): 175-91. [PMID:8592728]
2. Urayama A, Yamada S, Kimura R, Zhang J, Watanabe Y. (2002)
Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.
Life Sci, 72 (4-5): 601-7. [PMID:12467901]