TRH   Click here for help

GtoPdb Ligand ID: 2139

Synonyms: thyroliberin
Approved drug
TRH is an approved drug (FDA (1976))
Comment: This structure matches the structure deposited with the INN record for protirelin, which is synthetic TRH.
Species: Human, Mouse, Rat
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2D Structure
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Canonical SMILES O=C1CCC(N1)C(=O)NC(C(=O)N1CCCC1C(=O)N)Cc1nc[nH]c1
Isomeric SMILES O=C1CC[C@H](N1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N)Cc1nc[nH]c1
InChI InChI=1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
No information available.
Summary of Clinical Use Click here for help
Protirelin is mainly used as a diagnostic tool to test pituitary function in patients with thyroid hormone disorders, in order to rule out pituitary gland problems. Protirelin has been used to treat spinocerebellar degeneration and disturbance of consciousness [2].
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Protirelin stimulates the release of thyroid-stimulating hormone and prolactin from anterior pituitary cells which express the TRHR.