ChEMBL ligand: CHEMBL1950554 (Binodenoson, Corvue, MRE-0470, MRE0470, Wrc0470)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] Adenosine A1 receptor in Guinea pig [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor	B	4.32	pKi	48000	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
ChEMBL	Binding affinity to human recombinant adenosine A1 receptor	B	4.32	pKi	48000	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb	-	-	4.32	pKi	48000	nM	Ki	Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells 90 mins by liquid scintillation counting analysis	B	6.77	pKi	169	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membrane after 90 mins by liquid scintillation counting analysis	B	7.15	pKi	70.8	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745]
ChEMBL	In vitro prolonging of the stimulus-QRS interval in guinea pig heart.	B	5.45	pEC50	3548.13	nM	EC50	J Med Chem (1992) 35: 4557-4561 [PMID:1469687]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Binding affinity to A2A adenosine receptor	B	6.57	pKi	270	nM	Ki	J Med Chem (2012) 55: 538-552 [PMID:22104008]
ChEMBL	Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK cells	B	6.57	pKi	270	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
ChEMBL	Binding affinity to human recombinant adenosine receptor A2a	B	6.57	pKi	270	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Binding affinity to human adenosine A2A receptor	B	6.57	pKi	270	nM	Ki	J Med Chem (2015) 58: 3253-3267 [PMID:25780876]
GtoPdb	-	-	6.57	pKi	270	nM	Ki	Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376]
ChEMBL	Displacement of [3H]CGS21680 from human recombinant adenosine A2A receptor expressed in HEK cells after 60 mins by liquid scintillation counting	B	7.09	pKi	81	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Displacement of [3H]CGS21680 from adenosine A2A receptor in rat brain striatal membrane after 60 mins by liquid scintillation counting analysis	B	7.59	pKi	25.5	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	3.37	pKi	430000	nM	Ki	Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376]
ChEMBL	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells after 75 mins by liquid scintillation counting analysis	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
ChEMBL	Agonist activity at human recombinant adenosine receptor A2b by cAMP assay	F	4	pEC50	>100000	nM	EC50	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
GtoPdb	-	-	6.04	pKi	903	nM	Ki	Nat Rev Drug Discov (2006) 5: 247-64 [PMID:16518376]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A3 receptor	B	6.04	pKi	903	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]
ChEMBL	Binding affinity to human recombinant adenosine A3 receptor	B	6.04	pKi	903	nM	Ki	J Med Chem (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells after 180 mins by liquid scintillation counting analysis	B	7.28	pKi	52.6	nM	Ki	Bioorg Med Chem (2013) 21: 436-447 [PMID:23245803]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]