dorzolamide [Ligand Id: 6810] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL218490 (Dorzant, Dorzolamide, Dorzolamide, trans-(-)-, MK-507, Trusopt) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] | ||||||||
| ChEMBL | Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 6.56 | pKi | 275 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] | ||||||||
| ChEMBL | Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay | B | 7.74 | pKi | 18.1 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay | B | 7.74 | pKi | 18.1 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after 24 hrs by dual luciferase reporter gene assay | B | 7.19 | pIC50 | 65 | nM | IC50 | J Med Chem (2020) 63: 12642-12665 [PMID:33095584] |
| Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] | ||||||||
| ChEMBL | Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting method | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (2020) 63: 12642-12665 [PMID:33095584] |
| Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] | ||||||||
| ChEMBL | Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay | B | 6.55 | pKi | 280 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] | ||||||||
| ChEMBL | Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 8.1 | pKi | 8 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] | ||||||||
| ChEMBL | Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay | B | 7 | pKi | 99 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881] | ||||||||
| ChEMBL | Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila | B | 5.77 | pKi | 1710 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila | B | 6.39 | pKi | 410 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] | ||||||||
| ChEMBL | Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 6.95 | pKi | 113 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] | ||||||||
| ChEMBL | Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum | B | 4.51 | pKi | 30700 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] | ||||||||
| ChEMBL | Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay | B | 6.05 | pKi | 887 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 6.05 | pKi | 887 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] | ||||||||
| ChEMBL | Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay | B | 5.18 | pKi | 6635 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020] |
| Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615] | ||||||||
| ChEMBL | Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay | B | 6.96 | pKi | 110 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] | ||||||||
| ChEMBL | Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay | B | 5.36 | pKi | 4360 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of Helicobacter pylori recombinant CA | B | 5.37 | pKi | 4310 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] | ||||||||
| ChEMBL | Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay | B | 7.21 | pKi | 61 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] | ||||||||
| ChEMBL | Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 5.08 | pKi | 8347 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] | ||||||||
| ChEMBL | Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay | B | 8.15 | pKi | 7 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase I at 0.09 uM | B | 1.3 | pKi | 50000000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (hCAI) | B | 1.3 | pKi | 50000000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| GtoPdb | - | - | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (hCA I) | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846] |
| ChEMBL | Binding affinity against human carbonic anhydrase I (hCA I) | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1787-1791 [PMID:11425561] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase I | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| ChEMBL | Inhibition of human carbonic anhydrase I | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332] |
| ChEMBL | Inhibition constant determined against human cloned carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase I (CA1) | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2000) 43: 4542-4551 [PMID:11087579] |
| ChEMBL | Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method. | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method. | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibition of human cloned Carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 673-676 [PMID:10762051] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560] |
| ChEMBL | In vitro inhibitory activity against human carbonic anhydrase I (hCAI) | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2004) 47: 2796-2804 [PMID:15139757] |
| ChEMBL | Inhibition of human carbonic anhydrase I (CAI) | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form). | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibitory activity against Human carbonic anhydrase I | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase I (CA1) | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853] |
| ChEMBL | Inhibitory activity against cytosolic human carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956] |
| ChEMBL | Ki value against human carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Ki value against human carbonic anhydrase I (hCA I) | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory activity against human Carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2004) 47: 5224-5229 [PMID:15456265] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibitory activity against cloned human CA1 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA1 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human cloned CA1 by stopped-flow CO2 hydration method | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase I | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2000) 43: 4884-4892 [PMID:11123998] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| ChEMBL | Inhibition of full length human CA 1 | B | 4.3 | pKi | 50000 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I (hCA I) by using esterase assay method | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human full length cytosolic carbonic anhydrase 1 after 15 mins by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 by CO2 hydrase stopped flow assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6565-6570 [PMID:19854054] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human CA1 by CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-1 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.3 | pKi | >50000 | nM | Ki | Bioorg Med Chem (2015) 23: 6223-6227 [PMID:26319622] |
| ChEMBL | Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 4.3 | pKi | 50000 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of esterase activity of carbonic anhydrase 1 in human erythrocytes using PNF as substrate by spectrophotometer analysis | B | 5.77 | pKi | 1686 | nM | Ki | Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay | B | 6.3 | pKi | 500 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human cloned CA1 by CO2 hydration method | B | 6.3 | pKi | 500 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase I was determined | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Binding affinity to human carbonic anhydrase 2 incubated for 1 hr using labeled BODIPY558/568-acetazolamide as tracer by fluorescence polarization tight binding assay | B | 10.37 | pKd | 0.04 | nM | Kd | J Med Chem (2015) 58: 2821-2833 [PMID:25728019] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II at 0.01 uM | B | 5.05 | pKi | 9000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysis | B | 7.6 | pKi | 25 | nM | Ki | Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269] |
| ChEMBL | Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.04 | pKi | 9.1 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| ChEMBL | Binding affinity against human carbonic anhydrase II (hCA -II) | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1787-1791 [PMID:11425561] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| ChEMBL | Inhibition of human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 225-229 [PMID:14684332] |
| ChEMBL | Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH) | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase II (CA2) | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2000) 43: 4542-4551 [PMID:11087579] |
| ChEMBL | Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method. | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903] |
| ChEMBL | Inhibition of human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibition of human cloned Carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 673-676 [PMID:10762051] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560] |
| ChEMBL | In vitro inhibitory activity against human carbonic anhydrase II (hCAII) | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2004) 47: 2796-2804 [PMID:15139757] |
| ChEMBL | Inhibition of human carbonic anhydrase II (hCA II) | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2000) 43: 4884-4892 [PMID:11123998] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| ChEMBL | Inhibition of full length human CA 2 | B | 8.05 | pKi | 9 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2020) 63: 3317-3326 [PMID:32031797] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibitory activity against Human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Inhibitory activity against human recombinant carbonic anhydrase II (CA2) | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853] |
| ChEMBL | Inhibitory activity against cytosolic human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956] |
| ChEMBL | Ki value against human carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Ki value against human carbonic anhydrase II (hCA II) | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II (hCAII) | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory activity against human Carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2004) 47: 5224-5229 [PMID:15456265] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase II | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibitory activity against human recombinant cytosolic CA2 | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibitory activity against cloned human CA2 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2006) 49: 2117-2126 [PMID:16539401] |
| ChEMBL | Inhibition of human recombinant CA2 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077] |
| ChEMBL | Inhibition of human cloned CA2 by stopped-flow CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human cloned CA2 by CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2009) 52: 2226-2232 [PMID:19317447] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577] |
| ChEMBL | Inhibition of human full length cytosolic carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6565-6570 [PMID:19854054] |
| ChEMBL | Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
| ChEMBL | Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5 | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369] |
| ChEMBL | Inhibition of human CA2 by CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2012) 55: 3513-3520 [PMID:22424239] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (2013) 56: 1761-1771 [PMID:23391336] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813] |
| ChEMBL | Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-2 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2015) 23: 6223-6227 [PMID:26319622] |
| ChEMBL | Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758] |
| ChEMBL | Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216] |
| ChEMBL | Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II) | B | 8.26 | pKi | 5.5 | nM | Ki | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II) | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Dissociation constant against Carbonic anhydrase II was reported in experiment 1 | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (2002) 45: 3588-3602 [PMID:12166932] |
| ChEMBL | Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II) | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II) | B | 9.43 | pKi | 0.37 | nM | Ki | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II) | B | 9.55 | pKi | 0.28 | nM | Ki | J Med Chem (1994) 37: 240-247 [PMID:8295211] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay | B | 9.7 | pKi | 0.2 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 939-943 [PMID:23317571] |
| ChEMBL | Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assay | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2015) 58: 2821-2833 [PMID:25728019] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase II was determined | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| ChEMBL | Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II) | B | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Inhibition of carbonic anhydrase 2 | B | 8.7 | pIC50 | <2 | nM | IC50 | Bioorg Med Chem (2010) 18: 3307-3319 [PMID:20363633] |
| ChEMBL | Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II) | B | 8.96 | pIC50 | 1.1 | nM | IC50 | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II) | B | 9.64 | pIC50 | 0.23 | nM | IC50 | J Med Chem (1994) 37: 1035-1054 [PMID:8164249] |
| ChEMBL | Inhibitory activity against carbonic anhydrase II | B | 9.74 | pIC50 | 0.18 | nM | IC50 | J Med Chem (2002) 45: 3588-3602 [PMID:12166932] |
| ChEMBL | Tested for ability to inhibit human erythrocyte carbonic-anhydrase-II- (HCA II) catalyzed carbon dioxide hydration | B | 9.74 | pIC50 | 0.18 | nM | IC50 | J Med Chem (1994) 37: 240-247 [PMID:8295211] |
| Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase 3 | B | 5.1 | pKi | 8000 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IV (hCAIV) | B | 5.07 | pKi | 8530 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibition of human cloned CA4 by stopped-flow CO2 hydration method | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 4 | B | 5.07 | pKi | 8500 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay | B | 5.07 | pKi | 8500 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length membrane-bound carbonic anhydrase 4 after 15 mins by stopped-flow CO2 hydration assay | B | 5.07 | pKi | 8500 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human CA4 by CO2 hydration assay | B | 5.07 | pKi | 8500 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597] |
| ChEMBL | Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assay | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6565-6570 [PMID:19854054] |
| ChEMBL | Inhibition of cloned isozyme, human carbonic anhydrase IV | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 575-582 [PMID:11229775] |
| ChEMBL | Inhibition of carbonic anhydrase 4 | B | 7.37 | pIC50 | 43 | nM | IC50 | Bioorg Med Chem (2010) 18: 3307-3319 [PMID:20363633] |
| Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323] | ||||||||
| ChEMBL | Inhibition of bovine Carbonic anhydrase IV determined by esterase method | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 673-676 [PMID:10762051] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes | B | 7.35 | pKi | 45 | nM | Ki | J Med Chem (1999) 42: 3690-3700 [PMID:10479300] |
| ChEMBL | Inhibition of bovine carbonic anhydrase IV from bovine lung microsomes | B | 7.35 | pKi | 45 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 1117-1120 [PMID:10843231] |
| ChEMBL | Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV). | B | 7.35 | pKi | 45 | nM | Ki | J Med Chem (1999) 42: 2641-2650 [PMID:10411484] |
| ChEMBL | Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2000) 43: 4542-4551 [PMID:11087579] |
| ChEMBL | Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2004) 47: 1272-1279 [PMID:14971907] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method. | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560] |
| ChEMBL | In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV) | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2004) 47: 2796-2804 [PMID:15139757] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2002) 45: 1466-1476 [PMID:11906288] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV (bCAIV) | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2000) 43: 4884-4892 [PMID:11123998] |
| ChEMBL | Inhibitory activity against CA4 isolated from bovine lung microsomes | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846] |
| ChEMBL | Compound was evaluated for binding affinity against bovine Carbonic anhydrase IV | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1787-1791 [PMID:11425561] |
| ChEMBL | Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes | B | 7.37 | pKi | 43 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibitory activity against bovine carbonic anhydrase IV was determined | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] | ||||||||
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX at 0.09 uM | B | 4.28 | pKi | 52000 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717] |
| ChEMBL | Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX. | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691] |
| ChEMBL | Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2003) 46: 2187-2196 [PMID:12747790] |
| ChEMBL | Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method. | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039] |
| ChEMBL | Inhibitory activity against Carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2005) 48: 2121-2125 [PMID:15771455] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816] |
| ChEMBL | Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21 | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21 | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239] |
| ChEMBL | Inhibitory constant against human Carbonic anhydrase IX | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091] |
| ChEMBL | Inhibitory activity against cloned human CA9 | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146] |
| ChEMBL | Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of catalytic domain of human recombinant CA IX | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human cloned catalytic domain CA9 by CO2 hydration method | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760] |
| ChEMBL | Inhibition of human carbonic anhydrase 9 | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human CA9 catalytic domain by CO2 hydration method | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2008) 51: 1945-1953 [PMID:18307288] |
| ChEMBL | Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| ChEMBL | Inhibition of human membrane-bound carbonic anhydrase 9 catalytic domain after 15 mins by stopped-flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173] |
| ChEMBL | Inhibition of human recombinant CA9 catalytic domain by CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-9 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem (2015) 23: 6223-6227 [PMID:26319622] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method | B | 7.28 | pKi | 52 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Inhibition of human CA 9 catalytic domain | B | 7.28 | pKi | 52 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibitory activity against human carbonic anhydrase IX was determined | B | 7.28 | pIC50 | 52 | nM | IC50 | J Med Chem (2004) 47: 550-557 [PMID:14736236] |
| carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VA | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human cloned CA5A by stopped-flow CO2 hydration method | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 5A | B | 7.38 | pKi | 42 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay | B | 7.38 | pKi | 42 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length mitochondrial carbonic anhydrase 5A after 15 mins by stopped-flow CO2 hydration assay | B | 7.38 | pKi | 42 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] | ||||||||
| ChEMBL | Inhibitory activity against human recombinant mitochondrial isozyme CA VB | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2005) 48: 7860-7866 [PMID:16302824] |
| ChEMBL | Inhibition of human cloned CA5B by stopped-flow CO2 hydration method | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 5B | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay | B | 7.48 | pKi | 33 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length mitochondrial carbonic anhydrase 5B after 15 mins by stopped-flow CO2 hydration assay | B | 7.48 | pKi | 33 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.98 | pKi | 10.4 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| ChEMBL | Inhibition of human carbonic anhydrase 6 | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of full length human recombinant CA VI | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2007) 50: 381-388 [PMID:17228881] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay | B | 8 | pKi | 10 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801] |
| ChEMBL | Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2009) 52: 646-654 [PMID:19193158] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Ki value against human carbonic anhydrase VII | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Inhibition of human cloned CA7 by stopped-flow CO2 hydration method | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human carbonic anhydrase 7 | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length cytosolic carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389] |
| ChEMBL | Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human carbonic anhydrase7 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| GtoPdb | - | - | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human CA 12 catalytic domain | B | 8.46 | pKi | 3.5 | nM | Ki | Eur J Med Chem (2019) 168: 301-314 [PMID:30826507] |
| ChEMBL | Inhibitory constant against catalytic domain of human carbonic anhydrase XII | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Ki value against human carbonic anhydrase XII (hCA XII) | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894] |
| ChEMBL | Inhibitory activity against cloned human CA12 | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 437-442 [PMID:16290146] |
| ChEMBL | Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant CA12 by CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501] |
| ChEMBL | Inhibition of human carbonic anhydrase 12 | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 2273-2276 [PMID:19286378] |
| ChEMBL | Inhibition of human membrane-bound carbonic anhydrase 12 catalytic domain after 15 mins by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2009) 17: 7093-7099 [PMID:19773173] |
| ChEMBL | Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 3216-3221 [PMID:21549597] |
| ChEMBL | Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175] |
| ChEMBL | Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| ChEMBL | Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184] |
| ChEMBL | Inhibitory activity against catalytic domain of human carbonic anhydrase XII | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853] |
| ChEMBL | Inhibition of human recombinant carbonic anhydrase-12 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay | B | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem (2015) 23: 6223-6227 [PMID:26319622] |
| ChEMBL | Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay | B | 8.46 | pKi | 3.5 | nM | Ki | J Med Chem (2018) 61: 5380-5394 [PMID:29851481] |
| GtoPdb | - | - | 8.46 | pKi | 3.5 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894] |
| ChEMBL | Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] | ||||||||
| ChEMBL | Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] | ||||||||
| ChEMBL | Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3757-3762 [PMID:15203157] |
| ChEMBL | Ki value against murine carbonic anhydrase XIII | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895] |
| ChEMBL | Inhibition of murine CA13 by stopped-flow CO2 hydration method | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of mouse carbonic anhydrase 13 | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay | B | 7.74 | pKi | 18 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of mouse full length cytosolic carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay | B | 7.74 | pKi | 18 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] | ||||||||
| ChEMBL | Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848] |
| ChEMBL | Inhibition of human cloned CA14 by stopped-flow CO2 hydration method | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2006) 49: 7024-7031 [PMID:17125255] |
| ChEMBL | Inhibition of human recombinant CA14 by CO2 hydration assay | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501] |
| ChEMBL | Inhibition of human carbonic anhydrase 14 | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500] |
| ChEMBL | Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629] |
| ChEMBL | Inhibition of human full length membrane-bound carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (2009) 52: 5990-5998 [PMID:19731956] |
| ChEMBL | Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assay | B | 7.57 | pKi | 27 | nM | Ki | Bioorg Med Chem (2013) 21: 7210-7215 [PMID:24090602] |
| GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 1149-54 [PMID:15686931] |
| Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] | ||||||||
| ChEMBL | Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay | B | 7.3 | pKi | 49.6 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394] |
| PROBABLE TRANSMEMBRANE CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5767] [UniProtKB: P96878] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay | B | 6.86 | pKi | 137 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
| Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] | ||||||||
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay | B | 6.13 | pKi | 744 | nM | Ki | J Med Chem (2009) 52: 3116-3120 [PMID:19338333] |
| ChEMBL | Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay | B | 6.13 | pKi | 744 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 4929-4932 [PMID:19651511] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
