DFGYVAE [Ligand Id: 3023] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1163804
  • hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
GtoPdb In vitro inhibition of HMG-CoA reductase - 7.29 pKi 51 nM Ki Bioorg Med Chem (2010) 18: 4300-9 [PMID:20494585]
ChEMBL Competitive inhibition of HMG-CoA reductase by Dixon plot analysis B 7.29 pKi 51 nM Ki Bioorg Med Chem (2010) 18: 4300-4309 [PMID:20494585]
ChEMBL Inhibition of HMG-CoA reductase by spectrophotometry B 6.8 pIC50 160 nM IC50 Bioorg Med Chem (2010) 18: 4300-4309 [PMID:20494585]
GtoPdb Inhibition of HMG-CoA reductase - 6.8 pIC50 160 nM IC50 Bioorg Med Chem (2010) 18: 4300-9 [PMID:20494585]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]