ethosuximide

Ligand id: 7182

Name: ethosuximide

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: ethosuximide

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 49.66
Molecular weight 141.08
XLogP 0.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1960))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
3-ethyl-5-hydroxy-3-methyl-3,4-dihydro-2H-pyrrol-2-one
International Nonproprietary Names
INN number INN
1077 ethosuximide
Synonyms
CI-366 | CN-10395 | PM-671 | Zarontin®
Comments
Ethosuximide is a succinimide anticonvulsant. It is often preferred over valproic acid as it does not produce the same hepatotoxicity.
Database Links
CAS Registry No. 77-67-8
ChEMBL Ligand CHEMBL696
DrugBank Ligand DB00593
GtoPdb PubChem SID 178103757
PubChem CID 3291
Search Google for chemical match using the InChIKey HAPOVYFOVVWLRS-UHFFFAOYSA-N
Search Google for chemicals with the same backbone HAPOVYFOVVWLRS
Search PubMed clinical trials ethosuximide
Search PubMed titles ethosuximide
Search PubMed titles/abstracts ethosuximide
Search UniChem for chemical match using the InChIKey HAPOVYFOVVWLRS-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone HAPOVYFOVVWLRS
Wikipedia Ethosuximide