ethosuximide   Click here for help

GtoPdb Ligand ID: 7182

Synonyms: CI-366 | CN-10395 | PM-671 | Zarontin®
Approved drug
ethosuximide is an approved drug (FDA (1960))
Compound class: Synthetic organic
Comment: Ethosuximide is a succinimide anticonvulsant. It is often preferred over valproic acid as it does not produce the same hepatotoxicity.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 49.66
Molecular weight 141.08
XLogP 0.75
No. Lipinski's rules broken 0
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Canonical SMILES CC1(CC)CC(=NC1=O)O
Isomeric SMILES CC1(CC)CC(=NC1=O)O
InChI InChI=1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
No information available.
Summary of Clinical Use Click here for help
Ethosuximide is used to treat absence type epileptic and myoclonic seizures.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Ethosuximide blocks activity of transient (T-type) voltage gated calcium channels. CACNA1E, CACNA1H and CACNA1I alpha subunits are detailed in this database, in the Voltage-gated calcium channels section. See the DrugBank link for further details explaining the predicted molecular mechanism of action of this drug.
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