arachidonyl-2-chloroethylamide [Ligand Id: 738] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL151167 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CB1 receptor/Cannabinoid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells | B | 8.28 | pKi | 5.3 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6505-6510 [PMID:17942307] |
| CB1 receptor/Cannabinoid receptor 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3037] [GtoPdb: 56] [UniProtKB: P47746] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from CB1 receptor in DBA/J2 mouse brain | B | 8.41 | pKi | 3.9 | nM | Ki | J Med Chem (2006) 49: 5947-5957 [PMID:17004710] |
| CB1 receptor/Cannabinoid receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3571] [GtoPdb: 56] [UniProtKB: P20272] | ||||||||
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the absence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 5.47 | pKi | 3400 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in the presence of phenylmethanesulfonylfluoride (PMSF) using 0.8 nM [3H]CP-55940 as radioligand | B | 8.28 | pKi | 5.29 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | Displacement of [3H]-CP55940 from CB1 receptor of rat cerebellar membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 8.85 | pKi | 1.4 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| GtoPdb | - | - | 8.9 | pKi | - | - | - | J Pharmacol Exp Ther (1999) 289: 1427-33 [PMID:10336536] |
| ChEMBL | Displacement of [35S]GTP-gamma-S from rat cerebellar CB1 receptor | F | 6.5 | pEC50 | 316.23 | nM | EC50 | J Med Chem (2006) 49: 554-566 [PMID:16420041] |
| CB2 receptor/Cannabinoid receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] | ||||||||
| ChEMBL | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells | B | 7.02 | pKi | 95 | nM | Ki | Bioorg Med Chem Lett (2007) 17: 6505-6510 [PMID:17942307] |
| CB2 receptor/Cannabinoid receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5373] [GtoPdb: 57] [UniProtKB: P47936] | ||||||||
| ChEMBL | Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes using 0.8 nM [3H]CP-55940 as radioligand | B | 6.71 | pKi | 195 | nM | Ki | J Med Chem (1998) 41: 5353-5361 [PMID:9876105] |
| ChEMBL | Displacement of [3H]CP-55940 from CB2 receptor in DBA/J2 mouse spleen | B | 6.92 | pKi | 120.8 | nM | Ki | J Med Chem (2006) 49: 5947-5957 [PMID:17004710] |
| CB2 receptor/Cannabinoid receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2470] [GtoPdb: 57] [UniProtKB: Q9QZN9] | ||||||||
| ChEMBL | Displacement of [3H]-CP55940 from CB2 receptor of rat spleen membranes by liquid scintillation counting in presence of serine protease inhibitor PMSF | B | 5.7 | pKi | >2000 | nM | Ki | J Med Chem (2013) 56: 8224-8256 [PMID:23865723] |
| Fatty acid amide hydrolase/Fatty-acid amide hydrolase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Inhibition of FAAH | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
