daptomycin [Ligand Id: 10904] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL387675 (LY-146032, LY 146032, Daptomycin, Cubicin, Cubicin rf, LY-164032)
  • GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
  • This target only has 0 pki data point
  • 0
1 CHEMBL387675_lig_chart_1 GroEL/GroES Escherichia coli
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2 CHEMBL387675_lig_chart_2 HSP60/HSP10 Human
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  • Thiosulfate sulfurtransferase in Human [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762]
  • This target only has 0 pki data point
  • 0
3 CHEMBL387675_lig_chart_3 Thiosulfate sulfurtransferase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured MDH refolding after 20 to 40 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
ChEMBL Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding after 45 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809P61604]
ChEMBL Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding after 40 to 60 mins by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]
Thiosulfate sulfurtransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295835] [UniProtKB: Q16762]
ChEMBL Inhibition of refolded rhodanese (unknown origin) preincubated with Escherichia coli GroEL/GroES for 60 mins in absence of compound followed by compound addition by spectrometric analysis B 4 pIC50 >100000 nM IC50 J Med Chem (2018) 61: 10651-10664 [PMID:30392371]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]