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Synonyms: Cubicin® | LY-146032 | LY146032
daptomycin is an approved drug (FDA (2003), EMA (2006))
Compound class:
Synthetic organic
Comment: Daptomycin is a semi-synthetic cyclic lipopeptide antibacterial with broad-spectrum activity against Gram-positive bacteria. It is a bacterial metabolite that was isolated from Streptomyces roseosporus. Daptomycin rapidly depolarizes the bacterial cell membrane which disrupts DNA, RNA and protein synthesis and results in cell death.
This antibacterial was removed from the World Health Organization's List of Essential Medicines in 2019. |
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes. EU EMA (2006) | US FDA (2003) |
International Nonproprietary Names ![]() |
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INN number | INN |
6127 | daptomycin |
Synonyms ![]() |
Cubicin® | LY-146032 | LY146032 |
Database Links ![]() |
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Specialist databases | |
Antibiotic DB
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Daptomycin (Cubicin) |
Other databases | |
CAS Registry No. | 103060-53-3 (source: WHO INN record) |
ChEMBL Ligand | CHEMBL387675 |
GtoPdb PubChem SID | 405560345 |
PubChem CID | 16134395 |
Search Google for chemical match using the InChIKey | DOAKLVKFURWEDJ-RWDRXURGSA-N |
Search Google for chemicals with the same backbone | DOAKLVKFURWEDJ |
Search PubMed clinical trials | daptomycin |
Search PubMed titles | daptomycin |
Search PubMed titles/abstracts | daptomycin |
UniChem Compound Search for chemical match using the InChIKey | DOAKLVKFURWEDJ-RWDRXURGSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | DOAKLVKFURWEDJ-RWDRXURGSA-N |