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Synonyms: Cubicin® | LY-146032 | LY146032
daptomycin is an approved drug (FDA (2003), EMA (2006))
Compound class: Synthetic organic
Comment: Daptomycin is a semi-synthetic cyclic lipopeptide antibiotic with broad-spectrum activity against Gram-positive bacteria. It is a bacterial metabolite that was isolated from Streptomyces roseosporus. Daptomycin rapidly depolarizes the bacterial cell membrane which disrupts DNA, RNA and protein synthesis and results in cell death.
IThis antibiotic was removed from the World Health Organization's List of Essential Medicines in 2019.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖