cantharidin [Ligand Id: 13081] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL48449 (Cantaridina, Cantharides camphor, Cantharidin, Cantharidine, Cantharidinum, NSC-61805) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite LDH activity at 100 uM after 72 hrs by malstat reagent method | F | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6688-6695 [PMID:20888768] |
| ChEMBL | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as inhibition of parasite LDH activity after 72 hrs by malstat reagent method | F | 5.05 | pIC50 | 9000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6688-6695 [PMID:20888768] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.5 | pIC50 | 3162.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| Protein phosphatase 2C beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2845] [UniProtKB: O75688] | ||||||||
| ChEMBL | Inhibitory activity against recombinant Protein phosphatase 1 | B | 5.75 | pIC50 | 1780 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1687-1690 [PMID:10937725] |
| ChEMBL | Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscle | B | 6.37 | pIC50 | 430 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1969-1973 [PMID:15050639] |
| protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] | ||||||||
| ChEMBL | Inhibitory concentration against protein phosphatase 1 was determined | B | 5.44 | pIC50 | 3600 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2941-2946 [PMID:11677131] |
| Serine-threonine protein phosphatase 2A regulatory subunit in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2669] [UniProtKB: Q8AWE3] | ||||||||
| ChEMBL | Concentration required to inhibit the action of protein phosphatase 2A | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-393 [PMID:11814804] |
| ChEMBL | Inhibitory concentration against protein phosphatase 2A was determined | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 2941-2946 [PMID:11677131] |
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 2A by anhydride modified Cantharidin analogues | B | 6.59 | pIC50 | 260 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| ChEMBL | Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A | B | 6.59 | pIC50 | 260 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1687-1690 [PMID:10937725] |
| ChEMBL | Exogenous inhibition concentration of Serine/threonine protein phosphatase 2A (PP2A) | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| Serine/threonine protein phosphatase PP1-gamma catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4438] [UniProtKB: P36873] | ||||||||
| ChEMBL | Inhibition of Serine/threonine protein phosphatase 1 by anhydride modified Cantharidin analogues | B | 5.75 | pIC50 | 1780 | nM | IC50 | J Med Chem (2002) 45: 1151-1175 [PMID:11881984] |
| protein phosphatase 2 catalytic subunit alpha in Human [GtoPdb: 3263] [UniProtKB: P67775] | ||||||||
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6688-95 [PMID:20888768] |
| protein phosphatase 1 catalytic subunit alpha in Human [GtoPdb: 3264] [UniProtKB: P62136] | ||||||||
| GtoPdb | - | - | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 391-3 [PMID:11814804] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
