arteflene [Ligand Id: 10397] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL380230 (Arteflene, RO 42-1611, RO-42-1611, RO-421611) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 7.12 | pIC50 | 76 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2991-2995 [PMID:16527481] |
| ChEMBL | In vitro antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF 54 | F | 7.15 | pIC50 | 71 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 903-908 [PMID:9871509] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth | F | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem (2015) 23: 5120-5130 [PMID:25913864] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
