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ChEMBL ligand: CHEMBL360055 (Gallamine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | Inhibition of Torpedo californica AChE | B | 4.82 | pKi | 15000 | nM | Ki | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human AChE | B | 4.43 | pKi | 37000 | nM | Ki | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
ChEMBL | Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 | B | 5.07 | pKi | 8511.38 | nM | Ki | J Med Chem (2012) 55: 2125-2143 [PMID:22329602] |
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199] | ||||||||
ChEMBL | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | B | 6.88 | pEC50 | 131.83 | nM | EC50 | J Med Chem (2007) 50: 5685-5695 [PMID:17944454] |
ChEMBL | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | B | 6.89 | pEC50 | 130 | nM | EC50 | J Med Chem (2007) 50: 5685-5695 [PMID:17944454] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 6.3 | pKd | - | - | - |
Mol Pharmacol (1995) 48: 362-78 [PMID:7651370]; Br J Pharmacol (1976) 58: 323-31 [PMID:990587] |
GtoPdb | - | - | 7.6 | pKi | - | - | - |
J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]; Mol Pharmacol (2003) 64: 180-90 [PMID:12815174]; Mol Pharmacol (2018) 94: 1298-1309 [PMID:30213802] |
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980] | ||||||||
GtoPdb | - | - | 5.6 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708] | ||||||||
GtoPdb | - | - | 6 | pIC50 | ~1000 | nM | IC50 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]