gallamine [Ligand Id: 356] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL360055 (Gallamine)
  • Acetylcholinesterase in Torpedo californica [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • 4.43
1 CHEMBL360055_lig_chart_1 Acetylcholinesterase Torpedo californicaHuman
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  • M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
  • This target only has 1 pki data point
  • 5.07
2 CHEMBL360055_lig_chart_2 Muscarinic acetylcholine receptor M1 Human
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  • Muscarinic acetylcholine receptor M2 in Pig [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
  • This target only has 0 pki data point
  • 0
3 CHEMBL360055_lig_chart_3 Muscarinic acetylcholine receptor M2 Pig
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  • M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
  • M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
  • 5.6
4 CHEMBL360055_lig_chart_4 M2 receptor HumanRat
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  • nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
  • This target only has 0 pki data point
  • 0
5 CHEMBL360055_lig_chart_5 nicotinic acetylcholine receptor α1 subunit Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
ChEMBL Inhibition of Torpedo californica AChE B 4.82 pKi 15000 nM Ki J. Med. Chem. (2008) 51: 3154-3170 [PMID:18479118]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of human AChE B 4.43 pKi 37000 nM Ki J. Med. Chem. (2008) 51: 3154-3170 [PMID:18479118]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 B 5.07 pKi 8511.38 nM Ki J. Med. Chem. (2012) 55: 2125-2143 [PMID:22329602]
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
ChEMBL Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor B 6.88 pEC50 131.83 nM EC50 J. Med. Chem. (2007) 50: 5685-5695 [PMID:17944454]
ChEMBL Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor B 6.89 pEC50 130 nM EC50 J. Med. Chem. (2007) 50: 5685-5695 [PMID:17944454]
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172]
GtoPdb - - 6.3 pKd - - - Mol Pharmacol (1995) 48: 362-78 [PMID:7651370];
Br J Pharmacol (1976) 58: 323-31 [PMID:990587]
GtoPdb - - 7.6 pKi - - - J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790];
Mol Pharmacol (2003) 64: 180-90 [PMID:12815174];
Mol Pharmacol (2018) 94: 1298-1309 [PMID:30213802]
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980]
GtoPdb - - 5.6 pKi - - - J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
GtoPdb - - 6 pIC50 ~1000 nM IC50

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]