L742791 [Ligand Id: 3467] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL276257
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
  • This target only has 0 pki data point
1 CHEMBL276257_lig_chart_1 Beta-1 adrenergic receptor Human
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
  • This target only has 0 pki data point
2 CHEMBL276257_lig_chart_2 Beta-2 adrenergic receptor Human
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
  • This target only has 0 pki data point
3 CHEMBL276257_lig_chart_3 Beta-3 adrenergic receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Evaluated for its agonist activity and the binding affinity against human Beta-1 adrenergic receptor in membranes from chinese hamster ovary cell B 6.77 pIC50 170 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Tested for binding affinity against cloned human beta-1 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand B 6.77 pIC50 170 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 1101-1106 [PMID:9871716]
ChEMBL Compound was tested for agonist activity against cloned human beta-1 adrenergic receptor F 6.49 pEC50 320 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 1101-1106 [PMID:9871716]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Evaluated for its agonist activity and the binding affinity against human Beta-2 adrenergic receptor in membranes from chinese hamster ovary cell B 6.92 pIC50 120 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Binding affinity against cloned human beta-2 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand B 6.92 pIC50 120 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 1101-1106 [PMID:9871716]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Evaluated for its agonist activity against human Beta-3 adrenergic receptor F 8.8 pEC50 1.6 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Agonist activity against cloned human beta-3 adrenergic receptor F 8.8 pEC50 1.6 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 1101-1106 [PMID:9871716]
GtoPdb - - 8.8 pEC50 1.6 nM EC50 Bioorg. Med. Chem. Lett. (1998) 8: 2111-6 [PMID:9873496]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]