L742791 [Ligand Id: 3467] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL276257 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| ChEMBL | Evaluated for its agonist activity and the binding affinity against human Beta-1 adrenergic receptor in membranes from chinese hamster ovary cell | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Tested for binding affinity against cloned human beta-1 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| ChEMBL | Compound was tested for agonist activity against cloned human beta-1 adrenergic receptor | F | 6.49 | pEC50 | 320 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| ChEMBL | Evaluated for its agonist activity and the binding affinity against human Beta-2 adrenergic receptor in membranes from chinese hamster ovary cell | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Binding affinity against cloned human beta-2 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| ChEMBL | Evaluated for its agonist activity against human Beta-3 adrenergic receptor | F | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496] |
| ChEMBL | Agonist activity against cloned human beta-3 adrenergic receptor | F | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716] |
| GtoPdb | - | - | 8.8 | pEC50 | 1.6 | nM | EC50 | Bioorg Med Chem Lett (1998) 8: 2111-6 [PMID:9873496] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
