L742791 [Ligand Id: 3467] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL276257
  • β1-adrenoceptor/Beta-1 adrenergic receptor in Human [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
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  • β2-adrenoceptor/Beta-2 adrenergic receptor in Human [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
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  • β3-adrenoceptor/Beta-3 adrenergic receptor in Human [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588]
ChEMBL Evaluated for its agonist activity and the binding affinity against human Beta-1 adrenergic receptor in membranes from chinese hamster ovary cell B 6.77 pIC50 170 nM IC50 Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Tested for binding affinity against cloned human beta-1 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand B 6.77 pIC50 170 nM IC50 Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716]
ChEMBL Compound was tested for agonist activity against cloned human beta-1 adrenergic receptor F 6.49 pEC50 320 nM EC50 Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716]
β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550]
ChEMBL Evaluated for its agonist activity and the binding affinity against human Beta-2 adrenergic receptor in membranes from chinese hamster ovary cell B 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Binding affinity against cloned human beta-2 adrenergic receptor from CHO cells using [125I]iodocyanopindolol as the radioligand B 6.92 pIC50 120 nM IC50 Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716]
β3-adrenoceptor/Beta-3 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL246] [GtoPdb: 30] [UniProtKB: P13945]
ChEMBL Evaluated for its agonist activity against human Beta-3 adrenergic receptor F 8.8 pEC50 1.6 nM EC50 Bioorg Med Chem Lett (1998) 8: 2111-2116 [PMID:9873496]
ChEMBL Agonist activity against cloned human beta-3 adrenergic receptor F 8.8 pEC50 1.6 nM EC50 Bioorg Med Chem Lett (1998) 8: 1101-1106 [PMID:9871716]
GtoPdb - - 8.8 pEC50 1.6 nM EC50 Bioorg Med Chem Lett (1998) 8: 2111-6 [PMID:9873496]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]