ChEMBL ligand: CHEMBL10372 (Alond, CP-73,850, CP-73850, Zopolrestat)
Aldehyde reductase in Human [ChEMBL: CHEMBL2246] [UniProtKB: P14550] There should be some charts here, you may need to enable JavaScript!
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] aldo-keto reductase family 1 member B/Aldose reductase in Rat [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943] There should be some charts here, you may need to enable JavaScript!
Aldose reductase-related protein 1 in Rat [ChEMBL: CHEMBL3421523] [UniProtKB: Q5RJP0] There should be some charts here, you may need to enable JavaScript!
Glyoxalase I in Human [ChEMBL: CHEMBL2424] [UniProtKB: Q04760] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldehyde reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2246] [UniProtKB: P14550]
ChEMBL	In vitro inhibition of recombinant human aldehyde reductase	B	4.41	pIC50	38600	nM	IC50	J Med Chem (2005) 48: 3141-3152 [PMID:15857120]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldehyde reductase expressed in Escherichia coli BL21(DE3) mediated D-glucuronate reduction	B	5.57	pIC50	2700	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of recombinant AKR1B10 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assay	B	5.63	pIC50	2360	nM	IC50	J Med Chem (2012) 55: 2311-2323 [PMID:22263837]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyridine-3-aldehyde reduction	B	6.21	pIC50	620	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Compound was tested for the rate of reduction of glyceraldehyde by human placental aldose reductase.	B	7.72	pKi	19	nM	Ki	J Med Chem (1991) 34: 108-122 [PMID:1899452]
GtoPdb	In vitro inhibition of recombinant human aldehyde reductase	-	4.41	pIC50	38600	nM	IC50	J Med Chem (2005) 48: 3141-52 [PMID:15857120]
ChEMBL	Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.	B	7.09	pIC50	81	nM	IC50	J Med Chem (1991) 34: 108-122 [PMID:1899452]
ChEMBL	Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reduction	B	7.22	pIC50	60	nM	IC50	Bioorg Med Chem (2010) 18: 2485-2490 [PMID:20304656]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 1M DMSO followed by compound addition by DMSO-perturbation assay	B	7.28	pIC50	52.9	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.7M DMSO followed by compound addition by DMSO-perturbation assay	B	7.37	pIC50	42.8	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibition of human recombinant AKR1B1 assessed as D,L-glyceraldehyde reduction pretreated with 0.3M DMSO followed by compound addition by DMSO-perturbation assay	B	7.42	pIC50	37.8	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126815-126815 [PMID:31744675]
ChEMBL	Inhibitory Activity against Human recombinant Aldose Reductase (wild type)	B	7.44	pIC50	36.4	nM	IC50	J Med Chem (2000) 43: 1062-1070 [PMID:10737739]
ChEMBL	Inhibition of human recombinant aldose reductase	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2008) 16: 3245-3254 [PMID:18165015]
ChEMBL	Inhibition of recombinant AKR1B1 assessed as NADP+ dependent reduction of DL-glyceraldehyde by fluorescence assay	B	7.57	pIC50	27	nM	IC50	J Med Chem (2012) 55: 2311-2323 [PMID:22263837]
ChEMBL	Inhibition of recombinant human AKR1B1 using D,L-glyceraldehyde as substrate	B	7.61	pIC50	24.8	nM	IC50	Bioorg Med Chem (2017) 25: 6353-6360 [PMID:29074349]
ChEMBL	In vitro inhibition of recombinant human aldose reductase expressed in Escherichia coli	B	8.05	pIC50	9	nM	IC50	J Med Chem (2005) 48: 3141-3152 [PMID:15857120]
ChEMBL	Inhibitory activity against aldose reductase isolated from human placenta	B	8.32	pIC50	4.8	nM	IC50	J Med Chem (1992) 35: 2155-2162 [PMID:1613743]
ChEMBL	In vitro inhibitroy concentration against Aldose reductase incubated at 24 degree C for 15 minutes in pH 7.0	B	8.4	pIC50	4	nM	IC50	J Med Chem (2005) 48: 6326-6339 [PMID:16190759]
ChEMBL	Inhibition of human recombinant Aldose reductase in streptozotocin diabetic rat	B	8.4	pIC50	4	nM	IC50	J Med Chem (2003) 46: 2283-2286 [PMID:12773033]
ChEMBL	Inhibition of human placental aldose reductase using glyceraldehyde as substrate in presence of NADPH	B	8.51	pIC50	3.1	nM	IC50	Eur J Med Chem (2017) 138: 1002-1033 [PMID:28759875]
ChEMBL	Inhibition of aldose reductase (aldo-keto reductase, AKR1B1) isolated from human placenta.	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (1991) 34: 108-122 [PMID:1899452]
ChEMBL	Inhibitory activity against aldose reductase enzyme	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (2003) 46: 417-426 [PMID:12540241]
ChEMBL	In vitro inhibitory activity against aldose reductase isolated from human placenta	B	8.51	pIC50	3.1	nM	IC50	J Med Chem (1992) 35: 457-465 [PMID:1738141]
ChEMBL	Inhibition of human placenta Aldose reductase	B	8.68	pIC50	2.1	nM	IC50	Bioorg Med Chem (2019) 27: 3979-3997 [PMID:31401008]
ChEMBL	Compound was tested for the inhibition of the human placental aldose reductase using the substrate as glyceraldehyde.	B	8.72	pIC50	1.9	nM	IC50	J Med Chem (1991) 34: 108-122 [PMID:1899452]
aldo-keto reductase family 1 member B/Aldose reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2622] [GtoPdb: 2768] [UniProtKB: P07943]
ChEMBL	Compound was tested for the inhibition of the rat lens aldose reductase using the substrate as glyceraldehyde	B	7.39	pIC50	41	nM	IC50	J Med Chem (1991) 34: 108-122 [PMID:1899452]
ChEMBL	Compound was tested for the inhibition of the rat lens aldose reductase using the substrate as glucose.	B	8	pIC50	10	nM	IC50	J Med Chem (1991) 34: 108-122 [PMID:1899452]
ChEMBL	Inhibition of Wistar rat lens aldose reductase 2	B	8.3	pIC50	5	nM	IC50	Bioorg Med Chem (2008) 16: 4908-4920 [PMID:18395454]
ChEMBL	Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometry	B	8.3	pIC50	5	nM	IC50	J Med Chem (2015) 58: 2649-2657 [PMID:25695864]
Aldose reductase-related protein 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3421523] [UniProtKB: Q5RJP0]
ChEMBL	Inhibition of Wistar rat kidney aldehyde reductase using D-glucuronate as substrate by spectrophotometry	B	7.31	pIC50	49	nM	IC50	J Med Chem (2015) 58: 2649-2657 [PMID:25695864]
Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760]
ChEMBL	Inhibition of human Glyoxalase-1 using GSH and MGO as substrate by Dixon plot analysis	B	8.92	pKi	1.2	nM	Ki	Bioorg Med Chem (2020) 28: 115243-115243 [PMID:31879183]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]