ABT-670 [Ligand Id: 8439] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL219182 (ABT-670)
  • D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
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  • D4 receptor/Dopamine D4 receptor in Human [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
  • D4 receptor/Dopamine D4 receptor in Rat [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membrane B 5 pKi >10000 nM Ki J. Med. Chem. (2006) 49: 7450-7465 [PMID:17149874]
ChEMBL Binding affinity to human D2S receptor B 5 pKi >10000 nM Ki J. Med. Chem. (2006) 49: 7450-7465 [PMID:17149874]
D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917]
GtoPdb - - 5.84 pKi 1445 nM Ki J Med Chem (2006) 49: 7450-65 [PMID:17149874]
ChEMBL Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membrane B 5.84 pKi 1445 nM Ki J. Med. Chem. (2006) 49: 7450-7465 [PMID:17149874]
ChEMBL Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR F 7.05 pEC50 89 nM EC50 J. Med. Chem. (2006) 49: 7450-7465 [PMID:17149874]
D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729]
ChEMBL Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR F 7.03 pEC50 93 nM EC50 J. Med. Chem. (2006) 49: 7450-7465 [PMID:17149874]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]