ABT-670 [Ligand Id: 8439] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL219182 (ABT-670) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
| ChEMBL | Displacement of [125I]7-OH-PIPAT from human D2L receptor expressed in HEK293 cell membrane | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Binding affinity to human D2S receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D4 receptor/Dopamine D4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL219] [GtoPdb: 217] [UniProtKB: P21917] | ||||||||
| GtoPdb | - | - | 5.84 | pKi | 1445 | nM | Ki | J Med Chem (2006) 49: 7450-65 [PMID:17149874] |
| ChEMBL | Displacement of [3H]A369508 from human D4 receptor expressed in HEK293 cell membrane | B | 5.84 | pKi | 1445 | nM | Ki | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| ChEMBL | Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 7.05 | pEC50 | 89 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
| D4 receptor/Dopamine D4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3361] [GtoPdb: 217] [UniProtKB: P30729] | ||||||||
| ChEMBL | Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR | F | 7.03 | pEC50 | 93 | nM | EC50 | J Med Chem (2006) 49: 7450-7465 [PMID:17149874] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
