ChEMBL ligand: CHEMBL204656 (Elvitegravir, GS-9137, JTK-303, Vitekta)
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/N6-adenosine-methyltransferase catalytic subunit in Human [ChEMBL: CHEMBL4739695] [GtoPdb: 3181] [UniProtKB: Q86U44] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL	Inhibition of HIV-1 integrase assessed as inhibition of 3'-processing activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in presence of Mg2+	B	5.09	pIC50	8100	nM	IC50	J Med Chem (2015) 58: 4610-4623 [PMID:25961960]
ChEMBL	Inhibition of HIV1 integrase 3'-processing activity by gel-based assays	B	5.09	pIC50	8100	nM	IC50	J Med Chem (2014) 57: 3223-3234 [PMID:24684270]
ChEMBL	Inhibition of HIV1 integrase strand transfer activity	B	5.14	pIC50	7200	nM	IC50	J Med Chem (2009) 52: 4869-4882 [PMID:19719237]
ChEMBL	Inhibition of HIV1 integrase 3'-processing activity	B	7.3	pIC50	50	nM	IC50	J Med Chem (2008) 51: 5125-5129 [PMID:18665580]
ChEMBL	Inhibition of HIV1 integrase 3'-end processing activity	B	7.3	pIC50	50	nM	IC50	J Med Chem (2008) 51: 7717-7730 [PMID:19053754]
ChEMBL	Inhibition of HIV-1 integrase assessed as inhibition of strand transfer activity using 32P-labeled DNA as substrate after 1 hr by gel-based assay in presence of Mg2+	B	7.55	pIC50	28	nM	IC50	J Med Chem (2015) 58: 4610-4623 [PMID:25961960]
ChEMBL	Inhibition of HIV1 integrase strand transfer activity by gel-based assay	B	7.55	pIC50	28	nM	IC50	J Med Chem (2014) 57: 3223-3234 [PMID:24684270]
ChEMBL	Inhibition of HIV1 integrase strand transfer	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2010) 18: 5510-5518 [PMID:20630765]
ChEMBL	Inhibition of Human immunodeficiency virus 1 integrase strand transfer activity	B	7.82	pIC50	15	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2861-2869 [PMID:18541726]
ChEMBL	Inhibition of HIV1 integrase strand transfer activity	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2891-2895 [PMID:18417342]
ChEMBL	Displacement of 20 nM [3H]GSK304649 from Human immunodeficiency virus 1 integrase by scintillation proximity assay	B	7.96	pIC50	11	nM	IC50	Antimicrob Agents Chemother (2008) 52: 901-908 [PMID:18160521]
ChEMBL	Inhibition of HIV-1 integrase	B	8.14	pIC50	7.24	nM	IC50	Eur J Med Chem (2010) 45: 3413-3419 [PMID:20488589]
ChEMBL	Inhibition of HIV-1 integrase strand transfer activity	B	8.14	pIC50	7.2	nM	IC50	Eur J Med Chem (2021) 225: 113787-113787 [PMID:34425310]
ChEMBL	Inhibition of HIV1 integrase strand transfer activity	B	8.14	pIC50	7.2	nM	IC50	Eur J Med Chem (2007) 42: 1159-1168 [PMID:17367896]
ChEMBL	Inhibition of recombinant HIV1 integrase strand transfer activity	B	8.14	pIC50	7.2	nM	IC50	J Med Chem (2006) 49: 1506-1508 [PMID:16509568]
ChEMBL	Inhibition of HIV1 integrase DNA strand transfer activity	B	8.15	pIC50	7	nM	IC50	J Med Chem (2008) 51: 5125-5129 [PMID:18665580]
ChEMBL	Inhibition of HIV1 integrase strand transfer activity	B	8.15	pIC50	7	nM	IC50	J Med Chem (2008) 51: 7717-7730 [PMID:19053754]
ChEMBL	Inhibition of strand transfer activity of Human immunodeficiency virus 1 Integrase using [3H]labeled target DNA as substrate after 45 mins by scintillation counting	B	8.22	pIC50	6	nM	IC50	Antimicrob Agents Chemother (2011) 55: 813-821 [PMID:21115794]
ChEMBL	Inhibition of Human immunodeficiency virus 1 integrase by strand transfer scintillation proximity assay	B	8.22	pIC50	6	nM	IC50	Antimicrob Agents Chemother (2008) 52: 901-908 [PMID:18160521]
ChEMBL	Inhibition of HIV1 integrase	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2010) 18: 5510-5518 [PMID:20630765]
ChEMBL	Inhibition of HIV-1 integrase after 1 hr by ELISA	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2011) 46: 756-764 [PMID:21227550]
ChEMBL	Inhibition of HIV1 integrase	B	8.4	pIC50	4	nM	IC50	J Med Chem (2008) 51: 7717-7730 [PMID:19053754]
ChEMBL	Inhibition of HIV1 integrase	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2891-2895 [PMID:18417342]
ChEMBL	Inhibition of Human immunodeficiency virus 1 integrase	B	8.42	pIC50	3.8	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2861-2869 [PMID:18541726]
ChEMBL	Inhibition of HIV integrase strand transfer activity	B	8.42	pIC50	3.8	nM	IC50	Bioorg Med Chem (2019) 27: 3836-3845 [PMID:31324562]
ChEMBL	Inhibition of HIV1 integrase by overall integration assay	B	8.7	pIC50	2	nM	IC50	J Med Chem (2008) 51: 5125-5129 [PMID:18665580]
ChEMBL	Inhibition of HIV1 integrase	B	8.74	pIC50	1.8	nM	IC50	Bioorg Med Chem (2015) 23: 3860-3868 [PMID:25907370]
ChEMBL	Inhibition of HIV-1 integrase mutant strand transfer activity incubated for 10 mins by enzymatic assay	B	9	pEC50	1	nM	EC50	Bioorg Med Chem (2022) 59: 116674-116674 [PMID:35202969]
ChEMBL	Inhibition of HIV-1 integrase strand transfer activity incubated for 10 mins by enzymatic assay	B	9.68	pEC50	0.21	nM	EC50	Bioorg Med Chem (2022) 59: 116674-116674 [PMID:35202969]
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	Inhibition of HIV1 RNase H function of recombinant reverse transcriptase using an 18-nt 3'-fluorescein-labeled RNA annealed to complementary 18-nt 5'-dabsyl-labeled DNA as substrate after 10 mins by fluorescence spectrometer analysis	B	4.04	pIC50	91000	nM	IC50	J Med Chem (2014) 57: 3223-3234 [PMID:24684270]
ChEMBL	Inhibition of RNase H function of HIV1 reverse transcriptase using DNA/RNA hybrid as substrate by fluorescence spectrometer analysis	B	4.04	pIC50	91000	nM	IC50	J Med Chem (2015) 58: 4610-4623 [PMID:25961960]
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit/N6-adenosine-methyltransferase catalytic subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4739695] [GtoPdb: 3181] [UniProtKB: Q86U44]
ChEMBL	Binding affinity to METTL3 (unknown origin) assessed as dissociation constant by SPR analysis	B	8.32	pKd	4.79	nM	Kd	J Med Chem (2023) 66: 1654-1677 [PMID:36692498]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]