azalanstat [Ligand Id: 8799] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL70611 (Azalanstat) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP11B1/Cytochrome P450 11B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908] [GtoPdb: 1359] [UniProtKB: P15538] | ||||||||
| ChEMBL | Binding affinity for corticoid 11-beta-hydroxylase | B | 7.46 | pKi | 35 | nM | Ki | J Med Chem (1993) 36: 2235-2237 [PMID:8340925] |
| CYP11B1 in Bovine [GtoPdb: 1359] | ||||||||
| GtoPdb | - | - | 7.46 | pKi | 35 | nM | Ki | J Med Chem (1993) 36: 2235-7 [PMID:8340925] |
| CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] | ||||||||
| ChEMBL | Binding affinity for cholesterol 17-alpha-hydroxylase | B | 5.79 | pKi | 1625 | nM | Ki | J Med Chem (1993) 36: 2235-2237 [PMID:8340925] |
| ChEMBL | Binding affinity for progesterone 17-alpha,20-lyase | B | 6.35 | pKi | 447 | nM | Ki | J Med Chem (1993) 36: 2235-2237 [PMID:8340925] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Binding affinity for Cytochrome P450 19A1 | B | 8.12 | pKi | 7.6 | nM | Ki | J Med Chem (1993) 36: 2235-2237 [PMID:8340925] |
| GtoPdb | - | - | 8.12 | pKi | 7.6 | nM | Ki | J Med Chem (1993) 36: 2235-7 [PMID:8340925] |
| Haem oxygenase 1/Heme oxygenase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5035] [GtoPdb: 1441] [UniProtKB: P06762] | ||||||||
| ChEMBL | In vitro inhibitory concentration against heme oxygenase 1 from rat spleen | B | 5.22 | pIC50 | 6000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1457-1461 [PMID:15713406] |
| ChEMBL | Inhibition of Sprague-Dawley rat spleen HO1 | B | 5.22 | pIC50 | 6000 | nM | IC50 | J Med Chem (2006) 49: 4437-4441 [PMID:16821802] |
| ChEMBL | Inhibition of heme oxygenase 1 in Sprague-Dawley rat spleen microsomal fraction assessed as decrease in bilirubin formation using biliverdin reductase as substrate after 60 mins by spectrophotometric method | B | 5.22 | pIC50 | 6000 | nM | IC50 | Eur J Med Chem (2018) 158: 937-950 [PMID:30261468] |
| ChEMBL | Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | B | 5.26 | pIC50 | 5500 | nM | IC50 | Bioorg Med Chem (2013) 21: 5145-5153 [PMID:23867390] |
| ChEMBL | Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay | B | 5.28 | pIC50 | 5300 | nM | IC50 | Eur J Med Chem (2018) 148: 54-62 [PMID:29454190] |
| ChEMBL | Inhibition of Sprague-Dawley rat spleen microsome HO1 | B | 5.28 | pIC50 | 5300 | nM | IC50 | Bioorg Med Chem (2007) 15: 3225-3234 [PMID:17339115] |
| ChEMBL | Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry | B | 5.28 | pIC50 | 5300 | nM | IC50 | J Med Chem (2021) 64: 13373-13393 [PMID:34472337] |
| Haem oxygenase 2/Heme oxygenase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3348] [GtoPdb: 1442] [UniProtKB: P23711] | ||||||||
| ChEMBL | In vitro inhibitory concentration against heme oxygenase 2 from rat brain | B | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1457-1461 [PMID:15713406] |
| ChEMBL | Inhibition of Sprague-Dawley rat brain HO2 | B | 4.55 | pIC50 | 28000 | nM | IC50 | J Med Chem (2006) 49: 4437-4441 [PMID:16821802] |
| ChEMBL | Inhibition of Sprague-Dawley rat brain microsome HO2 | B | 4.61 | pIC50 | 24500 | nM | IC50 | Bioorg Med Chem (2007) 15: 3225-3234 [PMID:17339115] |
| ChEMBL | Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis | B | 4.61 | pIC50 | 24500 | nM | IC50 | Bioorg Med Chem (2013) 21: 5145-5153 [PMID:23867390] |
| ChEMBL | Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay | B | 4.61 | pIC50 | 24400 | nM | IC50 | Eur J Med Chem (2018) 148: 54-62 [PMID:29454190] |
| ChEMBL | Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry | B | 4.61 | pIC50 | 24400 | nM | IC50 | J Med Chem (2021) 64: 13373-13393 [PMID:34472337] |
| CYP51A1 in Human [GtoPdb: 1374] [UniProtKB: Q16850] | ||||||||
| GtoPdb | - | - | 9.1 | pKi | 0.79 | nM | Ki | J Med Chem (1993) 36: 2235-7 [PMID:8340925] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
