ChEMBL ligand: CHEMBL70611 (Azalanstat)
CYP11B1/Cytochrome P450 11B1 in Human [ChEMBL: CHEMBL1908] [GtoPdb: 1359] [UniProtKB: P15538] CYP11B1 in Bovine [GtoPdb: 1359] There should be some charts here, you may need to enable JavaScript!
CYP17A1/Cytochrome P450 17A1 in Human [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
Haem oxygenase 1/Heme oxygenase 1 in Rat [ChEMBL: CHEMBL5035] [GtoPdb: 1441] [UniProtKB: P06762] There should be some charts here, you may need to enable JavaScript!
Haem oxygenase 2/Heme oxygenase 2 in Rat [ChEMBL: CHEMBL3348] [GtoPdb: 1442] [UniProtKB: P23711] There should be some charts here, you may need to enable JavaScript!
CYP51A1 in Human [GtoPdb: 1374] [UniProtKB: Q16850] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP11B1/Cytochrome P450 11B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1908] [GtoPdb: 1359] [UniProtKB: P15538]
ChEMBL	Binding affinity for corticoid 11-beta-hydroxylase	B	7.46	pKi	35	nM	Ki	J Med Chem (1993) 36: 2235-2237 [PMID:8340925]
CYP11B1 in Bovine [GtoPdb: 1359]
GtoPdb	-	-	7.46	pKi	35	nM	Ki	J Med Chem (1993) 36: 2235-7 [PMID:8340925]
CYP17A1/Cytochrome P450 17A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3522] [GtoPdb: 1361] [UniProtKB: P05093]
ChEMBL	Binding affinity for cholesterol 17-alpha-hydroxylase	B	5.79	pKi	1625	nM	Ki	J Med Chem (1993) 36: 2235-2237 [PMID:8340925]
ChEMBL	Binding affinity for progesterone 17-alpha,20-lyase	B	6.35	pKi	447	nM	Ki	J Med Chem (1993) 36: 2235-2237 [PMID:8340925]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Binding affinity for Cytochrome P450 19A1	B	8.12	pKi	7.6	nM	Ki	J Med Chem (1993) 36: 2235-2237 [PMID:8340925]
GtoPdb	-	-	8.12	pKi	7.6	nM	Ki	J Med Chem (1993) 36: 2235-7 [PMID:8340925]
Haem oxygenase 1/Heme oxygenase 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5035] [GtoPdb: 1441] [UniProtKB: P06762]
ChEMBL	In vitro inhibitory concentration against heme oxygenase 1 from rat spleen	B	5.22	pIC50	6000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1457-1461 [PMID:15713406]
ChEMBL	Inhibition of Sprague-Dawley rat spleen HO1	B	5.22	pIC50	6000	nM	IC50	J Med Chem (2006) 49: 4437-4441 [PMID:16821802]
ChEMBL	Inhibition of heme oxygenase 1 in Sprague-Dawley rat spleen microsomal fraction assessed as decrease in bilirubin formation using biliverdin reductase as substrate after 60 mins by spectrophotometric method	B	5.22	pIC50	6000	nM	IC50	Eur J Med Chem (2018) 158: 937-950 [PMID:30261468]
ChEMBL	Inhibition of Sprague-Dawley rat spleen microsomal HO-1 assessed as bilirubin formation after 60 mins by spectrophotometric analysis	B	5.26	pIC50	5500	nM	IC50	Bioorg Med Chem (2013) 21: 5145-5153 [PMID:23867390]
ChEMBL	Inhibition of HO-1 in Sprague-Dawley albino rat spleen microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay	B	5.28	pIC50	5300	nM	IC50	Eur J Med Chem (2018) 148: 54-62 [PMID:29454190]
ChEMBL	Inhibition of Sprague-Dawley rat spleen microsome HO1	B	5.28	pIC50	5300	nM	IC50	Bioorg Med Chem (2007) 15: 3225-3234 [PMID:17339115]
ChEMBL	Inhibition of Sprague-Dawley rat spleen microsome HO-1 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry	B	5.28	pIC50	5300	nM	IC50	J Med Chem (2021) 64: 13373-13393 [PMID:34472337]
Haem oxygenase 2/Heme oxygenase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3348] [GtoPdb: 1442] [UniProtKB: P23711]
ChEMBL	In vitro inhibitory concentration against heme oxygenase 2 from rat brain	B	4.55	pIC50	28000	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1457-1461 [PMID:15713406]
ChEMBL	Inhibition of Sprague-Dawley rat brain HO2	B	4.55	pIC50	28000	nM	IC50	J Med Chem (2006) 49: 4437-4441 [PMID:16821802]
ChEMBL	Inhibition of Sprague-Dawley rat brain microsome HO2	B	4.61	pIC50	24500	nM	IC50	Bioorg Med Chem (2007) 15: 3225-3234 [PMID:17339115]
ChEMBL	Inhibition of Sprague-Dawley rat brain HO-2 assessed as bilirubin formation after 60 mins by spectrophotometric analysis	B	4.61	pIC50	24500	nM	IC50	Bioorg Med Chem (2013) 21: 5145-5153 [PMID:23867390]
ChEMBL	Inhibition of HO-2 in Sprague-Dawley albino rat brain microsomes assessed as reduction in bilirubin formation using hemin as substrate after 60 mins in presence of NADPH by biliverdin reductase enzyme coupled spectrophotometric assay	B	4.61	pIC50	24400	nM	IC50	Eur J Med Chem (2018) 148: 54-62 [PMID:29454190]
ChEMBL	Inhibition of Sprague-Dawley rat brain microsome HO-2 assessed as bilirubin formation incubated for 60 mins by double-beam spectrophotometry	B	4.61	pIC50	24400	nM	IC50	J Med Chem (2021) 64: 13373-13393 [PMID:34472337]
CYP51A1 in Human [GtoPdb: 1374] [UniProtKB: Q16850]
GtoPdb	-	-	9.1	pKi	0.79	nM	Ki	J Med Chem (1993) 36: 2235-7 [PMID:8340925]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]