ChEMBL ligand: CHEMBL90593 (Biolaif, Dehydroandrosterone, Dehydroepiandrosterone, Dehydroisoandrosterone, Dhea, EM-760, Enzymatic therapy, Intrarosa, Natrol dhea, NSC-9896, Prasterone, Vaginorm)
Beta-glucuronidase in Human [ChEMBL: CHEMBL2728] [UniProtKB: P08236] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7] Glucose-6-phosphate 1-dehydrogenase in Human [ChEMBL: CHEMBL5347] [UniProtKB: P11413] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta-glucuronidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2728] [UniProtKB: P08236]
ChEMBL	Inhibition of beta-glucuronidase (unknown origin)	B	4.11	pIC50	77900	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5	pKi	10000	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7]
ChEMBL	Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot	B	5.77	pKi	1700	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of Trypanosoma brucei G6PDH using NADP as substrate by Lineweaver-Burke plot	B	5.96	pKi	1100	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
Glucose-6-phosphate 1-dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5347] [UniProtKB: P11413]
ChEMBL	Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot	B	5.05	pKi	8900	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of human G6PDH using NADP as substrate by Lineweaver-Burke plot	B	5.21	pKi	6200	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide	B	4.6	pIC50	24900	nM	IC50	J Med Chem (2012) 55: 4431-4445 [PMID:22506561]
ChEMBL	Inhibition of G6PD (unknown origin) assessed as reduction in 6-phospho-D-glucono-1,5-lactone and NADPH production using glucose-6-phosphate and NADP+ as substrate incubated for 15 mins by UV absorption photometry assay	B	4.9	pIC50	12460	nM	IC50	Bioorg Med Chem Lett (2021) 40: 127905-127905 [PMID:33689874]
ChEMBL	Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay	B	4.95	pIC50	11300	nM	IC50	J Med Chem (2012) 55: 4431-4445 [PMID:22506561]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	5.48	pEC50	3330	nM	EC50	J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
ChEMBL	Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy	B	5	pEC50	>10000	nM	EC50	Bioorg Med Chem Lett (2014) 24: 3480-3485 [PMID:24928400]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	7.84	pKd	14.45	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]