ChEMBL ligand: CHEMBL90593 (Biolaif, Dehydroandrosterone, Dehydroepiandrosterone, Dehydroisoandrosterone, Dhea, EM-760, Enzymatic therapy, Intrarosa, Natrol dhea, NSC-9896, Prasterone, Vaginorm)
Beta-glucuronidase in Human [ChEMBL: CHEMBL2728] [UniProtKB: P08236] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7] Glucose-6-phosphate 1-dehydrogenase in Human [ChEMBL: CHEMBL5347] [UniProtKB: P11413] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Beta-glucuronidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2728] [UniProtKB: P08236]
ChEMBL	Inhibition of beta-glucuronidase (unknown origin)	B	4.11	pIC50	77900	nM	IC50	Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	5	pKi	10000	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7]
ChEMBL	Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot	B	5.77	pKi	1700	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of Trypanosoma brucei G6PDH using NADP as substrate by Lineweaver-Burke plot	B	5.96	pKi	1100	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
Glucose-6-phosphate 1-dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5347] [UniProtKB: P11413]
ChEMBL	Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot	B	5.05	pKi	8900	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of human G6PDH using NADP as substrate by Lineweaver-Burke plot	B	5.21	pKi	6200	nM	Ki	Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL	Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide	B	4.6	pIC50	24900	nM	IC50	J Med Chem (2012) 55: 4431-4445 [PMID:22506561]
ChEMBL	Inhibition of G6PD (unknown origin) assessed as reduction in 6-phospho-D-glucono-1,5-lactone and NADPH production using glucose-6-phosphate and NADP+ as substrate incubated for 15 mins by UV absorption photometry assay	B	4.9	pIC50	12460	nM	IC50	Bioorg Med Chem Lett (2021) 40: 127905-127905 [PMID:33689874]
ChEMBL	Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay	B	4.95	pIC50	11300	nM	IC50	J Med Chem (2012) 55: 4431-4445 [PMID:22506561]
ChEMBL	Inhibition of G6PD (unknown origin)	B	4.95	pIC50	11300	nM	IC50	J Med Chem (2022) 65: 4403-4423 [PMID:35239352]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	5.48	pEC50	3330	nM	EC50	J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
ChEMBL	Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy	B	5	pEC50	>10000	nM	EC50	Bioorg Med Chem Lett (2014) 24: 3480-3485 [PMID:24928400]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	7.84	pKd	14.45	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]