dehydroepiandrosterone [Ligand Id: 2370] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL90593 (Dehydroepiandrosterone, EM-760, Dhea, Enzymatic Therapy, Prasterone, Intrarosa, Dehydroandrosterone, Natrol DHEA, NSC-9896)
  • Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
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  • Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7]
  • Glucose-6-phosphate 1-dehydrogenase in Human [ChEMBL: CHEMBL5347] [UniProtKB: P11413]
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  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
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  • Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL Binding affinity to human CBG receptor (corticosteroid-binding globulins) B 5 pKi 10000 nM Ki J. Med. Chem. (2004) 47: 2732-2742 [PMID:15139751]
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7]
ChEMBL Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot B 5.77 pKi 1700 nM Ki Bioorg. Med. Chem. (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL Inhibition of Trypanosoma brucei G6PDH using NADP as substrate by Lineweaver-Burke plot B 5.96 pKi 1100 nM Ki Bioorg. Med. Chem. (2009) 17: 2483-2489 [PMID:19231202]
Glucose-6-phosphate 1-dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5347] [UniProtKB: P11413]
ChEMBL Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot B 5.05 pKi 8900 nM Ki Bioorg. Med. Chem. (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL Inhibition of human G6PDH using NADP as substrate by Lineweaver-Burke plot B 5.21 pKi 6200 nM Ki Bioorg. Med. Chem. (2009) 17: 2483-2489 [PMID:19231202]
ChEMBL Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide B 4.6 pIC50 24900 nM IC50 J. Med. Chem. (2012) 55: 4431-4445 [PMID:22506561]
ChEMBL Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay B 4.95 pIC50 11300 nM IC50 J. Med. Chem. (2012) 55: 4431-4445 [PMID:22506561]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL Agonist activity at human TGR5 expressed in CHO cells by luciferase assay F 5.48 pEC50 3330 nM EC50 J. Med. Chem. (2008) 51: 1831-1841 [PMID:18307294]
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9]
ChEMBL Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy B 5 pEC50 >10000 nM EC50 Bioorg. Med. Chem. Lett. (2014) 24: 3480-3485 [PMID:24928400]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin B 7.84 pKd 14.45 nM Kd J. Med. Chem. (2008) 51: 2047-2056 [PMID:18330978]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]