Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL90593 (Biolaif, Dehydroandrosterone, Dehydroepiandrosterone, Dehydroisoandrosterone, Dhea, EM-760, Enzymatic therapy, Intrarosa, Natrol dhea, NSC-9896, Prasterone, Vaginorm) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Beta-glucuronidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2728] [UniProtKB: P08236] | ||||||||
ChEMBL | Inhibition of beta-glucuronidase (unknown origin) | B | 4.11 | pIC50 | 77900 | nM | IC50 | Eur J Med Chem (2020) 187: 111921-111921 [PMID:31835168] |
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185] | ||||||||
ChEMBL | Binding affinity to human CBG receptor (corticosteroid-binding globulins) | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2004) 47: 2732-2742 [PMID:15139751] |
Glucose-6-phosphate 1-dehydrogenase in Trypanosoma brucei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5672] [UniProtKB: Q9GRG7] | ||||||||
ChEMBL | Inhibition of Trypanosoma brucei G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot | B | 5.77 | pKi | 1700 | nM | Ki | Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202] |
ChEMBL | Inhibition of Trypanosoma brucei G6PDH using NADP as substrate by Lineweaver-Burke plot | B | 5.96 | pKi | 1100 | nM | Ki | Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202] |
Glucose-6-phosphate 1-dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5347] [UniProtKB: P11413] | ||||||||
ChEMBL | Inhibition of human G6PDH using glucose-6-phosphate as substrate by Lineweaver-Burke plot | B | 5.05 | pKi | 8900 | nM | Ki | Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202] |
ChEMBL | Inhibition of human G6PDH using NADP as substrate by Lineweaver-Burke plot | B | 5.21 | pKi | 6200 | nM | Ki | Bioorg Med Chem (2009) 17: 2483-2489 [PMID:19231202] |
ChEMBL | Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide | B | 4.6 | pIC50 | 24900 | nM | IC50 | J Med Chem (2012) 55: 4431-4445 [PMID:22506561] |
ChEMBL | Inhibition of G6PD (unknown origin) assessed as reduction in 6-phospho-D-glucono-1,5-lactone and NADPH production using glucose-6-phosphate and NADP+ as substrate incubated for 15 mins by UV absorption photometry assay | B | 4.9 | pIC50 | 12460 | nM | IC50 | Bioorg Med Chem Lett (2021) 40: 127905-127905 [PMID:33689874] |
ChEMBL | Inhibition of human recombinant N-terminal His tagged G6PD expressed in Escherichia coli JM109 (DE3) cells assessed as production of NADPH after 30 mins by Amplite fluorimetric assay | B | 4.95 | pIC50 | 11300 | nM | IC50 | J Med Chem (2012) 55: 4431-4445 [PMID:22506561] |
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
ChEMBL | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | F | 5.48 | pEC50 | 3330 | nM | EC50 | J Med Chem (2008) 51: 1831-1841 [PMID:18307294] |
NPC1 like intracellular cholesterol transporter 1/Niemann-Pick C1-like protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2027] [GtoPdb: 2629] [UniProtKB: Q9UHC9] | ||||||||
ChEMBL | Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2014) 24: 3480-3485 [PMID:24928400] |
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278] | ||||||||
ChEMBL | Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin | B | 7.84 | pKd | 14.45 | nM | Kd | J Med Chem (2008) 51: 2047-2056 [PMID:18330978] |
ChEMBL data shown on this page come from version 32:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]