avibactam   

GtoPdb Ligand ID: 10761

Synonyms: AVI | NXL 104 | NXL-104 | NXL104
avibactam is an approved drug (FDA (2015), EMA (2016))
Compound class: Synthetic organic
Comment: Avibactam (NXL104) is non-β-lactam β-lactamase inhibitor [1]. It has activity against class A and C serine β-lactamases, including Klebsiella pneumoniae carbapenemases.
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 138.62
Molecular weight 265.04
XLogP -3.2
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
Isomeric SMILES NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
InChI InChI=1S/C7H11N3O6S/c8-6(11)5-2-1-4-3-9(5)7(12)10(4)16-17(13,14)15/h4-5H,1-3H2,(H2,8,11)(H,13,14,15)/t4-,5+/m1/s1
InChI Key NDCUAPJVLWFHHB-UHNVWZDZSA-N
Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (2015), EMA (2016))
IUPAC Name
[(2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl] hydrogen sulfate
International Nonproprietary Names
INN number INN
8972 avibactam
Synonyms
AVI | NXL 104 | NXL-104 | NXL104
Database Links
Specialist databases
AntibioticDB 71, 72
Other databases
BindingDB Ligand 50339145
CAS Registry No. 1192500-31-4 (source: WHO INN record)
ChEMBL Ligand CHEMBL1689063
GtoPdb PubChem SID 405560202
PubChem CID 9835049
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