compound 11d [DOI: 10.1039/c0md00194e] [Ligand Id: 8197] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3221815
  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
  • Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Rat [ChEMBL: CHEMBL5490] [GtoPdb: 1504] [UniProtKB: Q62868]
  • This target only has 0 pki data point
1 CHEMBL3221815_lig_chart_1 Rho-associated protein kinase 2 HumanRat
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  • CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
  • This target only has 0 pki data point
2 CHEMBL3221815_lig_chart_2 Serine/threonine-protein kinase MRCK-A Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2973] [GtoPdb: 1504] [UniProtKB: O75116]
GtoPdb - - 9 pIC50 <1 nM IC50 Medchemcomm (2011) 2: 73-75
ChEMBL Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assay B 9 pIC50 <1 nM IC50 MedChemComm (2011) 2: 73-75
Rho associated coiled-coil containing protein kinase 2/Rho-associated protein kinase 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5490] [GtoPdb: 1504] [UniProtKB: Q62868]
ChEMBL Inhibition of ROCK2-mediated myosin light chain bis-phosphorylation in rat A7r5 cells after 1 hr by TO-PRO-3 iodide staining-based assay B 8.4 pIC50 <4 nM IC50 MedChemComm (2011) 2: 73-75
CDC42 binding protein kinase alpha/Serine/threonine-protein kinase MRCK-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4516] [GtoPdb: 1507] [UniProtKB: Q5VT25]
GtoPdb - - 7.13 pIC50 74 nM IC50 Medchemcomm (2011) 2: 73-75
ChEMBL Inhibition of MRCK-alpha (unknown origin) using LCB-AKRRRLSSLRA-NH2 as substrate after 75 mins by luminescence assay B 7.13 pIC50 74 nM IC50 MedChemComm (2011) 2: 73-75

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]