ChEMBL ligand: CHEMBL490820
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a in SARS-CoV-2 [GtoPdb: 3111, 3124] [UniProtKB: P0DTC1] CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	Inhibition of SARS-CoV-2 3CL protease using HiLyte Fluor488TM-ESATLQSGLRKAK-QXL520TM-NH2 as substrate measured after 5 hrs by FRET assay	B	6.49	pIC50	320	nM	IC50	RSC Med Chem (2023) 14: 9-21 [PMID:36760740]
ChEMBL	Inhibition of his-tagged SARS CoV-2 main protease expressed in HEK cells using Boc-Abu-Tle-Leu-Gln-AMC as substrate	B	6.5	pIC50	313	nM	IC50	J Med Chem (2022) 65: 9376-9395 [PMID:35709506]
ChEMBL	Inhibition of SARA-CoV-2 Main protease using Dabcyl-KTSAVLQSGFRKM-E(Edans)-NH2 as substrate by FRET assay	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2023) 257: 115491-115491 [PMID:37244162]
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a in SARS-CoV-2 [GtoPdb: 3111, 3124] [UniProtKB: P0DTC1]
GtoPdb	-	-	7.3	pIC50	50	nM	IC50	MPro Activity Data. postera.ai/covid/activity_data
CoV 3C-like (main) protease/CoV Replicase polyprotein 1a/SARS coronavirus 3C-like proteinase in Severe acute respiratory syndrome-related coronavirus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3927] [GtoPdb: 3111, 3124] [UniProtKB: P0C6U8]
ChEMBL	Inhibition of SARS 3Clpro measured by rate of reaction	B	5.16	pEC50	6900	nM	EC50	Bioorg Med Chem Lett (2008) 18: 5684-5688 [PMID:18796354]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]