ChEMBL ligand: CHEMBL1397 (Noxafil, Noxafil powdermix kit, (-)-posaconazole, Posaconazole, SCH 56592, SCH-56592)
14-alpha sterol demethylase in Neosartorya fumigata (Aspergillus fumigatus) [ChEMBL: CHEMBL1681624] [UniProtKB: Q96W81] There should be some charts here, you may need to enable JavaScript!
14-alpha sterol demethylase Cyp51A in Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) [ChEMBL: CHEMBL1681623] [UniProtKB: Q4WNT5] There should be some charts here, you may need to enable JavaScript!
CYP8B1/7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase in Human [ChEMBL: CHEMBL4523494] [GtoPdb: 1357] [UniProtKB: Q9UNU6] There should be some charts here, you may need to enable JavaScript!
Cytochrome P450 51 in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL1780] [UniProtKB: P10613] There should be some charts here, you may need to enable JavaScript!
Lanosterol 14-alpha demethylase in Aspergillus [ChEMBL: CHEMBL3390824] [UniProtKB: A0A2P2HJL8, G4WW85, Q9P8R0] There should be some charts here, you may need to enable JavaScript!
Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
14-alpha sterol demethylase in Neosartorya fumigata (Aspergillus fumigatus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681624] [UniProtKB: Q96W81]
ChEMBL	Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme B expressed in Escherichia coli assessed as tight binding affinity constant	B	7.14	pKd	73	nM	Kd	Antimicrob Agents Chemother (2010) 54: 4225-4234 [PMID:20660663]
14-alpha sterol demethylase Cyp51A in Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1681623] [UniProtKB: Q4WNT5]
ChEMBL	Binding affinity to Aspergillus fumigatus AF293 sterol 14-alpha demethylase isoenzyme A expressed in Escherichia coli	B	5.57	pKd	2690	nM	Kd	Antimicrob Agents Chemother (2010) 54: 4225-4234 [PMID:20660663]
CYP8B1/7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523494] [GtoPdb: 1357] [UniProtKB: Q9UNU6]
ChEMBL	Inhibition of CYP8B1 in human liver microsomes using D7-7alpha-hydroxy-4-cholesten-3-one as substrate preincubated for 20 mins followed by substrate addition in presence of NADPH by UPLC-ESI-MS/MS analysis	B	5.42	pIC50	3800	nM	IC50	WO-2014018375-A1. Cyp8b1 and uses thereof in therapeutic and diagnostic methods (null)
Cytochrome P450 51 in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1780] [UniProtKB: P10613]
ChEMBL	Binding affinity to Candida albicans CYP51 by spectral titration method	B	7.09	pKd	81	nM	Kd	J Med Chem (2018) 61: 5679-5691 [PMID:29894182]
Lanosterol 14-alpha demethylase in Aspergillus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3390824] [UniProtKB: A0A2P2HJL8, G4WW85, Q9P8R0]
ChEMBL	Binding affinity to Aspergillus fumigatus CYP51 by spectral titration method	B	6.88	pKd	131	nM	Kd	J Med Chem (2018) 61: 5679-5691 [PMID:29894182]
Sterol 14-alpha demethylase in Trypanosoma cruzi (strain CL Brener) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075110] [UniProtKB: Q7Z1V1]
ChEMBL	Binding affinity to Trypanosoma cruzi recombinant full length CYP51 by spectrophotometric analysis	B	7.22	pKd	60	nM	Kd	J Med Chem (2013) 56: 2556-2567 [PMID:23448316]
ChEMBL	Binding affinity to full length Trypanosoma cruzi Tulahuen C4 C-terminal His-tagged CYP51 expressed in Escherichia coli HMS174 (DE3) assessed as induction of shift in Soret band by spectrophotometry	B	7.74	pKd	18	nM	Kd	Bioorg Med Chem Lett (2020) 30: 126778-126778 [PMID:31706668]
ChEMBL	Inhibition of recombinant Trypanosoma cruzi Tulahuen CYP51 expressed in Escherichia coli JM109 cell membranes assessed as inhibition of microbe growth by fluorescence based analysis	B	7.32	pIC50	48	nM	IC50	Eur J Med Chem (2018) 149: 257-268 [PMID:29501946]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]