PRN1371

Ligand id: 9788

Name: PRN1371

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 101.82
Molecular weight 560.17
XLogP 4.05
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one
Synonyms
compound 34 [PMID: 28665128] | PRN-1371
Comments
PRN1371 is an irreversible (covalent) and potent FGFR inhibitor that is being developed for antineoplastic potential [1]. It is highly selective for FGFR1-4 compared to other kinase enzymes.
Database Links
CAS Registry No. 1802929-43-6 (source: PubChem)
GtoPdb PubChem SID 354702261
PubChem CID 118295624
Search Google for chemical match using the InChIKey PUIXMSRTTHLNKI-UHFFFAOYSA-N
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Search UniChem for chemical match using the InChIKey PUIXMSRTTHLNKI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone PUIXMSRTTHLNKI