warfarin [Ligand Id: 6853] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1464 (NSC-59813, Warfarin)
  • Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
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  • proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
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  • vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL Tested for the HIV Protease inhibitory activity of the compound F 4.52 pIC50 ~30000 nM IC50 J Med Chem (1994) 37: 3200-3204 [PMID:7932546]
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
ChEMBL Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay B 4.61 pIC50 24590 nM IC50 J Nat Prod (2011) 74: 1353-1357 [PMID:21510613]
vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6]
GtoPdb - - 5.58 pKi 2633 nM Ki Biochim Biophys Acta (2013) 1830: 4202-10 [PMID:23618698]
ChEMBL Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA B 8.06 pIC50 8.8 nM IC50 Bioorg Med Chem Lett (2019) 29: 1954-1956 [PMID:31147103]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]