warfarin [Ligand Id: 6853] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1464 (NSC-59813, Warfarin)
  • Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
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  • proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
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  • vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Human immunodeficiency virus type 1 protease in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL243] [UniProtKB: Q72874]
ChEMBL Tested for the HIV Protease inhibitory activity of the compound F 4.52 pIC50 ~30000 nM IC50 J. Med. Chem. (1994) 37: 3200-3204 [PMID:7932546]
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
ChEMBL Inhibition of recombinant type 8 subtilisin using Arg-Glu-(EDANS)- Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln-Lys-(DALBCYL)-Arg fluorogenic substrate preincubated for 1 hr measured after 1 hr at 1 min interval by fluorescence assay B 4.61 pIC50 24590 nM IC50 J. Nat. Prod. (2011) 74: 1353-1357 [PMID:21510613]
vitamin K epoxide reductase complex subunit 1/Vitamin k epoxide reductase complex subunit 1 isoform 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1930] [GtoPdb: 2645] [UniProtKB: Q9BQB6]
GtoPdb - - 5.58 pKi 2633 nM Ki Biochim Biophys Acta (2013) 1830: 4202-10 [PMID:23618698]
ChEMBL Inhibition of VKOR (unknown origin) in HEK293 expressing FIXgla-PC incubated for 48 hrs by ELISA B 8.06 pIC50 8.8 nM IC50 Bioorg Med Chem Lett (2019) 29: 1954-1956 [PMID:31147103]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]