GM-CSF

Ligand id: 4942

Name: GM-CSF

Species: Human

Classification
Compound class Endogenous peptide in human, mouse or rat
Synonyms
colony-stimulating factor | CSF
Comments
GM-CSF as a target in inflammatory/autoimmune disease was reviewed by Hamilton (2015) [3]. An anti-GM-CSF mAb called MOR 103 (GSK3196165) is reported to have exhibited preliminary evidence of efficacy in patients with active RA in Phase 1b/2 clinical trial (NCT01023256) [2]. There are currently no active MOR103 or GSK3196165 trials registered with ClinicalTrials.gov.
Gene/Precursor
Gene symbol Gene name Species Precursor protein name Synonyms
CSF2 colony stimulating factor 2 Human prepro-colony stimulating factor 2 (granulocyte macrophage) colony stimulating factor 2 (granulocyte-macrophage), GMCSF, GM-CSF, granulocyte-macrophage colony stimulating factor, molgramostin
Database Links
Ensembl Gene ENSG00000164400 (Hs)
GtoPdb PubChem SID 178101640
Human Protein Atlas ENSG00000164400 (Hs)
UniProtKB P04141 (Hs)
Wikipedia Granulocyte_macrophage_colony-stimulating_factor