GM-CSF

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Ligands
GM-CSF (Human)

Ligand id: 4942

Name: GM-CSF

Species: Human

Classification
Compound class	Endogenous peptide in human, mouse or rat

Synonyms
colony-stimulating factor \| CSF

Synonyms

colony-stimulating factor | CSF

Comments
GM-CSF as a target in inflammatory/autoimmune disease was reviewed by Hamilton (2015) [3]. An anti-GM-CSF mAb called MOR 103 (GSK3196165) is reported to have exhibited preliminary evidence of efficacy in patients with active RA in Phase 1b/2 clinical trial (NCT01023256) [2]. There are currently no active MOR103 or GSK3196165 trials registered with ClinicalTrials.gov.

Comments

GM-CSF as a target in inflammatory/autoimmune disease was reviewed by Hamilton (2015) [3]. An anti-GM-CSF mAb called MOR 103 (GSK3196165) is reported to have exhibited preliminary evidence of efficacy in patients with active RA in Phase 1b/2 clinical trial (NCT01023256) [2]. There are currently no active MOR103 or GSK3196165 trials registered with ClinicalTrials.gov.

Gene/Precursor

Gene symbol	Gene name	Species	Precursor protein name	Synonyms
CSF2	colony stimulating factor 2	Human	prepro-colony stimulating factor 2 (granulocyte macrophage)	colony stimulating factor 2 (granulocyte-macrophage), GMCSF, GM-CSF, granulocyte-macrophage colony stimulating factor, molgramostin

Database Links
Ensembl Gene	ENSG00000164400 (Hs)
GtoPdb PubChem SID	178101640
Human Protein Atlas	ENSG00000164400 (Hs)
UniProtKB	P04141 (Hs)
Wikipedia	Granulocyte_macrophage_colony-stimulating_factor