GM-CSF   Click here for help

GtoPdb Ligand ID: 4942

Synonyms: colony-stimulating factor | CSF
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: GM-CSF as a target in inflammatory/autoimmune disease was reviewed by Hamilton (2015) [2].
Species: Human
Peptide Sequence Click here for help
APARSPSPSTQPWEHVNAIQEARRLLNLSRDTAAEMNETVEVISEMFDLQEPTCLQTRLELYKQGLRGSLTKLKGPLTMM
ASHYKQHCPPTPETSCATQIITFESFKENLKDFLLVIPFDCWEPVQE
Selected 3D Structures
PDB Id: 2gmf
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
O-linked glycosylation of serine residues at positions 5, 7 and 9; O-linked glycosylation of threonine residue at position 10; N-linked glycosylation of asparagine residues at positions 27 and 37; disulphide bond formation between cysteine residues at positions 54 and 96, and 88 and 121