GM-CSF   Click here for help

GtoPdb Ligand ID: 4942

Synonyms: colony-stimulating factor | CSF
Immunopharmacology Ligand
Comment: GM-CSF as a target in inflammatory/autoimmune disease was reviewed by Hamilton (2015) [2].
Species: Human
Immunopharmacology Comments
GM-CSF is a cytokine that augments proliferation, differentiation, and maturation of granulocytes and is implicated in several chronic inflammatory diseases, including severe asthma [3] and rheumatoid arthrtis. Cytokine-neutralising experiments have showed GM-CSF to be a contributor to the anti-apoptotic activity of neutrophils generated by airway epithelial conditioned medium from more severe asthmatics [7]. Monoclonal antibodies that target GM-CSF are in advanced clinical development.