GM-CSF

Ligand id: 4942

Name: GM-CSF

Species: Human

Natural/Endogenous Targets
Target
colony stimulating factor 1 receptor
GM-CSF receptor, α subunit
Granulocyte macrophage colony-stimulating factor receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF receptor, α subunit Hs Agonist Agonist - - -
colony stimulating factor 1 receptor Hs None - - - -
Granulocyte macrophage colony-stimulating factor receptor Hs Agonist Agonist - - -
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
gimsilumab Hs Antibody Binding 10.8 – 11.0 pKd - 6
pKd 10.8 – 11.0 (Kd 1.7x10-11 – 1.1x10-11 M) [6]
Description: Binding affinity to recombinant hGM-CSF measured by BIACORE surface plasmon resonance.
namilumab Hs Antibody Binding 10.3 pKd - 5
pKd 10.3 (Kd 4.6x10-11 M) [5]
lenzilumab Hs Antibody Binding >10.0 pKd - 1
pKd >10.0 (Kd <1x10-10 M) [1]