vofopitant [Ligand Id: 5752] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL522302 (GR205171, Vofopitant, Gr-205171, GR-205171)
  • NK1 receptor/Neurokinin 1 receptor in Human [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103]
ChEMBL Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells B 10.3 pKi 0.05 nM Ki J. Med. Chem. (2009) 52: 3238-3247 [PMID:19388677]
GtoPdb - - 10.6 pKi - - Ki Regul Pept (1996) 65: 45-53 [PMID:8876035]
ChEMBL Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells B 10.1 pIC50 0.08 nM IC50 J. Med. Chem. (1998) 41: 4607-4614 [PMID:9804700]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]