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ChEMBL ligand: CHEMBL522302 (Gr-205171, GR-205171, GR205171, Vofopitant) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
ChEMBL | Displacement of [3H]substance P from human recombinant NK1 receptor expressed in CHO cells | B | 10.3 | pKi | 0.05 | nM | Ki | J Med Chem (2009) 52: 3238-3247 [PMID:19388677] |
GtoPdb | - | - | 10.6 | pKi | - | - | Ki | Regul Pept (1996) 65: 45-53 [PMID:8876035] |
ChEMBL | Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cells | B | 10.1 | pIC50 | 0.08 | nM | IC50 | J Med Chem (1998) 41: 4607-4614 [PMID:9804700] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]