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ChEMBL ligand: CHEMBL3648680 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
ChEMBL | Antagonist activity at alpha 1a adrenergic receptor (unknown origin) | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] | ||||||||
ChEMBL | Inhibition of GSK3beta in human human MM1S cells | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG expressed in HEK293 cells after 5 mins by patch clamp assay | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
mitogen-activated protein kinase kinase kinase kinase 4/Mitogen-activated protein kinase kinase kinase kinase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6166] [GtoPdb: 2088] [UniProtKB: O95819] | ||||||||
ChEMBL | Inhibition of MAP4K4 (unknown origin) by cell based assay | B | 5.24 | pIC50 | 5700 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] | ||||||||
ChEMBL | Pim Kinase Binding Activity: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J. F., and He, Q. Y. (2005) Expert Rev. Proteomics, 2:649-657). A fluorescent-labeled Pim-specific peptide substrate, was custom synthesized by American Peptide Company (Sunnyvale, Calif.). A fluorescent-labeled Pim-specific peptide substrate, was custom synthesized by American Peptide Company (Sunnyvale, Calif.). Reaction Buffer contained 10 mM HEPES, pH 7.2, 10 mM MgCl2, 0.01% Tween 20, 2 mM DTT. Termination Buffer contained 190 mM HEPES, pH 7.2, 0.015% Brij-35, 0.2% Coating Reagent 3 (Caliper Life Sciences, Hopkinton, Mass.), 20 mM EDTA. Separation Buffer contained 100 mM HEPES, pH 7.2, 0.015% Brij-35, 0.1% Coating Reagent 3, 1:200 Coating Reagent 8 (Caliper Life Sciences, Hopkinton, Mass.), 10 mM EDTA and 5% DMSO. | B | 10.4 | pKi | 0.04 | nM | Ki | US-8614206-B2. Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use (2013) |
GtoPdb | - | - | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
ChEMBL | Inhibition of recombinant human PIM1 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10.52 | pKi | 0.03 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9] | ||||||||
GtoPdb | - | - | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
ChEMBL | Inhibition of recombinant human PIM2 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
Pim-3 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5407] [GtoPdb: 2160] [UniProtKB: Q86V86] | ||||||||
ChEMBL | Inhibition of recombinant human PIM3 using FAM-pimtide as substrate after 90 mins by Z-LYTE assay | B | 10.7 | pKi | 0.02 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
GtoPdb | - | - | 10.7 | pKi | 0.02 | nM | Ki | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL214] [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
ChEMBL | Antagonist activity at 5HT1A receptor (unknown origin) | B | 5.31 | pIC50 | 4900 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
ChEMBL | Agonist activity at 5HT1A receptor (unknown origin) | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (2019) 62: 2140-2153 [PMID:30715878] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]