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ChEMBL ligand: CHEMBL3297829 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
ChEMBL | Displacement of [125I]BE2254 from human alpha1a receptor expressed in HEK293 cells | B | 9.03 | pKi | 0.93 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
ChEMBL | Displacement of [125I]BE2254 from human alpha1b receptor expressed in HEK293 cells | B | 8.72 | pKi | 1.91 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
GtoPdb | - | - | 10.25 | pKi | - | - | - | Eur J Med Chem (2014) 83: 419-32 [PMID:24992070] |
ChEMBL | Displacement of [125I]BE2254 from human alpha1d receptor expressed in HEK293 cells | B | 10.25 | pKi | 0.06 | nM | Ki | Eur J Med Chem (2014) 83: 419-432 [PMID:24992070] |
α1D-adrenoceptor in Rat [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
GtoPdb | Antagonist potency determined in isolated rat thoracic aorta | - | 9.15 | pEC50 | - | - | - | Eur J Med Chem (2014) 83: 419-32 [PMID:24992070] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]