ChEMBL ligand: CHEMBL285819 (2-Chloroadenosine)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] Adenosine A1 receptor in Guinea pig [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] Adenosine A2a receptor in Guinea pig [ChEMBL: CHEMBL2605] [UniProtKB: P46616] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!
Adenosine deaminase in Bovine [ChEMBL: CHEMBL2966] [UniProtKB: P56658] There should be some charts here, you may need to enable JavaScript!
heat shock protein 90 beta family member 1/Endoplasmin in Human [ChEMBL: CHEMBL1075323] [GtoPdb: 2904] [UniProtKB: P14625] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 2A/Phosphodiesterase 2A in Human [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb	-	-	5.6	pKi	-	-	-	J Biol Chem (1994) 269: 32077-84 [PMID:7798201]; J Biol Chem (1999) 274: 3617-21 [PMID:9920910]
ChEMBL	Displacement of [3H]CPX from adenosine A1 receptor	B	7.74	pKi	18.4	nM	Ki	J. Nat. Prod. (1993) 56: 441-455 [PMID:8496700]
ChEMBL	Displacement of [3H]N6-phenylisopropyladenosine from recombinant human A1AR expressed in CHO cell membranes after 60 mins by liquid scintillation counting method	B	8.55	pKi	2.8	nM	Ki	J Med Chem (2016) 59: 11006-11026 [PMID:27933810]
ChEMBL	Binding affinity to human recombinant adenosine A1 receptor	B	8.86	pKi	1.39	nM	Ki	J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brain	B	7.6	pKi	25	nM	Ki	J. Med. Chem. (1982) 25: 197-207 [PMID:6279840]
ChEMBL	Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.	B	7.69	pKi	20.2	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes.	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1989) 32: 1667-1673 [PMID:2754691]
ChEMBL	Inhibition of [3H]PIA binding to rat cortical adenosine A1 receptor	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1992) 35: 4143-4149 [PMID:1433217]
ChEMBL	Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1988) 31: 271-273 [PMID:3336027]
ChEMBL	Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1992) 35: 407-422 [PMID:1738138]
ChEMBL	Binding affinity to adenosine A1 receptor in rat brain membranes by measuring displacement of specific [3H]PIA as radioligand.	B	8.03	pKi	9.3	nM	Ki	J. Med. Chem. (1995) 38: 1174-1188 [PMID:7707320]
ChEMBL	Displacement of [3H]CHA from adenosine A1 receptor of rat whole brain	B	8.06	pKi	8.74	nM	Ki	J. Med. Chem. (1985) 28: 1383-1384 [PMID:2995663]
GtoPdb	-	-	8.17	pKi	6.7	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Binding affinity towards adenosine A1 receptor in rat brain cortex	B	8.17	pKi	6.7	nM	Ki	J. Med. Chem. (2001) 44: 531-539 [PMID:11170643]
ChEMBL	Binding affinity towards adenosine A1 receptor in rat brain cortex	B	8.17	pKi	6.7	nM	Ki	J. Med. Chem. (2001) 44: 531-539 [PMID:11170643]
ChEMBL	Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor	B	8.17	pKi	6.7	nM	Ki	J. Med. Chem. (1991) 34: 3388-3390 [PMID:1766003]
ChEMBL	Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptor	B	7.43	pIC50	37	nM	IC50	J. Med. Chem. (1991) 34: 2570-2579 [PMID:1875349]
Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745]
ChEMBL	Prolongation of the stimulus-QRS interval by 50% of the maximum response at the adenosine A1 receptor in langendorff guinea pig heart preparation	F	6.72	pEC50	190.55	nM	EC50	J. Med. Chem. (1991) 34: 1334-1339 [PMID:2016707]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Binding affinity to human recombinant adenosine receptor A2a	B	6.74	pKi	180	nM	Ki	J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
GtoPdb	-	-	6.8	pKi	-	-	-	J Biol Chem (1995) 270: 13987-97 [PMID:7775460]; Biochem Pharmacol (1999) 57: 65-75 [PMID:9920286]
ChEMBL	Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.	B	6.92	pKi	120	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
ChEMBL	Binding affinity towards adenosine A2A receptor in rat brain striatum	B	7.12	pKi	76	nM	Ki	J. Med. Chem. (2001) 44: 531-539 [PMID:11170643]
ChEMBL	Binding affinity towards adenosine A2A receptor in rat brain striatum	B	7.12	pKi	76	nM	Ki	J. Med. Chem. (2001) 44: 531-539 [PMID:11170643]
ChEMBL	Inhibition of [3H]- NECA binding to adenosine receptor A2A	B	7.12	pKi	76	nM	Ki	J. Med. Chem. (1991) 34: 3388-3390 [PMID:1766003]
GtoPdb	-	-	7.12	pKi	76	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Tested for the binding affinity of A2a receptor by displacing the [3H]-CGS- 21680 in rat striatal membranes	B	7.2	pKi	63	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring displacement of specific [3H]-CGS- 21680 as radioligand	B	7.2	pKi	63	nM	Ki	J. Med. Chem. (1995) 38: 1174-1188 [PMID:7707320]
Adenosine A2a receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2605] [UniProtKB: P46616]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain	B	8.1	pKi	8	nM	Ki	J. Med. Chem. (1982) 25: 197-207 [PMID:6279840]
ChEMBL	Antagonism of cyclic [3H]AMP accumulation elicited by 15 uM 2-chloroadenosine in [3H]adenine-labeled guinea pig cerebral cortical slices at A2 receptor	F	5.1	pEC50	8000	nM	EC50	J. Med. Chem. (1985) 28: 487-492 [PMID:2984420]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
ChEMBL	Displacement of [125I]I-ABOPX from human recombinant adenosine A2B receptor expressed in HEK293 cells	B	4.59	pKi	25500	nM	Ki	J. Med. Chem. (2009) 52: 3994-4006 [PMID:19569717]
ChEMBL	Displacement of [3H]PSB-603 from human recombinant adenosine A2B receptor expressed in CHO cells	B	4.67	pKi	21400	nM	Ki	J. Med. Chem. (2009) 52: 3994-4006 [PMID:19569717]
GtoPdb	-	-	5	pKi	-	-	-	Mol Pharmacol (1999) 56: 705-13 [PMID:10496952]; Mol Pharmacol (2000) 58: 1349-56 [PMID:11093773]; Can J Physiol Pharmacol (1980) 58: 673-91 [PMID:6253037]
ChEMBL	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	F	3.72	pEC50	-3.72	-	logEC50	J. Med. Chem. (2008) 51: 2088-2099 [PMID:18321038]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Binding affinity at Mutant (H272E) human adenosine A3 receptor expressed in COS-7 cells	B	4.94	pKi	11600	nM	Ki	J. Med. Chem. (2001) 44: 4125-4136 [PMID:11708915]
ChEMBL	Binding affinity at wild-type Adenosine A3 receptor expressed in COS-7 cells	B	6.19	pKi	650	nM	Ki	J. Med. Chem. (2001) 44: 4125-4136 [PMID:11708915]
ChEMBL	Affinity for human Adenosine A3 receptor expressed in CHO cell	B	7.06	pKi	87	nM	Ki	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Binding affinity to human recombinant adenosine A3 receptor	B	7.72	pKi	19	nM	Ki	J. Med. Chem. (2014) 57: 3623-3650 [PMID:24164628]
ChEMBL	Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor	F	5.79	pEC50	1630	nM	EC50	J. Med. Chem. (2002) 45: 4471-4484 [PMID:12238926]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
ChEMBL	Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes	B	5.49	pKi	3200	nM	Ki	J. Med. Chem. (1998) 41: 1708-1715 [PMID:9572897]
GtoPdb	-	-	5.72	pKi	1890	nM	Ki	Mol Pharmacol (1994) 45: 1101-11 [PMID:8022403]
ChEMBL	Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO cells transfected with rat A3-cDNA	B	5.72	pKi	1890	nM	Ki	J. Med. Chem. (1994) 37: 3614-3621 [PMID:7932588]
ChEMBL	Binding affinity determined by displacement of specific binding of [125I]N-(4-amino-3-iodophenethyl)-adenosine in membranes of CHO cells stably transfected with the rat adenosine A3 receptor	B	5.72	pKi	1890	nM	Ki	J. Med. Chem. (1995) 38: 1174-1188 [PMID:7707320]
Adenosine deaminase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2966] [UniProtKB: P56658]
ChEMBL	Inhibition of calf placental adenosine deaminase by Lineweaver-Burk plot analysis	B	4.26	pKi	54500	nM	Ki	J. Med. Chem. (2011) 54: 107-121 [PMID:21138280]
heat shock protein 90 beta family member 1/Endoplasmin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075323] [GtoPdb: 2904] [UniProtKB: P14625]
ChEMBL	Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay	B	5.07	pKd	8600	nM	Kd	ACS Med Chem Lett (2021) 12: 373-379 [PMID:33738064]
ChEMBL	Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluorescence polarization assay	B	5.74	pKi	1800	nM	Ki	ACS Med Chem Lett (2021) 12: 373-379 [PMID:33738064]
phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408]
ChEMBL	Inhibition of recombinant human PDE2A catalytic domain (580 to 919 residues) expressed in Escherichia coli BL21 (Codonplus) using [3H]cGMP as substrate after 15 mins by liquid scintillation counting method	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem (2018) 26: 119-133 [PMID:29174506]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay	F	5	pIC50	10000	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay	F	5.1	pIC50	7943.28	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay	F	5.2	pIC50	6309.57	nM	IC50	Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL224] [GtoPdb: 6] [UniProtKB: P28223]
ChEMBL	Displacement of [3H]ketanserin from human 5-HT2A receptor expressed in HEK-T cell membranes incubated for 90 mins under dark condition by microbeta scintillation counting method	B	5	pKi	>10000	nM	Ki	J Med Chem (2016) 59: 11006-11026 [PMID:27933810]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]