vodobatinib [Ligand Id: 11191] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4130229 (K-0706, K0706, Sco-088, Vodobatinib) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| ABL proto-oncogene 1, non-receptor tyrosine kinase in Human [GtoPdb: 1923] [UniProtKB: P00519] | ||||||||
| GtoPdb | Inhibition of Abl1E255V expressed in in Ba/F3 cells. | - | 6.78 | pIC50 | 165 | nM | IC50 | Exp Hematol (2019) 77: 36-40.e2 [PMID:31493432] |
| GtoPdb | Inhibition of wild type Abl1 expressed in in Ba/F3 cells. | - | 8.15 | pIC50 | 7 | nM | IC50 | Exp Hematol (2019) 77: 36-40.e2 [PMID:31493432] |
| GtoPdb | Inhibition of Abl1F311L expressed in in Ba/F3 cells. | - | 8.22 | pIC50 | 6 | nM | IC50 | Exp Hematol (2019) 77: 36-40.e2 [PMID:31493432] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
