BMS-963272 [Ligand Id: 12738] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3912712 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acyl-CoA wax alcohol acyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375204] [UniProtKB: Q6E213] | ||||||||
| ChEMBL | Inhibition of human AWAT2 | B | 4.48 | pIC50 | >33000 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321630] [UniProtKB: Q10469] | ||||||||
| ChEMBL | Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins by scintillation proximity assay | B | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375203] [UniProtKB: Q921V5] | ||||||||
| ChEMBL | Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879456] [UniProtKB: Q09326] | ||||||||
| ChEMBL | Inhibition of rat recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375206] [UniProtKB: Q09327] | ||||||||
| ChEMBL | Inhibition of human MGAT3 | B | 6.09 | pIC50 | >820 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907] | ||||||||
| ChEMBL | Inhibition of human DGAT1 | B | 4.48 | pIC50 | >33000 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Stanniocalcin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879441] [UniProtKB: P52823] | ||||||||
| ChEMBL | Inhibition of human STC1 in cell based assay | B | 7.48 | pIC50 | 33 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| Stanniocalcin-1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879418] [UniProtKB: O55183] | ||||||||
| ChEMBL | Inhibition of mouse STC1 in cell based assay | B | 7.06 | pIC50 | 88 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| monoacylglycerol O-acyltransferase 2 in Human [GtoPdb: 2881] [UniProtKB: Q3SYC2] | ||||||||
| GtoPdb | - | - | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
| monoacylglycerol O-acyltransferase 2 in Mouse [GtoPdb: 2881] [UniProtKB: Q80W94] | ||||||||
| GtoPdb | - | - | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (2021) 64: 14773-14792 [PMID:34613725] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
