ChEMBL ligand: CHEMBL3912712
Acyl-CoA wax alcohol acyltransferase 2 in Human [ChEMBL: CHEMBL2375204] [UniProtKB: Q6E213] There should be some charts here, you may need to enable JavaScript!
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Human [ChEMBL: CHEMBL2321630] [UniProtKB: Q10469] Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Mouse [ChEMBL: CHEMBL2375203] [UniProtKB: Q921V5] Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Rat [ChEMBL: CHEMBL4879456] [UniProtKB: Q09326] There should be some charts here, you may need to enable JavaScript!
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase in Human [ChEMBL: CHEMBL2375206] [UniProtKB: Q09327] There should be some charts here, you may need to enable JavaScript!
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907] There should be some charts here, you may need to enable JavaScript!
monoacylglycerol O-acyltransferase 2 in Human [GtoPdb: 2881] [UniProtKB: Q3SYC2] monoacylglycerol O-acyltransferase 2 in Mouse [GtoPdb: 2881] [UniProtKB: Q80W94] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Acyl-CoA wax alcohol acyltransferase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375204] [UniProtKB: Q6E213]
ChEMBL	Inhibition of human AWAT2	B	4.48	pIC50	>33000	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2321630] [UniProtKB: Q10469]
ChEMBL	Inhibition of human MGAT2 in mouse STC-1 cell based assay	B	7.48	pIC50	33	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
ChEMBL	Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins by scintillation proximity assay	B	8.15	pIC50	7.1	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375203] [UniProtKB: Q921V5]
ChEMBL	Inhibition of mouse MGAT2 in mouse STC-1 cell based assay	B	7.06	pIC50	88	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
ChEMBL	Inhibition of mouse recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay	B	7.74	pIC50	18	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4879456] [UniProtKB: Q09326]
ChEMBL	Inhibition of rat recombinant MGAT2 expressed in Sf9 cell membrane using 2-oleoylglycerol and oleoyl-CoA as substrates incubated for 10 mins by LCMS assay	B	8	pIC50	10	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2375206] [UniProtKB: Q09327]
ChEMBL	Inhibition of human MGAT3	B	6.09	pIC50	>820	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
diacylglycerol O-acyltransferase 1/Diacylglycerol O-acyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6009] [GtoPdb: 2821] [UniProtKB: O75907]
ChEMBL	Inhibition of human DGAT1	B	4.48	pIC50	>33000	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
monoacylglycerol O-acyltransferase 2 in Human [GtoPdb: 2881] [UniProtKB: Q3SYC2]
GtoPdb	-	-	8.15	pIC50	7.1	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]
monoacylglycerol O-acyltransferase 2 in Mouse [GtoPdb: 2881] [UniProtKB: Q80W94]
GtoPdb	-	-	7.74	pIC50	18	nM	IC50	J Med Chem (2021) 64: 14773-14792 [PMID:34613725]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]