ChEMBL ligand: CHEMBL361497 (.alpha.-artesunic acid, Artesunate, Artesunate amivas, Artesunatum, Artesunic acid, Dihydroqinghaosu hemisuccinate, LJPC-0118, NSC-712571, Plasmotrin, Qinghaozhi, Saphnate, Zysunate)
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
Plasmodium malariae [ChEMBL: CHEMBL613257] There should be some charts here, you may need to enable JavaScript!
Plasmodium vivax [ChEMBL: CHEMBL613013] There should be some charts here, you may need to enable JavaScript!
Plasmodium yoelii [ChEMBL: CHEMBL612889] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH release assay	F	5.28	pIC50	<5202	nM	IC50	Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	5.28	pIC50	<5200	nM	IC50	J Nat Prod (2018) 81: 41-48 [PMID:29309141]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	5.52	pIC50	3000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	5.62	pIC50	2400	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Gametocytocidal antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 late gametocyte stage after 72 hrs by alamar blue assay	F	5.64	pIC50	2300	nM	IC50	J Nat Prod (2013) 76: 388-393 [PMID:23286240]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	5.68	pIC50	2100	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 96 hrs by [3H]hypoxanthine incorporation assay	F	5.7	pIC50	2000	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	5.77	pIC50	1700	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against multi-drug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I dye-based fluorescence assay in presence of ascorbic acid	F	6.15	pIC50	700	nM	IC50	Eur J Med Chem (2015) 95: 16-28 [PMID:25791675]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 late gametocytes transfected with luciferase gene incubated for 48 hrs by luciferase reporter gene assay	F	6.59	pIC50	259	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54 after 48 hrs by lactate dehydrogenase assay	F	6.71	pIC50	194	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation counting	F	6.71	pIC50	194	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 4 & 5)	F	6.97	pIC50	108	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 gametocytes (stage 2 & 3)	F	7.14	pIC50	72	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 early gametocytes transfected with luciferase gene incubated for 48 hrs by luciferase reporter gene assay	F	7.2	pIC50	63	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum Dd2 by lactate dehydrogenase assay	F	7.34	pIC50	46	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL	Gametocytocidal activity against transgenic Plasmodium falciparum NF54-pfs16-GFP late stage gametocytes after 72 hrs by mitotracker red CM-H2XRos dye based confocal imaging assay	F	7.36	pIC50	44	nM	IC50	J Med Chem (2014) 57: 7971-7976 [PMID:25195945]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2	F	7.51	pIC50	31.2	nM	IC50	Eur J Med Chem (2013) 66: 314-323 [PMID:23811093]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by lactate dehydrogenase assay	F	7.51	pIC50	31.2	nM	IC50	J Med Chem (2014) 57: 435-448 [PMID:24354322]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.56	pIC50	27.7	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.58	pIC50	26.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.58	pIC50	26.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.58	pIC50	26.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.58	pIC50	26.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.61	pIC50	24.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay	F	7.62	pIC50	24.2	nM	IC50	Bioorg Med Chem (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.63	pIC50	23.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.63	pIC50	23.6	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	7.64	pIC50	22.8	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone M4 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.67	pIC50	21.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	7.7	pIC50	20	nM	IC50	Medchemcomm (2013) 4: 724-730
ChEMBL	Gametocytocidal activity against synchronous stage 1 to 3 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by luciferase reporter gene assay	F	7.72	pIC50	19	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	OSM: Inhibition of Plasmodium falciparum 3D7 growth using a SYBR green I fluorescence based assay. GSK Tres Cantos.	F	7.72	pIC50	19	nM	IC50	Open Source Malaria Deposition 1. http://malaria.ourexperiment.org
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	7.73	pIC50	18.43	nM	IC50	Eur J Med Chem (2021) 213: 113193-113193 [PMID:33508479]
ChEMBL	Antimalarial activity against chloroquine-resistant asexual intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as inhibition of parasite growth by lactate dehydrogenase assay	F	7.76	pIC50	17.4	nM	IC50	Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of [3H]hypoxanthine incorporation	F	7.77	pIC50	17	nM	IC50	Med Chem Res (2011) 20: 321-332
ChEMBL	Antimalarial activity against Plasmodium falciparum D10 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.77	pIC50	16.8	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.8	pIC50	16	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 by LDH release assay	F	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2018) 148: 39-53 [PMID:29454189]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.83	pIC50	14.9	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.83	pIC50	14.9	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antiplasmodial activity against chloroquine-resistant synchronized trophozoite stage of Plasmodium falciparum Dd2 after 48 hrs by NBT dye based LDH assay	F	7.84	pIC50	14.3	nM	IC50	J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.85	pIC50	14.2	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.87	pIC50	13.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation	F	7.87	pIC50	13.5	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum Dd2 infected in erythrocytes assessed as reduction in parasite growth incubated for 48 hrs under hypoxic condition by Hoechst 33342 staining based flow cytometry	F	7.88	pIC50	13.3	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.88	pIC50	13.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	7.89	pIC50	13	nM	IC50	ACS Med Chem Lett (2019) 10: 714-719 [PMID:31097988]
ChEMBL	Antimalarial activity against chloroquine-sensitive asexual intraerythrocytic stage of Plasmodium falciparum NF54 assessed as inhibition of parasite growth by lactate dehydrogenase assay	F	7.9	pIC50	12.6	nM	IC50	Eur J Med Chem (2015) 101: 52-62 [PMID:26114811]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.91	pIC50	12.4	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation	F	7.92	pIC50	12.1	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3842-3852 [PMID:20566762]
ChEMBL	Antigametocytocidal activity against Plasmodium falciparum NF54-pfs16-GPF late (4 to 6) gametocyte assessed as viability after 72 hrs by MitoTracker Red CM-H2XRos/micro-plate confocal imaging system	F	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay	F	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2015) 92: 91-102 [PMID:25544689]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 incubated for 48 hrs by parasite lactate dehydrogenase assay	F	8	pIC50	10	nM	IC50	ACS Med Chem Lett (2019) 10: 714-719 [PMID:31097988]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SKF58	F	8	pIC50	10	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8	pIC50	10	nM	IC50	Medchemcomm (2014) 5: 842-852 [PMID:25089179]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual blood stage of Plasmodium falciparum NF54 by LDH assay	F	8.01	pIC50	9.8	nM	IC50	Eur J Med Chem (2019) 180: 121-133 [PMID:31301563]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 by LDH assay	F	8.03	pIC50	9.3	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as parasite growth inhibition after 72 hrs by SYBR Green I assay	F	8.05	pIC50	9	nM	IC50	Bioorg Med Chem (2015) 23: 5452-5458 [PMID:26260339]
ChEMBL	Antimalarial activity against CQ-sensitive Plasmodium falciparum 3D7 infected in erythrocytes by SYBR Green dye based fluorescence assay	F	8.05	pIC50	9	nM	IC50	Eur J Med Chem (2021) 209: 112941-112941 [PMID:33158577]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.05	pIC50	8.97	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antiplasmodial activity against asexual erythrocytic stage of chloroquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 48 hrs by lactate dehydrogenase assay	F	8.09	pIC50	8.1	nM	IC50	Eur J Med Chem (2014) 76: 470-481 [PMID:24602791]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocyte stage form Plasmodium falciparum NF54 measured after 48 hrs by pLDH assay	F	8.1	pIC50	8	nM	IC50	Eur J Med Chem (2016) 122: 635-646 [PMID:27448920]
ChEMBL	Antimicrobial activity against Plasmodium falciparum at ring stage	F	8.1	pIC50	8	nM	IC50	Antimicrob Agents Chemother (2008) 52: 2435-2441 [PMID:18443130]
ChEMBL	Gametocytocidal activity against synchronous stage 4 to 5 of transgenic Plasmodium falciparum NF54 gametocyte harboring pfs16 promoter assessed as parasite viability after 72 hrs by MitoTracker Red CMXRos-based assay	F	8.1	pIC50	8	nM	IC50	J Med Chem (2013) 56: 6200-6215 [PMID:23837878]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 late stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based imaging method	F	8.1	pIC50	8	nM	IC50	Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL	Antimalarial activity against chloroquine-sensitive asexual Plasmodium falciparum NF54 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.1	pIC50	7.88	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antiplasmodial activity against chloroquine-resistant synchronized trophozoite stage of Plasmodium falciparum 7G8 after 48 hrs by NBT dye based LDH assay	F	8.11	pIC50	7.7	nM	IC50	J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocyte stage form Plasmodium falciparum Dd2 measured after 48 hrs by pLDH assay	F	8.12	pIC50	7.5	nM	IC50	Eur J Med Chem (2016) 122: 635-646 [PMID:27448920]
ChEMBL	Antiplasmodium activity against chloroquine-sensitive Plasmodium falciparum NF54 asexual blood stage forms infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	8.15	pIC50	7	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Antimalarial activity against multidrug resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I fluorescence based assay	F	8.17	pIC50	6.77	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3006-3009 [PMID:27210430]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum D10 assessed as parasite growth inhibition by lactate dehydrogenase assay	F	8.2	pIC50	6.3	nM	IC50	J Med Chem (2014) 57: 435-448 [PMID:24354322]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 asexual gametocytes	F	8.22	pIC50	6	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antimalarial activity against Plasmodium falciparum Dd2 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.22	pIC50	6	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.22	pIC50	6	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method	F	8.24	pIC50	5.71	nM	IC50	Eur J Med Chem (2015) 90: 33-44 [PMID:25461309]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive synchronized trophozoite stage of Plasmodium falciparum NF54 after 48 hrs by NBT dye based LDH assay	F	8.25	pIC50	5.6	nM	IC50	J Med Chem (2017) 60: 10245-10256 [PMID:29185748]
ChEMBL	Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting	F	8.28	pIC50	5.3	nM	IC50	Eur J Med Chem (2012) 52: 82-97 [PMID:22459876]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum NF54	F	8.28	pIC50	<5.2	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual erythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition by parasite lactate dehydrogenase assay	F	8.28	pIC50	<5.2	nM	IC50	Bioorg Med Chem (2015) 23: 4163-4171 [PMID:26174655]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 asexual erythrocyte stages by parasite lactate dehydrogenase assay	F	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem Lett (2014) 24: 5207-5211 [PMID:25316314]
ChEMBL	Antiplasmodial activity against asexual erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 assessed as parasite growth inhibition after 48 hrs by lactate dehydrogenase assay	F	8.28	pIC50	<5.2	nM	IC50	Eur J Med Chem (2014) 76: 470-481 [PMID:24602791]
ChEMBL	Antimalarial activity against ring-stage chloroquine-susceptible Plasmodium falciparum 3D7 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis	F	8.29	pIC50	5.1	nM	IC50	Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual erythrocytic stage of Plasmodium falciparum NF54 assessed as [3H]-hypoxanthine incorporation by lactate dehydrogenase assay	F	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2015) 92: 91-102 [PMID:25544689]
ChEMBL	Antiplasmodial activity chloroquine-sensitive Plasmodium falciparum NF54 by lactate dehydrogenase assay	F	8.3	pIC50	5	nM	IC50	Bioorg Med Chem Lett (2014) 24: 1214-1217 [PMID:24468411]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis	F	8.31	pIC50	4.9	nM	IC50	Medchemcomm (2011) 2: 661-665
ChEMBL	Antimalarial activity against ring-stage multidrug-resistant Plasmodium falciparum Dd2 preincubated for 6 hrs followed by compound wash and measured after 66 hrs by Giemsa-staining based light microscopic analysis	F	8.34	pIC50	4.6	nM	IC50	Eur J Med Chem (2019) 163: 404-412 [PMID:30530192]
ChEMBL	Antiplasmodial activity against blood stage of chloroquine-sensitive Plasmodium falciparum NF54 by parasite lactate dehydrogenase assay	F	8.36	pIC50	4.4	nM	IC50	Eur J Med Chem (2015) 101: 266-273 [PMID:26142491]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7	F	8.38	pIC50	4.2	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 within 48 hrs	F	8.38	pIC50	4.2	nM	IC50	Antimicrob Agents Chemother (2007) 51: 667-672 [PMID:17145800]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 infected in mouse at 30 mg/kg, po	F	8.38	pIC50	4.2	nM	IC50	J Med Chem (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL	Antiplasmodial activity against chloroquine/mefloquine-resistant Plasmodium falciparum SRIV35	F	8.39	pIC50	4.1	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against Plasmodium falciparum Cam3.1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps, pf-kelch13 mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.4	pIC50	4	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum NF54	F	8.4	pIC50	4	nM	IC50	J Med Chem (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting	F	8.4	pIC50	4	nM	IC50	Medchemcomm (2017) 8: 1152-1157 [PMID:30108825]
ChEMBL	Antimalarial activity against drug-sensitive Plasmodium falciparum NF54	F	8.4	pIC50	4	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite proliferation after 96 hrs by SYBR Green I-based fluorescence method	F	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2015) 90: 33-44 [PMID:25461309]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum NF54	F	8.4	pIC50	4	nM	IC50	J Med Chem (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive asexual blood stage of Plasmodium falciparum NF54 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.4	pIC50	4	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 by [3H]-hypoxanthine incorporation assay	F	8.4	pIC50	4	nM	IC50	J Med Chem (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL	Antiplasmodial activity against multidrug-sensitive Plasmodium falciparum NF54 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.4	pIC50	4	nM	IC50	J Med Chem (2016) 59: 9890-9905 [PMID:27748596]
ChEMBL	Antiplasmodial activity against multidrug resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.4	pIC50	4	nM	IC50	J Med Chem (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL	Antiplasmodial activity against drug-sensitive blood stage Plasmodium falciparum 3D7 by SYBR green 1 staining based fluorescence assay	F	8.4	pIC50	4	nM	IC50	J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.4	pIC50	4	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 infected in human RBC after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.4	pIC50	4	nM	IC50	Medchemcomm (2015) 6: 2023-2028
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian infected in human blood after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.42	pIC50	3.8	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2203-2207 [PMID:31255483]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMT10500 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.42	pIC50	3.8	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antimalarial activity against late stage gametocyte stage of Plasmodium falciparum NF54 after 72 hrs	F	8.42	pIC50	3.8	nM	IC50	Eur J Med Chem (2014) 82: 204-213 [PMID:24904967]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.46	pIC50	3.5	nM	IC50	Eur J Med Chem (2015) 94: 56-62 [PMID:25747499]
ChEMBL	Antimalarial activity against late (4 to 5) gametocytic stage of Plasmodium falciparum after 72 hrs by image-based HTS assay	F	8.46	pIC50	3.43	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.47	pIC50	3.4	nM	IC50	J Med Chem (2013) 56: 2547-2555 [PMID:23489135]
ChEMBL	Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum 3D7 assessed as inhibition of parasite growth incubated for 3 days by HRP2-ELISA assay	F	8.48	pIC50	3.3	nM	IC50	Eur J Med Chem (2022) 244: 114774-114774 [PMID:36306538]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay	F	8.48	pIC50	3.3	nM	IC50	Antimicrob Agents Chemother (2010) 54: 3597-3604 [PMID:20547797]
ChEMBL	Antiplasmodial activity against drug-resistant Plasmodium falciparum Dd2 ring stage forms assessed as inhibition of parasite growth after 72 hrs by DAPI staining-based confocal microscopic analysis	F	8.48	pIC50	3.3	nM	IC50	J Nat Prod (2019) 82: 1019-1023 [PMID:30865443]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum K1 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	8.49	pIC50	3.26	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against Plasmodium falciparum NF54 incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.49	pIC50	3.2	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1	F	8.49	pIC50	3.2	nM	IC50	Antimicrob Agents Chemother (2008) 52: 1291-1296 [PMID:18268087]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 early stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method	F	8.52	pIC50	3	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antimalarial activity against Plasmodium falciparum 7G8 harbouring Pf-crt, Pf-mdrl,Pf-dhfr, Pf-dhps mutated loci assessed as inhibition of parasite growth incubated for 48 hrs by [3H]hypoxanthine incorporation assay based liquid scintillation counting method	F	8.52	pIC50	3	nM	IC50	J Med Chem (2021) 64: 12582-12602 [PMID:34437804]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum K1	F	8.52	pIC50	3	nM	IC50	J Med Chem (2011) 54: 7713-7719 [PMID:21966980]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 ring stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based confocal microscopic method	F	8.52	pIC50	3	nM	IC50	J Med Chem (2017) 60: 6036-6044 [PMID:28653845]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum IMTVo1 infected in erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2009) 52: 7954-7957 [PMID:19908867]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 infected in erythrocytes assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by liquid scintillation counting method	F	8.52	pIC50	3	nM	IC50	J Med Chem (2016) 59: 9890-9905 [PMID:27748596]
ChEMBL	Antiplasmodial activity against drug sensitive Plasmodium falciparum NF54 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2015) 58: 8713-8722 [PMID:26502160]
ChEMBL	Antiplasmodial activity against chloroquine/cycloguanil/pyrimethamine-resistant blood stage Plasmodium falciparum K1 by SYBR green 1 staining based fluorescence assay	F	8.52	pIC50	3	nM	IC50	J Nat Prod (2018) 81: 188-202 [PMID:29297684]
ChEMBL	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]-hypoxanthine incorporation assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2015) 58: 7572-7579 [PMID:26322748]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	8.52	pIC50	3	nM	IC50	J Med Chem (2018) 61: 4213-4227 [PMID:29665687]
ChEMBL	Antiplasmodial activity against chloroquine-resistant asexual blood stage of Plasmodium falciparum K1 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting method	F	8.52	pIC50	3	nM	IC50	J Med Chem (2019) 62: 1022-1035 [PMID:30562027]
ChEMBL	Antigametocytocidal activity against Plasmodium falciparum NF54-pfs16-GPF early (1 to 3) gametocyte assessed as viability after 72 hrs by MitoTracker Red CM-H2XRos/micro-plate confocal imaging system	F	8.52	pIC50	3	nM	IC50	Bioorg Med Chem Lett (2015) 25: 327-332 [PMID:25488841]
ChEMBL	Gametocytocidal activity against transgenic GFP-fused Plasmodium falciparum NF54 early stage gametocytes after 72 hrs by Mitotracker Red CMH2XRos staining based imaging method	F	8.52	pIC50	3	nM	IC50	Eur J Med Chem (2018) 158: 801-813 [PMID:30245402]
ChEMBL	Antimalarial activity against multidrug-resistant Plasmodium falciparum K1	F	8.52	pIC50	3	nM	IC50	J Med Chem (2014) 57: 2789-2798 [PMID:24568587]
ChEMBL	Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes preincubated for 48 hrs followed by [3H]-hypoxanthine addition and measured after 24 hrs by liquid scintillation counting	F	8.52	pIC50	3	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum K1 after 48 hrs by lactate dehydrogenase assay	F	8.52	pIC50	3	nM	IC50	J Med Chem (2018) 61: 9371-9385 [PMID:30256636]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum NF54 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	8.52	pIC50	3	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum FC27 infected in human RBC assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	8.54	pIC50	2.9	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antiplasmodium activity against multidrug resistant Plasmodium falciparum K1 asexual blood stage forms infected in human erythrocytes assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	8.54	pIC50	2.9	nM	IC50	Medchemcomm (2019) 10: 450-455 [PMID:31015908]
ChEMBL	Antiplasmodial activity chloroquine-resistant Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 24 hrs by scintillation counting	F	8.55	pIC50	2.8	nM	IC50	Eur J Med Chem (2012) 52: 82-97 [PMID:22459876]
ChEMBL	Antimalarial activity against Plasmodium falciparum TM90C2B incubated for 48 hrs by [3H]-hypoxanthine incorporation assay	F	8.57	pIC50	2.7	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antiplasmodial activity against chloroquine sensitive Plasmodium falciparum NF54 assessed as reduction in [3H]-hypoxanthine incorporation incubated for 48 hrs by liquid scintillation counting method	F	8.59	pIC50	2.6	nM	IC50	Eur J Med Chem (2017) 140: 595-603 [PMID:28988153]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine incorporation assay	F	8.59	pIC50	2.6	nM	IC50	Bioorg Med Chem Lett (2017) 27: 658-661 [PMID:28012840]
ChEMBL	Antimalarial activity against Plasmodium falciparum FCR-3/Gambia	F	8.6	pIC50	2.5	nM	IC50	Medchemcomm (2014) 5: 842-852 [PMID:25089179]
ChEMBL	Antimicrobial activity against Plasmodium falciparum NF54	F	8.6	pIC50	2.5	nM	IC50	ACS Med Chem Lett (2011) 2: 316-319 [PMID:21666827]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth after 48 hrs by [3H]hypoxanthine reuptake assay	F	8.61	pIC50	2.46	nM	IC50	Eur J Med Chem (2009) 44: 5071-5079 [PMID:19811859]
ChEMBL	Antimalarial activity against drug sensitive Plasmodium falciparum NF54	F	8.62	pIC50	2.4	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum K1	F	8.62	pIC50	2.4	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum W2 assessed as reduction in parasite growth incubated for 96 hrs by SYBR Green I dye-based fluorescence assay	F	8.62	pIC50	2.4	nM	IC50	ACS Med Chem Lett (2020) 11: 49-55 [PMID:31938463]
ChEMBL	Antimalarial activity against drug resistant Plasmodium falciparum W2	F	8.62	pIC50	2.4	nM	IC50	Eur J Med Chem (2021) 210: 113084-113084 [PMID:33333397]
ChEMBL	Antiplasmodial activity against chloroquine resistant Plasmodium falciparum by HRP2 ELISA analysis	F	8.63	pIC50	2.34	nM	IC50	Eur J Med Chem (2021) 219: 113408-113408 [PMID:33989911]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1	F	8.64	pIC50	2.3	nM	IC50	Antimicrob Agents Chemother (2007) 51: 1463-1472 [PMID:17242150]
ChEMBL	Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum by [3H]hypoxanthine incorporation	F	8.64	pIC50	2.3	nM	IC50	J Med Chem (2008) 51: 1260-1277 [PMID:18260613]
ChEMBL	Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry	F	8.64	pIC50	2.3	nM	IC50	J Med Chem (2019) 62: 2485-2498 [PMID:30715882]
ChEMBL	Antimalarial activity against asexual stage of Plasmodium falciparum 3D7 after 72 hrs by image-based HTS assay	F	8.66	pIC50	2.2	nM	IC50	J Med Chem (2013) 56: 7727-7740 [PMID:23927763]