sulfadiazine   Click here for help

GtoPdb Ligand ID: 12635

Approved drug
sulfadiazine is an approved drug (FDA (1941), UK (2008))
Compound class: Synthetic organic
Comment: Sulfadiazine is a sulfonamide with broad-spectrum antimicrobial activity [4]. It is used in the treatment of toxoplasmosis, an infection with the protozoan parasite Toxoplasma gondi that can cause serious complications during pregnancy and in patients with weakened immune systems. Dermatological formulations containing silver sulfadiazine (PubChem CID 441244) are used to prevent and treat wound infections.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 105.29
Molecular weight 250.28
XLogP -1.47
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
InChI Key SEEPANYCNGTZFQ-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1941), UK (2008))
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
IUPAC Name Click here for help
4-amino-N-pyrimidin-2-ylbenzenesulfonamide
International Nonproprietary Names Click here for help
INN number INN
421 sulfadiazine
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Sulfadiazine, silver sulfadiazine (salt of sulphadiazine)
Other databases
CAS Registry No. 68-35-9 (source: Scifinder)
ChEBI CHEBI:9328
ChEMBL Ligand CHEMBL439
DrugBank Ligand DB00359
DrugCentral Ligand 2500
GtoPdb PubChem SID 479821425
PubChem CID 5215
Search Google for chemical match using the InChIKey SEEPANYCNGTZFQ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SEEPANYCNGTZFQ
Search PubMed clinical trials sulfadiazine
Search PubMed titles sulfadiazine
Search PubMed titles/abstracts sulfadiazine
UniChem Compound Search for chemical match using the InChIKey SEEPANYCNGTZFQ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey SEEPANYCNGTZFQ-UHFFFAOYSA-N
Wikipedia Sulfadiazine