ChEMBL ligand: CHEMBL574602
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]CCPA from human recombinant adenosine A1 receptor expressed in CHO cells	B	4.48	pKi	32800	nM	Ki	J Med Chem (2009) 52: 7897-7900 [PMID:19839592]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A2A receptor expressed in CHO cells	B	4.38	pKi	41700	nM	Ki	J Med Chem (2009) 52: 7897-7900 [PMID:19839592]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Displacement of [3H]NECA from human recombinant adenosine A3 receptor expressed in CHO cells	B	9.36	pKi	0.44	nM	Ki	J Med Chem (2009) 52: 7897-7900 [PMID:19839592]
ChEMBL	Binding affinity to human A3AR assessed as inhibitor constant	B	9.36	pKi	0.44	nM	Ki	ACS Med Chem Lett (2020) 11: 1935-1941 [PMID:33062176]
GtoPdb	-	-	9.36	pKi	0.44	nM	Ki	J Med Chem (2009) 52: 7897-900 [PMID:19839592]
ChEMBL	Binding affinity to human adenosine A3 receptor	B	9.36	pKi	0.44	nM	Ki	Bioorg Med Chem (2010) 18: 7923-7930 [PMID:20943397]
ChEMBL	Agonist activity at human recombinant adenosine A3 receptor expressed in CHO cells assessed as nonradiaoactive DELFIA Eu-GTP binding treated for 15 mins before addition of Eu-GTP measured after 45 mins by time-resolved fluorometric method	B	6.82	pEC50	151	nM	EC50	J Med Chem (2009) 52: 7897-7900 [PMID:19839592]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]