TAK-715 [Ligand Id: 9328] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL363648 (Tak-715, TAK 715, TAK-715) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mitogen-activated protein kinase 8/c-Jun N-terminal kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2276] [GtoPdb: 1496] [UniProtKB: P45983] | ||||||||
| ChEMBL | Inhibitory concentration against c-Jun N-terminal kinase 1 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| inhibitor of nuclear factor kappa B kinase subunit beta/Inhibitor of nuclear factor kappa B kinase beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1991] [GtoPdb: 2039] [UniProtKB: O14920] | ||||||||
| ChEMBL | Inhibitory concentration against I-kappa-B kinase beta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase 3 | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of recombinant human FLAG-tagged p38alpha expressed in baculovirus expression system using GFP-ATF2 (19 to 96 residues) as substrate preincubated for 5 mins followed by ATP addition measured after 20 mins by TR-FRET assay | B | 6.62 | pIC50 | 240 | nM | IC50 | Bioorg Med Chem (2018) 26: 647-660 [PMID:29291937] |
| ChEMBL | Displacement of SKF86002 from recombinant human p38alpha by fluorescence-based assay | B | 7.15 | pIC50 | 71 | nM | IC50 | Medchemcomm (2013) 4: 371-377 |
| ChEMBL | In vitro inhibitory activity against mitogen-activated protein kinase p38 alpha | B | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| ChEMBL | Inhibition of p38 alpha (unknown origin) | B | 8.15 | pIC50 | 7.1 | nM | IC50 | Eur J Med Chem (2021) 215: 113277-113277 [PMID:33601311] |
| GtoPdb | - | - | 8.15 | pIC50 | 7.1 | nM | IC50 | J Med Chem (2005) 48: 5966-79 [PMID:16162000] |
| mitogen-activated protein kinase 11/MAP kinase p38 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3961] [GtoPdb: 1500] [UniProtKB: Q15759] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-beta | B | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| GtoPdb | - | - | 6.7 | pIC50 | 200 | nM | IC50 | J Med Chem (2005) 48: 5966-79 [PMID:16162000] |
| mitogen-activated protein kinase 13/MAP kinase p38 delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2939] [GtoPdb: 1502] [UniProtKB: O15264] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-delta | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase 12/MAP kinase p38 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4674] [GtoPdb: 1501] [UniProtKB: P53778] | ||||||||
| ChEMBL | Inhibitory concentration against mitogen-activated protein kinase p38-gamma | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| mitogen-activated protein kinase kinase kinase 1/Mitogen-activated protein kinase kinase kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3956] [GtoPdb: 2069] [UniProtKB: Q13233] | ||||||||
| ChEMBL | Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 1 (MEKK1) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
| microtubule affinity regulating kinase 3/Serine/threonine-protein kinase c-TAK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5600] [GtoPdb: 2099] [UniProtKB: P27448] | ||||||||
| ChEMBL | Inhibitory concentration against Mitogen-activated protein kinase kinase kinase 7 (TAK1) | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2005) 48: 5966-5979 [PMID:16162000] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
